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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 1993 Volume 3 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1993 Volume 3 Issue 5

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Article

DIFFERENTIAL SENSITIVITY AMONG 3 HUMAN SUBPOPULATIONS IN RESPONSE TO 4-NITROQUINOLINE-1-OXIDE AND TO BLEOMYCIN

  • Authors:
    • TC HSU
    • L FEUN
    • Z TRIZNA
    • N SAVARAJ
    • LR SHIRLEY
    • CL FURLONG
    • SP SCHANTZ
    • RS WEBER
    • TJ SHEN
    • O KUCUK

  • View Affiliations / Copyright

    Affiliations: CANC RES CTR HAWAII,HONOLULU,HI. UNIV MIAMI,SCH MED,DEPT ONCOL,MIAMI,FL 33152. MEM SLOAN KETTERING CANC CTR,DEPT HEAD & NECK SURG,NEW YORK,NY 10021. UNIV MIAMI,SYLVESTER COMPREHENS CANC CTR,DEPT MED,MIAMI,FL 33152. UNIV TEXAS,MD ANDERSON CANC CTR,DEPT HEAD & NECK SURG,HOUSTON,TX 77030.
  • Pages: 827-830
    |
    Published online on: November 1, 1993
       https://doi.org/10.3892/ijo.3.5.827
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Abstract

An assay employing the UV-mimetic mutagen 4-nitroquinoline-1-oxide (4NQO) to estimate a person's UV-sensitivity was developed. This sensitivity may be translated into an individual's susceptibility to acquire cutaneous malignancies. We used cytogenetic recordings on cultured lymphocytes from 103 normal individuals, 62 melanoma patients, and 71 patients with head and neck cancer. The frequency of chromosome damage (chromatid breaks) caused by exposure to 4NQO was used to measure sensitivity. Preliminary results showed that a significantly higher proportion of melanoma patients was 4NQO sensitive compared to the other two groups, whose 4NQO sensitivity was statistically not different. Although a number of theoretical and technical problems remain to be resolved and a great deal of additional information (especially clinical and epidemiological) is needed, it appears that 4NQO sensitivity may be effectively employed as a biological marker for identification of individuals at risk for melanoma (and possibly other cutaneous neoplasms as well).

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Copy and paste a formatted citation
Spandidos Publications style
HSU T, FEUN L, TRIZNA Z, SAVARAJ N, SHIRLEY L, FURLONG C, SCHANTZ S, WEBER R, SHEN T, KUCUK O, KUCUK O, et al: DIFFERENTIAL SENSITIVITY AMONG 3 HUMAN SUBPOPULATIONS IN RESPONSE TO 4-NITROQUINOLINE-1-OXIDE AND TO BLEOMYCIN. Int J Oncol 3: 827-830, 1993.
APA
HSU, T., FEUN, L., TRIZNA, Z., SAVARAJ, N., SHIRLEY, L., FURLONG, C. ... KUCUK, O. (1993). DIFFERENTIAL SENSITIVITY AMONG 3 HUMAN SUBPOPULATIONS IN RESPONSE TO 4-NITROQUINOLINE-1-OXIDE AND TO BLEOMYCIN. International Journal of Oncology, 3, 827-830. https://doi.org/10.3892/ijo.3.5.827
MLA
HSU, T., FEUN, L., TRIZNA, Z., SAVARAJ, N., SHIRLEY, L., FURLONG, C., SCHANTZ, S., WEBER, R., SHEN, T., KUCUK, O."DIFFERENTIAL SENSITIVITY AMONG 3 HUMAN SUBPOPULATIONS IN RESPONSE TO 4-NITROQUINOLINE-1-OXIDE AND TO BLEOMYCIN". International Journal of Oncology 3.5 (1993): 827-830.
Chicago
HSU, T., FEUN, L., TRIZNA, Z., SAVARAJ, N., SHIRLEY, L., FURLONG, C., SCHANTZ, S., WEBER, R., SHEN, T., KUCUK, O."DIFFERENTIAL SENSITIVITY AMONG 3 HUMAN SUBPOPULATIONS IN RESPONSE TO 4-NITROQUINOLINE-1-OXIDE AND TO BLEOMYCIN". International Journal of Oncology 3, no. 5 (1993): 827-830. https://doi.org/10.3892/ijo.3.5.827
Copy and paste a formatted citation
x
Spandidos Publications style
HSU T, FEUN L, TRIZNA Z, SAVARAJ N, SHIRLEY L, FURLONG C, SCHANTZ S, WEBER R, SHEN T, KUCUK O, KUCUK O, et al: DIFFERENTIAL SENSITIVITY AMONG 3 HUMAN SUBPOPULATIONS IN RESPONSE TO 4-NITROQUINOLINE-1-OXIDE AND TO BLEOMYCIN. Int J Oncol 3: 827-830, 1993.
APA
HSU, T., FEUN, L., TRIZNA, Z., SAVARAJ, N., SHIRLEY, L., FURLONG, C. ... KUCUK, O. (1993). DIFFERENTIAL SENSITIVITY AMONG 3 HUMAN SUBPOPULATIONS IN RESPONSE TO 4-NITROQUINOLINE-1-OXIDE AND TO BLEOMYCIN. International Journal of Oncology, 3, 827-830. https://doi.org/10.3892/ijo.3.5.827
MLA
HSU, T., FEUN, L., TRIZNA, Z., SAVARAJ, N., SHIRLEY, L., FURLONG, C., SCHANTZ, S., WEBER, R., SHEN, T., KUCUK, O."DIFFERENTIAL SENSITIVITY AMONG 3 HUMAN SUBPOPULATIONS IN RESPONSE TO 4-NITROQUINOLINE-1-OXIDE AND TO BLEOMYCIN". International Journal of Oncology 3.5 (1993): 827-830.
Chicago
HSU, T., FEUN, L., TRIZNA, Z., SAVARAJ, N., SHIRLEY, L., FURLONG, C., SCHANTZ, S., WEBER, R., SHEN, T., KUCUK, O."DIFFERENTIAL SENSITIVITY AMONG 3 HUMAN SUBPOPULATIONS IN RESPONSE TO 4-NITROQUINOLINE-1-OXIDE AND TO BLEOMYCIN". International Journal of Oncology 3, no. 5 (1993): 827-830. https://doi.org/10.3892/ijo.3.5.827
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