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DUODENAL 7-ETHOXYCOUMARIN-O-DEETHYLASE ACTIVITY IN COLON-CANCER PATIENTS

  • Authors:
    • A CATS
    • JH KLEIBEUKER
    • W BOERSMA
    • EGE DEVRIES
    • WJ SLUITER
    • JG BOUMAN
    • DT SLEIJFER
    • NH MULDER

  • View Affiliations

  • Published online on: July 1, 1993     https://doi.org/10.3892/ijo.3.1.47
  • Pages: 47-51
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Abstract

The biotransformation activity of the mono-oxygenase enzyme, 7-ethoxycoumarin-O-deethylase (EOD), was investigated in the upper digestive tract of colon cancer patients, and compared with patients with and without neoplasia. The three groups studied comprised 23 control, 17 metastasized colon cancer and 16 metastasized breast cancer patients. EOD activity was determined by spectrofluorometry in duodenal biopsies obtained during gastroduodenoscopy. No correlation between the presence of colon or breast cancer and the level of EOD activity was observed. It was concluded that biotransformation enzymes can be easily determined in duodenal biopsies derived during. gastroduodenoscopy. The role of EOD in the biogenesis of colon cancer seems to be limited.

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July 1993
Volume 3 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Impact Factor: 5.2
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  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
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Spandidos Publications style
CATS A, KLEIBEUKER J, BOERSMA W, DEVRIES E, SLUITER W, BOUMAN J, SLEIJFER D and MULDER N: DUODENAL 7-ETHOXYCOUMARIN-O-DEETHYLASE ACTIVITY IN COLON-CANCER PATIENTS. Int J Oncol 3: 47-51, 1993
APA
CATS, A., KLEIBEUKER, J., BOERSMA, W., DEVRIES, E., SLUITER, W., BOUMAN, J. ... MULDER, N. (1993). DUODENAL 7-ETHOXYCOUMARIN-O-DEETHYLASE ACTIVITY IN COLON-CANCER PATIENTS. International Journal of Oncology, 3, 47-51. https://doi.org/10.3892/ijo.3.1.47
MLA
CATS, A., KLEIBEUKER, J., BOERSMA, W., DEVRIES, E., SLUITER, W., BOUMAN, J., SLEIJFER, D., MULDER, N."DUODENAL 7-ETHOXYCOUMARIN-O-DEETHYLASE ACTIVITY IN COLON-CANCER PATIENTS". International Journal of Oncology 3.1 (1993): 47-51.
Chicago
CATS, A., KLEIBEUKER, J., BOERSMA, W., DEVRIES, E., SLUITER, W., BOUMAN, J., SLEIJFER, D., MULDER, N."DUODENAL 7-ETHOXYCOUMARIN-O-DEETHYLASE ACTIVITY IN COLON-CANCER PATIENTS". International Journal of Oncology 3, no. 1 (1993): 47-51. https://doi.org/10.3892/ijo.3.1.47