MELATONIN MODULATION OF ESTROGEN-RECEPTOR EXPRESSION IN MCF-7 HUMAN BREAST-CANCER CELLS

  • Authors:
    • TM MOLIS
    • MR WALTERS
    • SM HILL
  • View Affiliations

  • Published online on: October 1, 1993     https://doi.org/10.3892/ijo.3.4.687
  • Pages: 687-694
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Abstract

MCF-7 human breast cancer cells, which are estrogen receptor (ER)-positive and responsive to the mitogenic actions of estrogen, were used to examine the possible association between the growth-inhibitory activity of melatonin and its ability to modulate the estrogen-response pathway. Melatonin at physiologic concentrations (10(-8)-10(-11) M) significantly decreased estrogen binding activity and the expression of immunoreactive ER in a dose-specific and time-dependent manner. However, melatonin did not alter receptor affinity and was unable to compete with estrogen for binding to the ER. Studies in a yeast trancriptional assay system confirmed that melatonin does not directly bind to the ER to modulate ER expression. Thus, it appears that the antimitotic actions of melatonin may be mediated, at least in part, through the suppression of the estrogen-response pathway of MCF-7 cells.

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October 1993
Volume 3 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
MOLIS T, WALTERS M and HILL S: MELATONIN MODULATION OF ESTROGEN-RECEPTOR EXPRESSION IN MCF-7 HUMAN BREAST-CANCER CELLS. Int J Oncol 3: 687-694, 1993
APA
MOLIS, T., WALTERS, M., & HILL, S. (1993). MELATONIN MODULATION OF ESTROGEN-RECEPTOR EXPRESSION IN MCF-7 HUMAN BREAST-CANCER CELLS. International Journal of Oncology, 3, 687-694. https://doi.org/10.3892/ijo.3.4.687
MLA
MOLIS, T., WALTERS, M., HILL, S."MELATONIN MODULATION OF ESTROGEN-RECEPTOR EXPRESSION IN MCF-7 HUMAN BREAST-CANCER CELLS". International Journal of Oncology 3.4 (1993): 687-694.
Chicago
MOLIS, T., WALTERS, M., HILL, S."MELATONIN MODULATION OF ESTROGEN-RECEPTOR EXPRESSION IN MCF-7 HUMAN BREAST-CANCER CELLS". International Journal of Oncology 3, no. 4 (1993): 687-694. https://doi.org/10.3892/ijo.3.4.687