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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 1993 Volume 3 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 1993 Volume 3 Issue 4

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Article

ABSENCE OF GERMLINE PROHIBITIN MUTATIONS IN EARLY-ONSET BREAST-CANCER

  • Authors:
    • T TOKINO
    • N DAVIDSON
    • K HELZLSOUER
    • B ZEHNBAUER
    • Y NAKAMURA
    • B VOGELSTEIN
    • D SIDRANSKY

  • View Affiliations / Copyright

    Affiliations: JOHNS HOPKINS UNIV,DIV HEAD & NECK CANC RES,BALTIMORE,MD 21203. JOHNS HOPKINS UNIV,CTR ONCOL,BALTIMORE,MD 21218. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,BALTIMORE,MD 21218. JAPANESE FDN CANC RES,INST CANC,DEPT BIOCHEM,TOKYO 170,JAPAN.
  • Pages: 769-772
    |
    Published online on: October 1, 1993
       https://doi.org/10.3892/ijo.3.4.769
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Abstract

The prohibitin gene, mapped to chromosome 17q21 is a candidate tumor suppressor gene. Because several somatic mutations of prohibitin were detected in breast tumors, we sought to identify potential carriers of prohibitin gene mutations in selected patients with early onset breast cancer. Seventy-six patients who developed breast cancer at or before the age of 40 were examined for mutations of prohibitin within the most conserved regions of the gene. Additionally, all exons of the prohibitin gene were examined in a subgroup of patients with a history of first-degree relatives with primary breast cancer. While several polymorphisms were noted, no inherited mutations of prohibitin were identified. This study suggests that prohibitin is not an early onset breast cancer susceptibility gene and additional studies will be necessary to understand its role in sporadic breast cancer progression.

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Copy and paste a formatted citation
Spandidos Publications style
TOKINO T, DAVIDSON N, HELZLSOUER K, ZEHNBAUER B, NAKAMURA Y, VOGELSTEIN B and SIDRANSKY D: ABSENCE OF GERMLINE PROHIBITIN MUTATIONS IN EARLY-ONSET BREAST-CANCER. Int J Oncol 3: 769-772, 1993.
APA
TOKINO, T., DAVIDSON, N., HELZLSOUER, K., ZEHNBAUER, B., NAKAMURA, Y., VOGELSTEIN, B., & SIDRANSKY, D. (1993). ABSENCE OF GERMLINE PROHIBITIN MUTATIONS IN EARLY-ONSET BREAST-CANCER. International Journal of Oncology, 3, 769-772. https://doi.org/10.3892/ijo.3.4.769
MLA
TOKINO, T., DAVIDSON, N., HELZLSOUER, K., ZEHNBAUER, B., NAKAMURA, Y., VOGELSTEIN, B., SIDRANSKY, D."ABSENCE OF GERMLINE PROHIBITIN MUTATIONS IN EARLY-ONSET BREAST-CANCER". International Journal of Oncology 3.4 (1993): 769-772.
Chicago
TOKINO, T., DAVIDSON, N., HELZLSOUER, K., ZEHNBAUER, B., NAKAMURA, Y., VOGELSTEIN, B., SIDRANSKY, D."ABSENCE OF GERMLINE PROHIBITIN MUTATIONS IN EARLY-ONSET BREAST-CANCER". International Journal of Oncology 3, no. 4 (1993): 769-772. https://doi.org/10.3892/ijo.3.4.769
Copy and paste a formatted citation
x
Spandidos Publications style
TOKINO T, DAVIDSON N, HELZLSOUER K, ZEHNBAUER B, NAKAMURA Y, VOGELSTEIN B and SIDRANSKY D: ABSENCE OF GERMLINE PROHIBITIN MUTATIONS IN EARLY-ONSET BREAST-CANCER. Int J Oncol 3: 769-772, 1993.
APA
TOKINO, T., DAVIDSON, N., HELZLSOUER, K., ZEHNBAUER, B., NAKAMURA, Y., VOGELSTEIN, B., & SIDRANSKY, D. (1993). ABSENCE OF GERMLINE PROHIBITIN MUTATIONS IN EARLY-ONSET BREAST-CANCER. International Journal of Oncology, 3, 769-772. https://doi.org/10.3892/ijo.3.4.769
MLA
TOKINO, T., DAVIDSON, N., HELZLSOUER, K., ZEHNBAUER, B., NAKAMURA, Y., VOGELSTEIN, B., SIDRANSKY, D."ABSENCE OF GERMLINE PROHIBITIN MUTATIONS IN EARLY-ONSET BREAST-CANCER". International Journal of Oncology 3.4 (1993): 769-772.
Chicago
TOKINO, T., DAVIDSON, N., HELZLSOUER, K., ZEHNBAUER, B., NAKAMURA, Y., VOGELSTEIN, B., SIDRANSKY, D."ABSENCE OF GERMLINE PROHIBITIN MUTATIONS IN EARLY-ONSET BREAST-CANCER". International Journal of Oncology 3, no. 4 (1993): 769-772. https://doi.org/10.3892/ijo.3.4.769
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