EXPRESSION OF GLUTATHIONE-S-TRANSFERASE (GST) SUBTYPES IN RESECTED LUNG-TUMORS - RELATIONSHIP TO HISTOLOGICAL TYPE AND PROLIFERATION INDEXES
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- Published online on: November 1, 1993 https://doi.org/10.3892/ijo.3.5.881
- Pages: 881-886
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Abstract
Samples from 19 resected lung tumours have been analysed for the levels of GST alpha, mu and pi mRNA and protein. No significant survival disadvantage was found for patients with tumours containing any of the GST subtypes at the levels of either protein or mRNA. Both GST mu and GST pi mRNAs were expressed at significantly higher levels in squamous carcinomas than adenocarcinomas but GST alpha mRNA was not. The significant increases in expression of mu and pi GST in squamous relative to adenocarcinomas of the lung is not related to differences in the proliferation rates between these cancers.
