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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 1993 Volume 3 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August 1993 Volume 3 Issue 2

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Article

ANALYSIS BY SOMATIC-CELL FUSION OF THE PHENOTYPIC PROPERTIES OF A MUTANT EMBRYONAL CARCINOMA CELL-LINE

  • Authors:
    • N AZIZ
    • J DIETRICH
    • HS SHIN
    • PJ MCCORMICK

  • View Affiliations / Copyright

    Affiliations: SUNY,DEPT BIOL SCI,CTR CELLULAR DIFFERENTIAT,1400 WASHINGTON AVE,ALBANY,NY 12222. BRIGHAM & WOMENS HOSP,DEPT MED,DIV RENAL,BOSTON,MA 02115. HARVARD UNIV,SCH MED,HARVARD CTR STUDY KIDNEY DIS,BOSTON,MA 02115. POHANG INST SCI & TECHNOL,DEPT LIFE SCI,KYUNGBUK 790330,SOUTH KOREA.
  • Pages: 313-318
    |
    Published online on: August 1, 1993
       https://doi.org/10.3892/ijo.3.2.313
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Abstract

We have previously reported the isolation of an embryonal carcinoma (EC) cell mutant created via retroviral insertion (1). The mutant (NR1-6) is aberrant in respect to morphology, tumorigenicity and response to retinoic acid (RA). In order to determine the dominance/recessive hierarchy and genetic relationships of these phenotypes, we created hybrid lines from mutant and parental cells. Three hybrid clones (Hyb 1, 2a and 2b), which retain both mutant and parental loci, were analyzed. Our results indicate that in all parameters - morphology, adhesion, qualitative and quantitative response to RA and tumorigenicity - the hybrids behave similarly to parental cells. In no case did any of the hybrid lines exhibit a mutant phenotype. The data indicate that the phenotypes we have studied are genetically interrelated and that the parental characteristics are dominant.

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Copy and paste a formatted citation
Spandidos Publications style
AZIZ N, DIETRICH J, SHIN H and MCCORMICK P: ANALYSIS BY SOMATIC-CELL FUSION OF THE PHENOTYPIC PROPERTIES OF A MUTANT EMBRYONAL CARCINOMA CELL-LINE. Int J Oncol 3: 313-318, 1993.
APA
AZIZ, N., DIETRICH, J., SHIN, H., & MCCORMICK, P. (1993). ANALYSIS BY SOMATIC-CELL FUSION OF THE PHENOTYPIC PROPERTIES OF A MUTANT EMBRYONAL CARCINOMA CELL-LINE. International Journal of Oncology, 3, 313-318. https://doi.org/10.3892/ijo.3.2.313
MLA
AZIZ, N., DIETRICH, J., SHIN, H., MCCORMICK, P."ANALYSIS BY SOMATIC-CELL FUSION OF THE PHENOTYPIC PROPERTIES OF A MUTANT EMBRYONAL CARCINOMA CELL-LINE". International Journal of Oncology 3.2 (1993): 313-318.
Chicago
AZIZ, N., DIETRICH, J., SHIN, H., MCCORMICK, P."ANALYSIS BY SOMATIC-CELL FUSION OF THE PHENOTYPIC PROPERTIES OF A MUTANT EMBRYONAL CARCINOMA CELL-LINE". International Journal of Oncology 3, no. 2 (1993): 313-318. https://doi.org/10.3892/ijo.3.2.313
Copy and paste a formatted citation
x
Spandidos Publications style
AZIZ N, DIETRICH J, SHIN H and MCCORMICK P: ANALYSIS BY SOMATIC-CELL FUSION OF THE PHENOTYPIC PROPERTIES OF A MUTANT EMBRYONAL CARCINOMA CELL-LINE. Int J Oncol 3: 313-318, 1993.
APA
AZIZ, N., DIETRICH, J., SHIN, H., & MCCORMICK, P. (1993). ANALYSIS BY SOMATIC-CELL FUSION OF THE PHENOTYPIC PROPERTIES OF A MUTANT EMBRYONAL CARCINOMA CELL-LINE. International Journal of Oncology, 3, 313-318. https://doi.org/10.3892/ijo.3.2.313
MLA
AZIZ, N., DIETRICH, J., SHIN, H., MCCORMICK, P."ANALYSIS BY SOMATIC-CELL FUSION OF THE PHENOTYPIC PROPERTIES OF A MUTANT EMBRYONAL CARCINOMA CELL-LINE". International Journal of Oncology 3.2 (1993): 313-318.
Chicago
AZIZ, N., DIETRICH, J., SHIN, H., MCCORMICK, P."ANALYSIS BY SOMATIC-CELL FUSION OF THE PHENOTYPIC PROPERTIES OF A MUTANT EMBRYONAL CARCINOMA CELL-LINE". International Journal of Oncology 3, no. 2 (1993): 313-318. https://doi.org/10.3892/ijo.3.2.313
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