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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2006 Volume 29 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2006 Volume 29 Issue 6

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Article

CHK negatively regulates Lyn kinase and suppresses pancreatic cancer cell invasion

  • Authors:
    • Yigong Fu
    • Radoslaw Zagozdzon
    • Ron Avraham
    • Hava Karsenty Avraham

  • View Affiliations / Copyright

    Affiliations: Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
  • Pages: 1453-1458
    |
    Published online on: December 1, 2006
       https://doi.org/10.3892/ijo.29.6.1453
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Abstract

Among the most important signaling pathways operating in pancreatic cancer cells are those resulting from mutations in the Ras oncogene or from overexpression of ErbB-2 and associated Src-family kinases. In this study, we aimed to characterize CHK expression and function in pancreatic cancer. Our data demonstrated CHK expression in human pancreatic cancer tissues, and also showed that CHK associated with ErbB-2 via its SH2 domain in human PANC-1 pancreatic cancer cells. PANC-1 cells were found to express both Src kinase and Lyn kinase, although the expression of Lyn kinase was more abundant. Furthermore, CHK downregulated Lyn kinase activity and significantly inhibited the in vitro growth and invasion of PANC-1 cells upon EGF stimulation. These results indicate that CHK is a negative regulator of ErbB-2 and Lyn kinase signaling in pancreatic cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Fu Y, Zagozdzon R, Avraham R and Avraham HK: CHK negatively regulates Lyn kinase and suppresses pancreatic cancer cell invasion. Int J Oncol 29: 1453-1458, 2006.
APA
Fu, Y., Zagozdzon, R., Avraham, R., & Avraham, H.K. (2006). CHK negatively regulates Lyn kinase and suppresses pancreatic cancer cell invasion. International Journal of Oncology, 29, 1453-1458. https://doi.org/10.3892/ijo.29.6.1453
MLA
Fu, Y., Zagozdzon, R., Avraham, R., Avraham, H. K."CHK negatively regulates Lyn kinase and suppresses pancreatic cancer cell invasion". International Journal of Oncology 29.6 (2006): 1453-1458.
Chicago
Fu, Y., Zagozdzon, R., Avraham, R., Avraham, H. K."CHK negatively regulates Lyn kinase and suppresses pancreatic cancer cell invasion". International Journal of Oncology 29, no. 6 (2006): 1453-1458. https://doi.org/10.3892/ijo.29.6.1453
Copy and paste a formatted citation
x
Spandidos Publications style
Fu Y, Zagozdzon R, Avraham R and Avraham HK: CHK negatively regulates Lyn kinase and suppresses pancreatic cancer cell invasion. Int J Oncol 29: 1453-1458, 2006.
APA
Fu, Y., Zagozdzon, R., Avraham, R., & Avraham, H.K. (2006). CHK negatively regulates Lyn kinase and suppresses pancreatic cancer cell invasion. International Journal of Oncology, 29, 1453-1458. https://doi.org/10.3892/ijo.29.6.1453
MLA
Fu, Y., Zagozdzon, R., Avraham, R., Avraham, H. K."CHK negatively regulates Lyn kinase and suppresses pancreatic cancer cell invasion". International Journal of Oncology 29.6 (2006): 1453-1458.
Chicago
Fu, Y., Zagozdzon, R., Avraham, R., Avraham, H. K."CHK negatively regulates Lyn kinase and suppresses pancreatic cancer cell invasion". International Journal of Oncology 29, no. 6 (2006): 1453-1458. https://doi.org/10.3892/ijo.29.6.1453
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