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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2006 Volume 29 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2006 Volume 29 Issue 6

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Article

Perturbation of polyamine metabolism and its relation to cell death in human colon cancer cells treated by 7β-hydroxycholesterol and 7β-hydroxysitosterol

  • Authors:
    • Stamatiki Roussi
    • Francine Gossé
    • Dalal Aoudé-Werner
    • Xin Zhang
    • Philippe Geoffroy
    • Michel Miesch
    • Eric Marchioni
    • Francis Raul

  • View Affiliations / Copyright

    Affiliations: INSERM U682, Université Louis-Pasteur EA3430, Faculté of Médecine, Laboratoire de Prévention Nutritionnelle du Cancer, IRCAD, 67092 Strasbourg, France
  • Pages: 1549-1554
    |
    Published online on: December 1, 2006
       https://doi.org/10.3892/ijo.29.6.1549
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Abstract

7β-OHsitosterol and 7β-OHcholesterol are natural compounds of plant and animal cells with high structural similarity. Recently it was reported that both compounds induced apoptosis on human colon cancer cells by targeting different signalling pathways. Our study aimed at comparing their effects on polyamine metabolism and its relation to apoptosis. When human colon cancer cells were exposed to 7β-OHsitosterol and to 7β-OHcholesterol at concentrations inhibiting growth by the same degree, both compounds caused a reduction of polyamine biosynthetic enzyme activity, of the polyamine pools, and an increase of N1-acetylspermidine concentration indicating the enhancement of polyamine catabolism. Exogenous putrescine did not prevent cell death caused by 7β-OHsitosterol, whereas 7β-OHcholesterol-induced apoptosis was inhibited. MDL 72527, an inhibitor of polyamine oxidase, an enzyme of the polyamine catabolic pathway, potentiated the antiproliferative effects of 7β-OHcholesterol by increasing the N1-acetylspermidine pool and enhanced the accumulation of apoptotic cells. In contrast, MDL 72527 did not change the apoptosis rate and the N1-acetylspermidine content in cells treated with 7β-OHsitosterol. These data indicate that polyamine metabolic perturbations triggered by 7β-OHcholesterol but not by 7β-OHsitosterol are related to cell death.

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Copy and paste a formatted citation
Spandidos Publications style
Roussi S, Gossé F, Aoudé-Werner D, Zhang X, Geoffroy P, Miesch M, Marchioni E and Raul F: Perturbation of polyamine metabolism and its relation to cell death in human colon cancer cells treated by 7β-hydroxycholesterol and 7β-hydroxysitosterol. Int J Oncol 29: 1549-1554, 2006.
APA
Roussi, S., Gossé, F., Aoudé-Werner, D., Zhang, X., Geoffroy, P., Miesch, M. ... Raul, F. (2006). Perturbation of polyamine metabolism and its relation to cell death in human colon cancer cells treated by 7β-hydroxycholesterol and 7β-hydroxysitosterol. International Journal of Oncology, 29, 1549-1554. https://doi.org/10.3892/ijo.29.6.1549
MLA
Roussi, S., Gossé, F., Aoudé-Werner, D., Zhang, X., Geoffroy, P., Miesch, M., Marchioni, E., Raul, F."Perturbation of polyamine metabolism and its relation to cell death in human colon cancer cells treated by 7β-hydroxycholesterol and 7β-hydroxysitosterol". International Journal of Oncology 29.6 (2006): 1549-1554.
Chicago
Roussi, S., Gossé, F., Aoudé-Werner, D., Zhang, X., Geoffroy, P., Miesch, M., Marchioni, E., Raul, F."Perturbation of polyamine metabolism and its relation to cell death in human colon cancer cells treated by 7β-hydroxycholesterol and 7β-hydroxysitosterol". International Journal of Oncology 29, no. 6 (2006): 1549-1554. https://doi.org/10.3892/ijo.29.6.1549
Copy and paste a formatted citation
x
Spandidos Publications style
Roussi S, Gossé F, Aoudé-Werner D, Zhang X, Geoffroy P, Miesch M, Marchioni E and Raul F: Perturbation of polyamine metabolism and its relation to cell death in human colon cancer cells treated by 7β-hydroxycholesterol and 7β-hydroxysitosterol. Int J Oncol 29: 1549-1554, 2006.
APA
Roussi, S., Gossé, F., Aoudé-Werner, D., Zhang, X., Geoffroy, P., Miesch, M. ... Raul, F. (2006). Perturbation of polyamine metabolism and its relation to cell death in human colon cancer cells treated by 7β-hydroxycholesterol and 7β-hydroxysitosterol. International Journal of Oncology, 29, 1549-1554. https://doi.org/10.3892/ijo.29.6.1549
MLA
Roussi, S., Gossé, F., Aoudé-Werner, D., Zhang, X., Geoffroy, P., Miesch, M., Marchioni, E., Raul, F."Perturbation of polyamine metabolism and its relation to cell death in human colon cancer cells treated by 7β-hydroxycholesterol and 7β-hydroxysitosterol". International Journal of Oncology 29.6 (2006): 1549-1554.
Chicago
Roussi, S., Gossé, F., Aoudé-Werner, D., Zhang, X., Geoffroy, P., Miesch, M., Marchioni, E., Raul, F."Perturbation of polyamine metabolism and its relation to cell death in human colon cancer cells treated by 7β-hydroxycholesterol and 7β-hydroxysitosterol". International Journal of Oncology 29, no. 6 (2006): 1549-1554. https://doi.org/10.3892/ijo.29.6.1549
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