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INVOLVEMENT OF ANTIOXIDANT ENZYMES IN MULTIPLE-DRUG RESISTANCE IN A HUMAN T-LYMPHOBLASTIC LEUKEMIA-CELL LINE WHICH OVER-EXPRESSES P-GLYCOPROTEIN

  • Authors:
    • M YANG
    • XR JIANG
    • DR BLAKE
    • Z ZHANG
    • MG MACEY
    • AC NEWLAND
    • CJ MORRIS

  • View Affiliations

  • Published online on: July 1, 1993     https://doi.org/10.3892/ijo.3.1.99
  • Pages: 99-104
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Abstract

We have compared the specific activities of Cu/Zn superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in a vinblastine sensitive human T-lymphoblastic cell line (CCRF-CEM) and its multiple drug resistant (MDR) counterpart cell line (CEM/VLB100), which over-expresses P-glycoprotein (PGP). We have found that the specific activity Cu/Zn SOD was consistently 38% increased in CEM/VLB100 cells compared with CCRF-CEM cells. In contrast, the activities of CAT and GSH-Px were similar in the two cell lines. These results suggest that MDR in CEM/VLB100 is a complicated phenotype which not only involves a PGP mechanism, but also a SOD protection mechanism against drug-mediated O2.- cytotoxicity.

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July 1993
Volume 3 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Impact Factor: 5.2
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  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
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Spandidos Publications style
YANG M, JIANG X, BLAKE D, ZHANG Z, MACEY M, NEWLAND A and MORRIS C: INVOLVEMENT OF ANTIOXIDANT ENZYMES IN MULTIPLE-DRUG RESISTANCE IN A HUMAN T-LYMPHOBLASTIC LEUKEMIA-CELL LINE WHICH OVER-EXPRESSES P-GLYCOPROTEIN. Int J Oncol 3: 99-104, 1993
APA
YANG, M., JIANG, X., BLAKE, D., ZHANG, Z., MACEY, M., NEWLAND, A., & MORRIS, C. (1993). INVOLVEMENT OF ANTIOXIDANT ENZYMES IN MULTIPLE-DRUG RESISTANCE IN A HUMAN T-LYMPHOBLASTIC LEUKEMIA-CELL LINE WHICH OVER-EXPRESSES P-GLYCOPROTEIN. International Journal of Oncology, 3, 99-104. https://doi.org/10.3892/ijo.3.1.99
MLA
YANG, M., JIANG, X., BLAKE, D., ZHANG, Z., MACEY, M., NEWLAND, A., MORRIS, C."INVOLVEMENT OF ANTIOXIDANT ENZYMES IN MULTIPLE-DRUG RESISTANCE IN A HUMAN T-LYMPHOBLASTIC LEUKEMIA-CELL LINE WHICH OVER-EXPRESSES P-GLYCOPROTEIN". International Journal of Oncology 3.1 (1993): 99-104.
Chicago
YANG, M., JIANG, X., BLAKE, D., ZHANG, Z., MACEY, M., NEWLAND, A., MORRIS, C."INVOLVEMENT OF ANTIOXIDANT ENZYMES IN MULTIPLE-DRUG RESISTANCE IN A HUMAN T-LYMPHOBLASTIC LEUKEMIA-CELL LINE WHICH OVER-EXPRESSES P-GLYCOPROTEIN". International Journal of Oncology 3, no. 1 (1993): 99-104. https://doi.org/10.3892/ijo.3.1.99