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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 1993 Volume 3 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1993 Volume 3 Issue 5

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Article

CYTOGENETIC STUDIES ON THE IN-VITRO GENOTOXICITY OF 4-NITROQUINOLINE-1-OXIDE ON HUMAN-LYMPHOCYTES

  • Authors:
    • TC HSU
    • N SAVARAJI
    • Z TRIZNA
    • L FEUN
    • C FURLONG
    • SP SCHANTZ
    • L SHIRLEY

  • View Affiliations / Copyright

    Affiliations: UNIV MIAMI,SCH MED,DEPT ONCOL,MIAMI,FL 33152. UNIV TEXAS,MD ANDERSON CANC CTR,DEPT HEAD & NECK SURG,HOUSTON,TX 77030. UNIV MIAMI,SYLVESTER COMPREHENS CANC CTR,DEPT MED,MIAMI,FL 33152. MEM SLOAN KETTERING CANC CTR,DEPT HEAD & NECK SURG,NEW YORK,NY 10021.
  • Pages: 823-826
    |
    Published online on: November 1, 1993
       https://doi.org/10.3892/ijo.3.5.823
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Abstract

Using the UV-mimetic mutagen 4-nitroquinoline-1-oxide (4NQO) to induce genetic damage in human cells (lymphoblastoid lines and primary cultures of peripheral blood samples), chromosome aberrations were induced by treating the cells with 4NQO at 1 X 10(-5) M for 24 h. The overwhelming majority of chromosome aberrations was of the chromatid (S + G2) type instead of the chromosome (G1) type. The most common chromatid aberrations were simple breaks, isochromatid breaks, and chromatid exchanges. When the number of chromatid breaks per cell value was used as a measurement for 4NQO sensitivity, lymphoblastoid cells from a xeroderma pigmentosum patient showed the highest sensitivity, followed by the cells of two melanoma patients and normal persons. These preliminary results suggest that 4NQO may be employed to develop an assay system as a biomarker for determining UV sensitivity in the human population.

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Copy and paste a formatted citation
Spandidos Publications style
HSU T, SAVARAJI N, TRIZNA Z, FEUN L, FURLONG C, SCHANTZ S and SHIRLEY L: CYTOGENETIC STUDIES ON THE IN-VITRO GENOTOXICITY OF 4-NITROQUINOLINE-1-OXIDE ON HUMAN-LYMPHOCYTES. Int J Oncol 3: 823-826, 1993.
APA
HSU, T., SAVARAJI, N., TRIZNA, Z., FEUN, L., FURLONG, C., SCHANTZ, S., & SHIRLEY, L. (1993). CYTOGENETIC STUDIES ON THE IN-VITRO GENOTOXICITY OF 4-NITROQUINOLINE-1-OXIDE ON HUMAN-LYMPHOCYTES. International Journal of Oncology, 3, 823-826. https://doi.org/10.3892/ijo.3.5.823
MLA
HSU, T., SAVARAJI, N., TRIZNA, Z., FEUN, L., FURLONG, C., SCHANTZ, S., SHIRLEY, L."CYTOGENETIC STUDIES ON THE IN-VITRO GENOTOXICITY OF 4-NITROQUINOLINE-1-OXIDE ON HUMAN-LYMPHOCYTES". International Journal of Oncology 3.5 (1993): 823-826.
Chicago
HSU, T., SAVARAJI, N., TRIZNA, Z., FEUN, L., FURLONG, C., SCHANTZ, S., SHIRLEY, L."CYTOGENETIC STUDIES ON THE IN-VITRO GENOTOXICITY OF 4-NITROQUINOLINE-1-OXIDE ON HUMAN-LYMPHOCYTES". International Journal of Oncology 3, no. 5 (1993): 823-826. https://doi.org/10.3892/ijo.3.5.823
Copy and paste a formatted citation
x
Spandidos Publications style
HSU T, SAVARAJI N, TRIZNA Z, FEUN L, FURLONG C, SCHANTZ S and SHIRLEY L: CYTOGENETIC STUDIES ON THE IN-VITRO GENOTOXICITY OF 4-NITROQUINOLINE-1-OXIDE ON HUMAN-LYMPHOCYTES. Int J Oncol 3: 823-826, 1993.
APA
HSU, T., SAVARAJI, N., TRIZNA, Z., FEUN, L., FURLONG, C., SCHANTZ, S., & SHIRLEY, L. (1993). CYTOGENETIC STUDIES ON THE IN-VITRO GENOTOXICITY OF 4-NITROQUINOLINE-1-OXIDE ON HUMAN-LYMPHOCYTES. International Journal of Oncology, 3, 823-826. https://doi.org/10.3892/ijo.3.5.823
MLA
HSU, T., SAVARAJI, N., TRIZNA, Z., FEUN, L., FURLONG, C., SCHANTZ, S., SHIRLEY, L."CYTOGENETIC STUDIES ON THE IN-VITRO GENOTOXICITY OF 4-NITROQUINOLINE-1-OXIDE ON HUMAN-LYMPHOCYTES". International Journal of Oncology 3.5 (1993): 823-826.
Chicago
HSU, T., SAVARAJI, N., TRIZNA, Z., FEUN, L., FURLONG, C., SCHANTZ, S., SHIRLEY, L."CYTOGENETIC STUDIES ON THE IN-VITRO GENOTOXICITY OF 4-NITROQUINOLINE-1-OXIDE ON HUMAN-LYMPHOCYTES". International Journal of Oncology 3, no. 5 (1993): 823-826. https://doi.org/10.3892/ijo.3.5.823
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