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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 1993 Volume 3 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August 1993 Volume 3 Issue 2

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Article

TUMOR-SPECIFIC DEMETHYLATION OF HETEROCHROMATIC REPETITIVE DNA IN GASTROINTESTINAL CANCER

  • Authors:
    • K HOLZMANN
    • R MULLENBACH
    • N BLIN
  • View Affiliations / Copyright

    Affiliations: Affliations not specified
  • Pages: 261-264
    |
    Published online on: August 1, 1993
       https://doi.org/10.3892/ijo.3.2.261
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Abstract

DNA methylation appears to play an important role in both physiological and experimentally modified gene expression. Alterations in DNA methylation have been described in animal tumour models, in transformed cells and tumour cell lines, usually for single copy DNA sequences. By applying the isoschizomeres HpaII and MspI the methylation status of two classes of repetitive sequences (D22Z2 - a member of the alphoid repeats and D22Z3 which belongs to the HinfI repeats) in colon and stomach carcinoma were tested. A strong demethylation of both types of repetitive sequences in stomach carcinoma in comparison to healthy stomach mucosa was detected. In colon carcinoma, only minor signs of demethylation occured for the same repetitive DNA.

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Copy and paste a formatted citation
Spandidos Publications style
HOLZMANN K, MULLENBACH R and BLIN N: TUMOR-SPECIFIC DEMETHYLATION OF HETEROCHROMATIC REPETITIVE DNA IN GASTROINTESTINAL CANCER. Int J Oncol 3: 261-264, 1993.
APA
HOLZMANN, K., MULLENBACH, R., & BLIN, N. (1993). TUMOR-SPECIFIC DEMETHYLATION OF HETEROCHROMATIC REPETITIVE DNA IN GASTROINTESTINAL CANCER. International Journal of Oncology, 3, 261-264. https://doi.org/10.3892/ijo.3.2.261
MLA
HOLZMANN, K., MULLENBACH, R., BLIN, N."TUMOR-SPECIFIC DEMETHYLATION OF HETEROCHROMATIC REPETITIVE DNA IN GASTROINTESTINAL CANCER". International Journal of Oncology 3.2 (1993): 261-264.
Chicago
HOLZMANN, K., MULLENBACH, R., BLIN, N."TUMOR-SPECIFIC DEMETHYLATION OF HETEROCHROMATIC REPETITIVE DNA IN GASTROINTESTINAL CANCER". International Journal of Oncology 3, no. 2 (1993): 261-264. https://doi.org/10.3892/ijo.3.2.261
Copy and paste a formatted citation
x
Spandidos Publications style
HOLZMANN K, MULLENBACH R and BLIN N: TUMOR-SPECIFIC DEMETHYLATION OF HETEROCHROMATIC REPETITIVE DNA IN GASTROINTESTINAL CANCER. Int J Oncol 3: 261-264, 1993.
APA
HOLZMANN, K., MULLENBACH, R., & BLIN, N. (1993). TUMOR-SPECIFIC DEMETHYLATION OF HETEROCHROMATIC REPETITIVE DNA IN GASTROINTESTINAL CANCER. International Journal of Oncology, 3, 261-264. https://doi.org/10.3892/ijo.3.2.261
MLA
HOLZMANN, K., MULLENBACH, R., BLIN, N."TUMOR-SPECIFIC DEMETHYLATION OF HETEROCHROMATIC REPETITIVE DNA IN GASTROINTESTINAL CANCER". International Journal of Oncology 3.2 (1993): 261-264.
Chicago
HOLZMANN, K., MULLENBACH, R., BLIN, N."TUMOR-SPECIFIC DEMETHYLATION OF HETEROCHROMATIC REPETITIVE DNA IN GASTROINTESTINAL CANCER". International Journal of Oncology 3, no. 2 (1993): 261-264. https://doi.org/10.3892/ijo.3.2.261
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