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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 1993 Volume 3 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August 1993 Volume 3 Issue 2

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Article

COMPARISON OF CYTOTOXICITY AND CELL KINETIC PERTURBATIONS OF 5 PLATINUM COMPOUNDS IN GYNECOLOGIC CANCER CELL-LINES

  • Authors:
    • HN NGUYEN
    • BU SEVIN
    • HE AVERETTE
    • J PERRAS
    • R RAMOS
    • R ANGIOLI
    • K OCHIAI

  • View Affiliations / Copyright

    Affiliations: UNIV MIAMI,SCH MED,DEPT OBSTET & GYNECOL,DIV GYNECOL ONCOL,MIAMI,FL 33101. UNIV ROMA LA SAPIENZA,OSTET GINEC CLIN 1,I-00185 ROME,ITALY. JIKEI UNIV SCH MED,DEPT OBSTET & GYNECOL,DIV GYNECOL ONCOL,TOKYO 105,JAPAN.
  • Pages: 375-382
    |
    Published online on: August 1, 1993
       https://doi.org/10.3892/ijo.3.2.375
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Abstract

New platinum derivatives were synthesized to overcome problems of cisplatin resistance and nephrotoxicity. Five platinum derivatives were evaluated by using the ATP chemosensitivity assay and flow cytometry in a panel of 10 human gynecologic cancer cell lines: AE7, ECC1, HEC1A, HEC1B, AN3, BG1, CAOV3, SKOV3, SKUT1B and ME180. Five platinum derivatives and their referenced concentrations (X) were: Cisplatin (DDP) 2.5 mug/ml (8.3 muM), Carboplatin (CARBO) 28 mug/ml (75.5 muM), Tetraplatin (TETRA) 2 mug/ml (4.4 muM), 254S at 5 mug/ml (16.5 muM) and NK121 at 5 mug/ml (11.4 muM). Drug exposure was performed at 0, 0.1, 0.2, 0.5, 1, 2 and 5 X for 90 minutes. The ATP chemosensitivity assay was performed on day 7 as previously described. Cell samples were taken at 0, 24, 48, 72, 96 and 168 h timepoints for flow cytometry. Mean IC50s were: DDP 29.1+/-17.4 muM, 254S 18.2+/-6.6 muM, NK121 13.7+/-5.7 muM, CARBO 120.8+/-37.8 muM, and TETRA 30.8+/-20.7 muM. Both 254S and NK121 offered significant improvement of potency over DDP (p=0.02, 0.05 respectively). Similarly, Fell cycle kinetic studies revealed that both 254S and NK121 induced significantly more S and G2 blocks than DDP (p<0.02). Thus, from the chemo-sensitivity and cell kinetic standpoints, both NK121 and 254S appeared more potent and deserve further investigation.

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Copy and paste a formatted citation
Spandidos Publications style
NGUYEN H, SEVIN B, AVERETTE H, PERRAS J, RAMOS R, ANGIOLI R and OCHIAI K: COMPARISON OF CYTOTOXICITY AND CELL KINETIC PERTURBATIONS OF 5 PLATINUM COMPOUNDS IN GYNECOLOGIC CANCER CELL-LINES. Int J Oncol 3: 375-382, 1993.
APA
NGUYEN, H., SEVIN, B., AVERETTE, H., PERRAS, J., RAMOS, R., ANGIOLI, R., & OCHIAI, K. (1993). COMPARISON OF CYTOTOXICITY AND CELL KINETIC PERTURBATIONS OF 5 PLATINUM COMPOUNDS IN GYNECOLOGIC CANCER CELL-LINES. International Journal of Oncology, 3, 375-382. https://doi.org/10.3892/ijo.3.2.375
MLA
NGUYEN, H., SEVIN, B., AVERETTE, H., PERRAS, J., RAMOS, R., ANGIOLI, R., OCHIAI, K."COMPARISON OF CYTOTOXICITY AND CELL KINETIC PERTURBATIONS OF 5 PLATINUM COMPOUNDS IN GYNECOLOGIC CANCER CELL-LINES". International Journal of Oncology 3.2 (1993): 375-382.
Chicago
NGUYEN, H., SEVIN, B., AVERETTE, H., PERRAS, J., RAMOS, R., ANGIOLI, R., OCHIAI, K."COMPARISON OF CYTOTOXICITY AND CELL KINETIC PERTURBATIONS OF 5 PLATINUM COMPOUNDS IN GYNECOLOGIC CANCER CELL-LINES". International Journal of Oncology 3, no. 2 (1993): 375-382. https://doi.org/10.3892/ijo.3.2.375
Copy and paste a formatted citation
x
Spandidos Publications style
NGUYEN H, SEVIN B, AVERETTE H, PERRAS J, RAMOS R, ANGIOLI R and OCHIAI K: COMPARISON OF CYTOTOXICITY AND CELL KINETIC PERTURBATIONS OF 5 PLATINUM COMPOUNDS IN GYNECOLOGIC CANCER CELL-LINES. Int J Oncol 3: 375-382, 1993.
APA
NGUYEN, H., SEVIN, B., AVERETTE, H., PERRAS, J., RAMOS, R., ANGIOLI, R., & OCHIAI, K. (1993). COMPARISON OF CYTOTOXICITY AND CELL KINETIC PERTURBATIONS OF 5 PLATINUM COMPOUNDS IN GYNECOLOGIC CANCER CELL-LINES. International Journal of Oncology, 3, 375-382. https://doi.org/10.3892/ijo.3.2.375
MLA
NGUYEN, H., SEVIN, B., AVERETTE, H., PERRAS, J., RAMOS, R., ANGIOLI, R., OCHIAI, K."COMPARISON OF CYTOTOXICITY AND CELL KINETIC PERTURBATIONS OF 5 PLATINUM COMPOUNDS IN GYNECOLOGIC CANCER CELL-LINES". International Journal of Oncology 3.2 (1993): 375-382.
Chicago
NGUYEN, H., SEVIN, B., AVERETTE, H., PERRAS, J., RAMOS, R., ANGIOLI, R., OCHIAI, K."COMPARISON OF CYTOTOXICITY AND CELL KINETIC PERTURBATIONS OF 5 PLATINUM COMPOUNDS IN GYNECOLOGIC CANCER CELL-LINES". International Journal of Oncology 3, no. 2 (1993): 375-382. https://doi.org/10.3892/ijo.3.2.375
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