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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2006 Volume 29 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2006 Volume 29 Issue 3

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Article

Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer

  • Authors:
    • Takuma Fujii
    • Miyuki Saito
    • Eri Iwasaki
    • Takahiro Ochiya
    • Yoshifumi Takei
    • Shigenori Hayashi
    • Akiko Ono
    • Nobumaru Hirao
    • Masaru Nakamura
    • Kaneyuki Kubushiro
    • Katsumi Tsukazaki
    • Daisuke Aoki

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan. fujiit@sc.itc.keio.ac.jp
  • Pages: 541-548
    |
    Published online on: September 1, 2006
       https://doi.org/10.3892/ijo.29.3.541
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Abstract

Human papillomavirus (HPV) 18 is related not only to squamous cell carcinoma of the cervix, but also to adenocarcinoma and small cell carcinoma of the cervix, in which prognosis is known to be poor. Small interfering RNA (siRNA) that targets HPV18 E6 and E7 was tested in HPV18-positive cell lines to investigate its effect and investigate its mechanism of action. Nude mice were also tested in a combination of siRNA and atelocollagen to determine whether it might be useful as a new molecule-targeting therapy for cervical cancer. siRNAs targeting HPV18 E6 and E7 were transfected into cervical cancer cells in vitro and they were investigated for cell growth inhibition, expression of E6 and E7 mRNA, expression of retinoblastoma protein, and senescence-associated β-galactosidase staining. Sequence-specific siRNA inhibited cell growth. Decreased expression of E6 and E7 mRNA followed with E7 protein was observed in the transfected cells, but the expression of retinoblastoma protein and the β-galactosidase staining increased, suggesting cell growth inhibitory effect through senescence. Treatment of xenografts established from SKG-II cells with siRNA specific for E6 and E7 obviously suppressed tumor growth in vivo. These results indicate that atelocollagen-mediated delivery of siRNA HPV18 E6 and E7 can be used as a novel therapeutic approach for cervical cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Fujii T, Saito M, Iwasaki E, Ochiya T, Takei Y, Hayashi S, Ono A, Hirao N, Nakamura M, Kubushiro K, Kubushiro K, et al: Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer. Int J Oncol 29: 541-548, 2006.
APA
Fujii, T., Saito, M., Iwasaki, E., Ochiya, T., Takei, Y., Hayashi, S. ... Aoki, D. (2006). Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer. International Journal of Oncology, 29, 541-548. https://doi.org/10.3892/ijo.29.3.541
MLA
Fujii, T., Saito, M., Iwasaki, E., Ochiya, T., Takei, Y., Hayashi, S., Ono, A., Hirao, N., Nakamura, M., Kubushiro, K., Tsukazaki, K., Aoki, D."Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer". International Journal of Oncology 29.3 (2006): 541-548.
Chicago
Fujii, T., Saito, M., Iwasaki, E., Ochiya, T., Takei, Y., Hayashi, S., Ono, A., Hirao, N., Nakamura, M., Kubushiro, K., Tsukazaki, K., Aoki, D."Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer". International Journal of Oncology 29, no. 3 (2006): 541-548. https://doi.org/10.3892/ijo.29.3.541
Copy and paste a formatted citation
x
Spandidos Publications style
Fujii T, Saito M, Iwasaki E, Ochiya T, Takei Y, Hayashi S, Ono A, Hirao N, Nakamura M, Kubushiro K, Kubushiro K, et al: Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer. Int J Oncol 29: 541-548, 2006.
APA
Fujii, T., Saito, M., Iwasaki, E., Ochiya, T., Takei, Y., Hayashi, S. ... Aoki, D. (2006). Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer. International Journal of Oncology, 29, 541-548. https://doi.org/10.3892/ijo.29.3.541
MLA
Fujii, T., Saito, M., Iwasaki, E., Ochiya, T., Takei, Y., Hayashi, S., Ono, A., Hirao, N., Nakamura, M., Kubushiro, K., Tsukazaki, K., Aoki, D."Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer". International Journal of Oncology 29.3 (2006): 541-548.
Chicago
Fujii, T., Saito, M., Iwasaki, E., Ochiya, T., Takei, Y., Hayashi, S., Ono, A., Hirao, N., Nakamura, M., Kubushiro, K., Tsukazaki, K., Aoki, D."Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer". International Journal of Oncology 29, no. 3 (2006): 541-548. https://doi.org/10.3892/ijo.29.3.541
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