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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 1993 Volume 3 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 1993 Volume 3 Issue 2

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FACTORS SECRETED BY TUMOR-TRANSFORMED FIBROBLASTS ELEVATE THE ACTIVITY OF HMG COA REDUCTASE - CORRELATION TO THE STIMULATIVE EFFECT ON DNA-SYNTHESIS

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    • O LARSSON

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  • Pages: 361-364
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    Published online on: August 1, 1993
       https://doi.org/10.3892/ijo.3.2.361
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Abstract

Serum-free conditioned medium from virus-transformed murine and human fibroblasts (SV3T3 and 90VAVI) substantially increased the activity of HMG CoA reductase in normal cells (3T3 and HDF, respectively). The conditioned medium also stimulated normal cells to initiate DNA synthesis. Addition of mevinolin (an HMG CoA reductase inhibitor) depressed this increase in HMG CoA reductase activity with similar kinetics as it did in the transformed cells as well as in serum-stimulated normal cells. Whereas mevinolin efficiently blocked the proliferation of serum-stimulated normal fibroblasts, it only caused a partial growth inhibition in cells treated with conditioned medium. Likewise mevinolin failed to block the proliferation of the transformed cells. Taken together the present data suggest that virus-transformed fibroblasts produce and secrete factors stimulating mevalonate-dependent cell growth by two different mechanisms. Whereas some factors exert their stimulative effects on DNA synthesis by elevating the activity of HMG CoA reductase (secreted PDGF-like proteins may act in this manner), others may. mediate their growth stimulative effect by increasing the utilization of existing mevalonate in the production of growth regulatory metabolites.

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Copy and paste a formatted citation
Spandidos Publications style
LARSSON O: FACTORS SECRETED BY TUMOR-TRANSFORMED FIBROBLASTS ELEVATE THE ACTIVITY OF HMG COA REDUCTASE - CORRELATION TO THE STIMULATIVE EFFECT ON DNA-SYNTHESIS. Int J Oncol 3: 361-364, 1993.
APA
LARSSON, O. (1993). FACTORS SECRETED BY TUMOR-TRANSFORMED FIBROBLASTS ELEVATE THE ACTIVITY OF HMG COA REDUCTASE - CORRELATION TO THE STIMULATIVE EFFECT ON DNA-SYNTHESIS. International Journal of Oncology, 3, 361-364. https://doi.org/10.3892/ijo.3.2.361
MLA
LARSSON, O."FACTORS SECRETED BY TUMOR-TRANSFORMED FIBROBLASTS ELEVATE THE ACTIVITY OF HMG COA REDUCTASE - CORRELATION TO THE STIMULATIVE EFFECT ON DNA-SYNTHESIS". International Journal of Oncology 3.2 (1993): 361-364.
Chicago
LARSSON, O."FACTORS SECRETED BY TUMOR-TRANSFORMED FIBROBLASTS ELEVATE THE ACTIVITY OF HMG COA REDUCTASE - CORRELATION TO THE STIMULATIVE EFFECT ON DNA-SYNTHESIS". International Journal of Oncology 3, no. 2 (1993): 361-364. https://doi.org/10.3892/ijo.3.2.361
Copy and paste a formatted citation
x
Spandidos Publications style
LARSSON O: FACTORS SECRETED BY TUMOR-TRANSFORMED FIBROBLASTS ELEVATE THE ACTIVITY OF HMG COA REDUCTASE - CORRELATION TO THE STIMULATIVE EFFECT ON DNA-SYNTHESIS. Int J Oncol 3: 361-364, 1993.
APA
LARSSON, O. (1993). FACTORS SECRETED BY TUMOR-TRANSFORMED FIBROBLASTS ELEVATE THE ACTIVITY OF HMG COA REDUCTASE - CORRELATION TO THE STIMULATIVE EFFECT ON DNA-SYNTHESIS. International Journal of Oncology, 3, 361-364. https://doi.org/10.3892/ijo.3.2.361
MLA
LARSSON, O."FACTORS SECRETED BY TUMOR-TRANSFORMED FIBROBLASTS ELEVATE THE ACTIVITY OF HMG COA REDUCTASE - CORRELATION TO THE STIMULATIVE EFFECT ON DNA-SYNTHESIS". International Journal of Oncology 3.2 (1993): 361-364.
Chicago
LARSSON, O."FACTORS SECRETED BY TUMOR-TRANSFORMED FIBROBLASTS ELEVATE THE ACTIVITY OF HMG COA REDUCTASE - CORRELATION TO THE STIMULATIVE EFFECT ON DNA-SYNTHESIS". International Journal of Oncology 3, no. 2 (1993): 361-364. https://doi.org/10.3892/ijo.3.2.361
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