8-CHLOROADENOSINE 3',5'-MONOPHOSPHATE AS A NOVEL MODULATOR OF MULTIDRUG-RESISTANCE

  • Authors:
    • H YOKOZAKI
    • A BUDILLON
    • T CLAIR
    • K KELLEY
    • KH COWAN
    • C ROHLFF
    • RI GLAZER
    • YS CHO-CHUNG
  • View Affiliations

  • Published online on: September 1, 1993     https://doi.org/10.3892/ijo.3.3.423
  • Pages: 423-430
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Abstract

Multidrug resistance (MDR) is a major obstacle in the chemotherapy of cancer. 8-chloroadenosine 3',5'-monophosphate (8-Cl-cAMP), a site-selective analog of cAMP, produced a potent growth inhibition in a spectrum of MDR cell lines. The IC50 (concentration inhibiting 50% of cell proliferation) of 8-Cl-cAMP at 6 days ranged from 0.1 to 3.0 muM in both P-glycoprotein (pgp)-associated and pgp-unassociated MDR cells, and the growth inhibition occurred with continued cell viability. Growth inhibition paralleled down-regulation of RIalpha subunit and catalytic activity of cAMP-dependent protein kinase. 8-Cl-cAMP also provoked the suppression of the promoter activity of the MDR1 gene. These results demonstrate that type I cAMP-dependent protein kinase plays a role in drug resistance and that 8-Cl-cAMP is a novel modulator of multidrug resistance.

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September 1993
Volume 3 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
YOKOZAKI H, BUDILLON A, CLAIR T, KELLEY K, COWAN K, ROHLFF C, GLAZER R and CHO-CHUNG Y: 8-CHLOROADENOSINE 3',5'-MONOPHOSPHATE AS A NOVEL MODULATOR OF MULTIDRUG-RESISTANCE. Int J Oncol 3: 423-430, 1993
APA
YOKOZAKI, H., BUDILLON, A., CLAIR, T., KELLEY, K., COWAN, K., ROHLFF, C. ... CHO-CHUNG, Y. (1993). 8-CHLOROADENOSINE 3',5'-MONOPHOSPHATE AS A NOVEL MODULATOR OF MULTIDRUG-RESISTANCE. International Journal of Oncology, 3, 423-430. https://doi.org/10.3892/ijo.3.3.423
MLA
YOKOZAKI, H., BUDILLON, A., CLAIR, T., KELLEY, K., COWAN, K., ROHLFF, C., GLAZER, R., CHO-CHUNG, Y."8-CHLOROADENOSINE 3',5'-MONOPHOSPHATE AS A NOVEL MODULATOR OF MULTIDRUG-RESISTANCE". International Journal of Oncology 3.3 (1993): 423-430.
Chicago
YOKOZAKI, H., BUDILLON, A., CLAIR, T., KELLEY, K., COWAN, K., ROHLFF, C., GLAZER, R., CHO-CHUNG, Y."8-CHLOROADENOSINE 3',5'-MONOPHOSPHATE AS A NOVEL MODULATOR OF MULTIDRUG-RESISTANCE". International Journal of Oncology 3, no. 3 (1993): 423-430. https://doi.org/10.3892/ijo.3.3.423