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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 2006 Volume 29 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2006 Volume 29 Issue 2

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Article

Growth inhibition and apoptosis induction in ovarian cancer cells

  • Authors:
    • Rania Touma
    • Sabine Kartarius
    • Antonina Harlozinska
    • Claudia Götz
    • Mathias Montenarh

  • View Affiliations / Copyright

    Affiliations: Universität des Saarlandes, Medizinische Biochemie und Molekularbiologie, D-66421 Homburg, Germany
  • Pages: 481-488
    |
    Published online on: August 1, 2006
       https://doi.org/10.3892/ijo.29.2.481
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Abstract

Standard therapy for the treatment of ovarian cancer is radical surgery followed by radiation and/or chemotherapy using cisplatin and paclitaxel. Unfortunately, some patients relapse after this first line chemotherapy and some patients become platinum-refractory. Therefore, we analyzed two different ovarian carcinoma cell lines for their sensitivity for γ-irradiation and treatment with cisplatin, irinotecan, paclitaxel and gemcitabine. We found that both cell lines were rather resistant against γ-irradiation and treatment with cisplatin and irinotecan whereas paclitaxel and gemcitabine resulted in a considerable reduction of the viability of the cancer cells. Both paclitaxel and gemcitabine treatment resulted in the induction of apoptosis. This sensitivity profile might be due to a particular subset of p53, which reacted with monoclonal antibodies DO-1 and PAb1801 but not with PAb1620 and PAb421. Gemcitabine and paclitaxel are highly efficient in the induction of apoptosis in ovarian cancer cells, which express a particular subset of the growth suppressor protein p53. Thus, a sensitivity profile for each ovarian carcinoma seems to be highly recommended before starting treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Touma R, Kartarius S, Harlozinska A, Götz C and Montenarh M: Growth inhibition and apoptosis induction in ovarian cancer cells. Int J Oncol 29: 481-488, 2006.
APA
Touma, R., Kartarius, S., Harlozinska, A., Götz, C., & Montenarh, M. (2006). Growth inhibition and apoptosis induction in ovarian cancer cells. International Journal of Oncology, 29, 481-488. https://doi.org/10.3892/ijo.29.2.481
MLA
Touma, R., Kartarius, S., Harlozinska, A., Götz, C., Montenarh, M."Growth inhibition and apoptosis induction in ovarian cancer cells". International Journal of Oncology 29.2 (2006): 481-488.
Chicago
Touma, R., Kartarius, S., Harlozinska, A., Götz, C., Montenarh, M."Growth inhibition and apoptosis induction in ovarian cancer cells". International Journal of Oncology 29, no. 2 (2006): 481-488. https://doi.org/10.3892/ijo.29.2.481
Copy and paste a formatted citation
x
Spandidos Publications style
Touma R, Kartarius S, Harlozinska A, Götz C and Montenarh M: Growth inhibition and apoptosis induction in ovarian cancer cells. Int J Oncol 29: 481-488, 2006.
APA
Touma, R., Kartarius, S., Harlozinska, A., Götz, C., & Montenarh, M. (2006). Growth inhibition and apoptosis induction in ovarian cancer cells. International Journal of Oncology, 29, 481-488. https://doi.org/10.3892/ijo.29.2.481
MLA
Touma, R., Kartarius, S., Harlozinska, A., Götz, C., Montenarh, M."Growth inhibition and apoptosis induction in ovarian cancer cells". International Journal of Oncology 29.2 (2006): 481-488.
Chicago
Touma, R., Kartarius, S., Harlozinska, A., Götz, C., Montenarh, M."Growth inhibition and apoptosis induction in ovarian cancer cells". International Journal of Oncology 29, no. 2 (2006): 481-488. https://doi.org/10.3892/ijo.29.2.481
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