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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 1993 Volume 3 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 1993 Volume 3 Issue 4

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PROLONGED PROLIFERATION OF PRIMARY CHICKEN-EMBRYO FIBROBLASTS TRANSFECTED WITH CDNAS FROM THE BAMHI-H GENE FAMILY OF MAREKS-DISEASE VIRUS

  • Authors:
    • FY PENG
    • J DONOVAN
    • S SPECTER
    • A TANAKA
    • M NONOYAMA
  • View Affiliations / Copyright

    Affiliations: TAMPA BAY RES INST,VIROL LAB,10900 ROOSEVELT BLVD,ST PETERSBURG,FL 33716. UNIV S FLORIDA,COLL MED,DEPT MED MICROBIOL & IMMUNOL,TAMPA,FL 33612.
  • Pages: 587-591
    |
    Published online on: October 1, 1993
       https://doi.org/10.3892/ijo.3.4.587
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Abstract

Oncogenic virus-specific 1.69 kb and 1.5 kb cDNAs, derived from the tumorigenicity-associated BamHI-H gene family of Marek's disease virus (MDV), were cloned into the eukaryotic expression vector (PRC/CMV) and designated as PRC/CMV-1.69 and PRC/CMV-1.5, respectively. Chicken embryo fibroblasts (CEFs) transfected with PRC/CMV-1.69 or PRC/CMV-1.5 plasmid DNA showed reduced serum-dependence for growth compared with PRC/CMV vector-transfected CEFs. Also, PRC/CMV-1.69 or PRC/CMV-1.5 DNA transfected CEFs proliferated for a longer period of time (20-22 passages) compared with the CEFs transfected with PRC/CMV plasmid DNA (10 passages). Reduced serum-dependence for growth and prolonged proliferation of CEFs after in vitro transfection with PRC/CMV-1.69 or PRC/CMV-1.5 indicated that these two cDNAs stimulate cell growth. These data indicated that one of the functions of the BamHI-H gene family of MDV is cell-growth control, which may play an important role in the establishment and maintenance of uncontrolled growth of tumor cells induced by MDV.

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Copy and paste a formatted citation
Spandidos Publications style
PENG F, DONOVAN J, SPECTER S, TANAKA A and NONOYAMA M: PROLONGED PROLIFERATION OF PRIMARY CHICKEN-EMBRYO FIBROBLASTS TRANSFECTED WITH CDNAS FROM THE BAMHI-H GENE FAMILY OF MAREKS-DISEASE VIRUS. Int J Oncol 3: 587-591, 1993.
APA
PENG, F., DONOVAN, J., SPECTER, S., TANAKA, A., & NONOYAMA, M. (1993). PROLONGED PROLIFERATION OF PRIMARY CHICKEN-EMBRYO FIBROBLASTS TRANSFECTED WITH CDNAS FROM THE BAMHI-H GENE FAMILY OF MAREKS-DISEASE VIRUS. International Journal of Oncology, 3, 587-591. https://doi.org/10.3892/ijo.3.4.587
MLA
PENG, F., DONOVAN, J., SPECTER, S., TANAKA, A., NONOYAMA, M."PROLONGED PROLIFERATION OF PRIMARY CHICKEN-EMBRYO FIBROBLASTS TRANSFECTED WITH CDNAS FROM THE BAMHI-H GENE FAMILY OF MAREKS-DISEASE VIRUS". International Journal of Oncology 3.4 (1993): 587-591.
Chicago
PENG, F., DONOVAN, J., SPECTER, S., TANAKA, A., NONOYAMA, M."PROLONGED PROLIFERATION OF PRIMARY CHICKEN-EMBRYO FIBROBLASTS TRANSFECTED WITH CDNAS FROM THE BAMHI-H GENE FAMILY OF MAREKS-DISEASE VIRUS". International Journal of Oncology 3, no. 4 (1993): 587-591. https://doi.org/10.3892/ijo.3.4.587
Copy and paste a formatted citation
x
Spandidos Publications style
PENG F, DONOVAN J, SPECTER S, TANAKA A and NONOYAMA M: PROLONGED PROLIFERATION OF PRIMARY CHICKEN-EMBRYO FIBROBLASTS TRANSFECTED WITH CDNAS FROM THE BAMHI-H GENE FAMILY OF MAREKS-DISEASE VIRUS. Int J Oncol 3: 587-591, 1993.
APA
PENG, F., DONOVAN, J., SPECTER, S., TANAKA, A., & NONOYAMA, M. (1993). PROLONGED PROLIFERATION OF PRIMARY CHICKEN-EMBRYO FIBROBLASTS TRANSFECTED WITH CDNAS FROM THE BAMHI-H GENE FAMILY OF MAREKS-DISEASE VIRUS. International Journal of Oncology, 3, 587-591. https://doi.org/10.3892/ijo.3.4.587
MLA
PENG, F., DONOVAN, J., SPECTER, S., TANAKA, A., NONOYAMA, M."PROLONGED PROLIFERATION OF PRIMARY CHICKEN-EMBRYO FIBROBLASTS TRANSFECTED WITH CDNAS FROM THE BAMHI-H GENE FAMILY OF MAREKS-DISEASE VIRUS". International Journal of Oncology 3.4 (1993): 587-591.
Chicago
PENG, F., DONOVAN, J., SPECTER, S., TANAKA, A., NONOYAMA, M."PROLONGED PROLIFERATION OF PRIMARY CHICKEN-EMBRYO FIBROBLASTS TRANSFECTED WITH CDNAS FROM THE BAMHI-H GENE FAMILY OF MAREKS-DISEASE VIRUS". International Journal of Oncology 3, no. 4 (1993): 587-591. https://doi.org/10.3892/ijo.3.4.587
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