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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 1993 Volume 3 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 1993 Volume 3 Issue 2

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Article

DEVELOPMENT AND CHARACTERIZATION OF AN ADRIAMYCIN-RESISTANT SW480 HUMAN COLON ADENOCARCINOMA CELL-LINE

  • Authors:
    • WHM PETERS
    • HMJ ROELOFS

  • View Affiliations / Copyright

    Affiliations: Affliations not specified
  • Pages: 287-291
    |
    Published online on: August 1, 1993
       https://doi.org/10.3892/ijo.3.2.287
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Abstract

An adriamycin resistant Sw480 human colon adenocarcinoma cell line (Sw480 Adr) was developed. Characteristics of the Sw480 Adr cells were compared with that of the parent Sw480 (Sw480 WT) cell line. Sw480 Adr cells were cross-resistant to mitoxantrone but not to cisplatin. Glutathione S-transferase enzyme activity as well as glutathione S-transferase pi content were increased 1.5 fold in the resistant cells, whereas P-170 glycoprotein content was increased several hundredfold. Sw480 Adr cells could be partly resensitised towards adriamycin by prior incubation with verapamil (1.65-3.3 mug/ml) and completely resensitised by cyclosporin A (2.5-5.0 mug/ml). Incubation of Sw480 Adr cells with various concentrations of adriamycin (200-1600 nM) during one week, did not change the P-170 glycoprotein levels. In addition, Sw480 Adr cells cultured in adriamycin-free medium for ten weeks (and passaged each week), showed no significant change in P-170 glycoprotein content. These results indicate that the most important mechanism for adriamycin resistance in Sw480 Adr human colon adenocarcinoma cells is overexpression of the P-170 glycoprotein, an ATP-driven drug efflux pump located in the plasma membrane. This overexpression of the P-170 glycoprotein in Sw480 Adr cells does not seem to be reversible.

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Copy and paste a formatted citation
Spandidos Publications style
PETERS W and ROELOFS H: DEVELOPMENT AND CHARACTERIZATION OF AN ADRIAMYCIN-RESISTANT SW480 HUMAN COLON ADENOCARCINOMA CELL-LINE. Int J Oncol 3: 287-291, 1993.
APA
PETERS, W., & ROELOFS, H. (1993). DEVELOPMENT AND CHARACTERIZATION OF AN ADRIAMYCIN-RESISTANT SW480 HUMAN COLON ADENOCARCINOMA CELL-LINE. International Journal of Oncology, 3, 287-291. https://doi.org/10.3892/ijo.3.2.287
MLA
PETERS, W., ROELOFS, H."DEVELOPMENT AND CHARACTERIZATION OF AN ADRIAMYCIN-RESISTANT SW480 HUMAN COLON ADENOCARCINOMA CELL-LINE". International Journal of Oncology 3.2 (1993): 287-291.
Chicago
PETERS, W., ROELOFS, H."DEVELOPMENT AND CHARACTERIZATION OF AN ADRIAMYCIN-RESISTANT SW480 HUMAN COLON ADENOCARCINOMA CELL-LINE". International Journal of Oncology 3, no. 2 (1993): 287-291. https://doi.org/10.3892/ijo.3.2.287
Copy and paste a formatted citation
x
Spandidos Publications style
PETERS W and ROELOFS H: DEVELOPMENT AND CHARACTERIZATION OF AN ADRIAMYCIN-RESISTANT SW480 HUMAN COLON ADENOCARCINOMA CELL-LINE. Int J Oncol 3: 287-291, 1993.
APA
PETERS, W., & ROELOFS, H. (1993). DEVELOPMENT AND CHARACTERIZATION OF AN ADRIAMYCIN-RESISTANT SW480 HUMAN COLON ADENOCARCINOMA CELL-LINE. International Journal of Oncology, 3, 287-291. https://doi.org/10.3892/ijo.3.2.287
MLA
PETERS, W., ROELOFS, H."DEVELOPMENT AND CHARACTERIZATION OF AN ADRIAMYCIN-RESISTANT SW480 HUMAN COLON ADENOCARCINOMA CELL-LINE". International Journal of Oncology 3.2 (1993): 287-291.
Chicago
PETERS, W., ROELOFS, H."DEVELOPMENT AND CHARACTERIZATION OF AN ADRIAMYCIN-RESISTANT SW480 HUMAN COLON ADENOCARCINOMA CELL-LINE". International Journal of Oncology 3, no. 2 (1993): 287-291. https://doi.org/10.3892/ijo.3.2.287
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