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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2006 Volume 29 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2006 Volume 29 Issue 6

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Article

RNF2 interacts with the linker region of the human P-glycoprotein

  • Authors:
    • Prema S. Rao
    • Kavita B. Mallya
    • Kalkunte S. Srivenugopal
    • K. C. Balaji
    • U. Subrahmanyeswara Rao

  • View Affiliations / Copyright

    Affiliations: The Anticancer Resistance Research Group and the Center for Cancer Biology, Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
  • Pages: 1413-1419
    |
    Published online on: December 1, 2006
       https://doi.org/10.3892/ijo.29.6.1413
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Abstract

The human P-glycoprotein (Pgp) is a drug-efflux pump responsible for innate or acquired multidrug resistance in many cancers. Pgp contains a unique ≈75 amino acid long linker region in its middle, which is critically important for its drug transport and ATPase functions. To identify cellular proteins that bind to this linker region and modulate Pgp function, a yeast two-hybrid analysis was carried out. This procedure identified RNF2 (RING finger protein 2), an E3 ubiquitin ligase, as a prominent Pgp-interacting protein. Co-expression of RNF2 with Pgp in Sf9 insect cells resulted in decreased ATPase activity and proteolytic protection of the transporter protein. Immunoprecipitation experiments confirmed the physical interaction between these two proteins. Confocal microscopy showed the presence of RNF2 in the cytoplasm of the Pgp-negative, drug-sensitive MCF-7 breast cancer cells. However, it was undetectable in the Pgp-positive and drug-resistant MCF-7 cells. We suggest that RNF2 regulates the cellular abundance of Pgp, and plays a key role in the development of cancer drug resistance through its own down-regulation.

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Copy and paste a formatted citation
Spandidos Publications style
Rao PS, Mallya KB, Srivenugopal KS, Balaji KC and Rao US: RNF2 interacts with the linker region of the human P-glycoprotein. Int J Oncol 29: 1413-1419, 2006.
APA
Rao, P.S., Mallya, K.B., Srivenugopal, K.S., Balaji, K.C., & Rao, U.S. (2006). RNF2 interacts with the linker region of the human P-glycoprotein. International Journal of Oncology, 29, 1413-1419. https://doi.org/10.3892/ijo.29.6.1413
MLA
Rao, P. S., Mallya, K. B., Srivenugopal, K. S., Balaji, K. C., Rao, U. S."RNF2 interacts with the linker region of the human P-glycoprotein". International Journal of Oncology 29.6 (2006): 1413-1419.
Chicago
Rao, P. S., Mallya, K. B., Srivenugopal, K. S., Balaji, K. C., Rao, U. S."RNF2 interacts with the linker region of the human P-glycoprotein". International Journal of Oncology 29, no. 6 (2006): 1413-1419. https://doi.org/10.3892/ijo.29.6.1413
Copy and paste a formatted citation
x
Spandidos Publications style
Rao PS, Mallya KB, Srivenugopal KS, Balaji KC and Rao US: RNF2 interacts with the linker region of the human P-glycoprotein. Int J Oncol 29: 1413-1419, 2006.
APA
Rao, P.S., Mallya, K.B., Srivenugopal, K.S., Balaji, K.C., & Rao, U.S. (2006). RNF2 interacts with the linker region of the human P-glycoprotein. International Journal of Oncology, 29, 1413-1419. https://doi.org/10.3892/ijo.29.6.1413
MLA
Rao, P. S., Mallya, K. B., Srivenugopal, K. S., Balaji, K. C., Rao, U. S."RNF2 interacts with the linker region of the human P-glycoprotein". International Journal of Oncology 29.6 (2006): 1413-1419.
Chicago
Rao, P. S., Mallya, K. B., Srivenugopal, K. S., Balaji, K. C., Rao, U. S."RNF2 interacts with the linker region of the human P-glycoprotein". International Journal of Oncology 29, no. 6 (2006): 1413-1419. https://doi.org/10.3892/ijo.29.6.1413
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