PROLONGED PROLIFERATION OF PRIMARY CHICKEN-EMBRYO FIBROBLASTS TRANSFECTED WITH CDNAS FROM THE BAMHI-H GENE FAMILY OF MAREKS-DISEASE VIRUS

  • Authors:
    • FY PENG
    • J DONOVAN
    • S SPECTER
    • A TANAKA
    • M NONOYAMA
  • View Affiliations

  • Published online on: October 1, 1993     https://doi.org/10.3892/ijo.3.4.587
  • Pages: 587-591
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Abstract

Oncogenic virus-specific 1.69 kb and 1.5 kb cDNAs, derived from the tumorigenicity-associated BamHI-H gene family of Marek's disease virus (MDV), were cloned into the eukaryotic expression vector (PRC/CMV) and designated as PRC/CMV-1.69 and PRC/CMV-1.5, respectively. Chicken embryo fibroblasts (CEFs) transfected with PRC/CMV-1.69 or PRC/CMV-1.5 plasmid DNA showed reduced serum-dependence for growth compared with PRC/CMV vector-transfected CEFs. Also, PRC/CMV-1.69 or PRC/CMV-1.5 DNA transfected CEFs proliferated for a longer period of time (20-22 passages) compared with the CEFs transfected with PRC/CMV plasmid DNA (10 passages). Reduced serum-dependence for growth and prolonged proliferation of CEFs after in vitro transfection with PRC/CMV-1.69 or PRC/CMV-1.5 indicated that these two cDNAs stimulate cell growth. These data indicated that one of the functions of the BamHI-H gene family of MDV is cell-growth control, which may play an important role in the establishment and maintenance of uncontrolled growth of tumor cells induced by MDV.

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October 1993
Volume 3 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
PENG F, DONOVAN J, SPECTER S, TANAKA A and NONOYAMA M: PROLONGED PROLIFERATION OF PRIMARY CHICKEN-EMBRYO FIBROBLASTS TRANSFECTED WITH CDNAS FROM THE BAMHI-H GENE FAMILY OF MAREKS-DISEASE VIRUS. Int J Oncol 3: 587-591, 1993
APA
PENG, F., DONOVAN, J., SPECTER, S., TANAKA, A., & NONOYAMA, M. (1993). PROLONGED PROLIFERATION OF PRIMARY CHICKEN-EMBRYO FIBROBLASTS TRANSFECTED WITH CDNAS FROM THE BAMHI-H GENE FAMILY OF MAREKS-DISEASE VIRUS. International Journal of Oncology, 3, 587-591. https://doi.org/10.3892/ijo.3.4.587
MLA
PENG, F., DONOVAN, J., SPECTER, S., TANAKA, A., NONOYAMA, M."PROLONGED PROLIFERATION OF PRIMARY CHICKEN-EMBRYO FIBROBLASTS TRANSFECTED WITH CDNAS FROM THE BAMHI-H GENE FAMILY OF MAREKS-DISEASE VIRUS". International Journal of Oncology 3.4 (1993): 587-591.
Chicago
PENG, F., DONOVAN, J., SPECTER, S., TANAKA, A., NONOYAMA, M."PROLONGED PROLIFERATION OF PRIMARY CHICKEN-EMBRYO FIBROBLASTS TRANSFECTED WITH CDNAS FROM THE BAMHI-H GENE FAMILY OF MAREKS-DISEASE VIRUS". International Journal of Oncology 3, no. 4 (1993): 587-591. https://doi.org/10.3892/ijo.3.4.587