EXPRESSION OF GLUTATHIONE-S-TRANSFERASE (GST) SUBTYPES IN RESECTED LUNG-TUMORS - RELATIONSHIP TO HISTOLOGICAL TYPE AND PROLIFERATION INDEXES

  • Authors:
    • T HATTON
    • N PENDLETON
    • R BARRACLOUGH
    • JA GREEN
  • View Affiliations

  • Published online on: November 1, 1993     https://doi.org/10.3892/ijo.3.5.881
  • Pages: 881-886
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Samples from 19 resected lung tumours have been analysed for the levels of GST alpha, mu and pi mRNA and protein. No significant survival disadvantage was found for patients with tumours containing any of the GST subtypes at the levels of either protein or mRNA. Both GST mu and GST pi mRNAs were expressed at significantly higher levels in squamous carcinomas than adenocarcinomas but GST alpha mRNA was not. The significant increases in expression of mu and pi GST in squamous relative to adenocarcinomas of the lung is not related to differences in the proliferation rates between these cancers.

Related Articles

Journal Cover

November 1993
Volume 3 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
HATTON T, PENDLETON N, BARRACLOUGH R and GREEN J: EXPRESSION OF GLUTATHIONE-S-TRANSFERASE (GST) SUBTYPES IN RESECTED LUNG-TUMORS - RELATIONSHIP TO HISTOLOGICAL TYPE AND PROLIFERATION INDEXES. Int J Oncol 3: 881-886, 1993.
APA
HATTON, T., PENDLETON, N., BARRACLOUGH, R., & GREEN, J. (1993). EXPRESSION OF GLUTATHIONE-S-TRANSFERASE (GST) SUBTYPES IN RESECTED LUNG-TUMORS - RELATIONSHIP TO HISTOLOGICAL TYPE AND PROLIFERATION INDEXES. International Journal of Oncology, 3, 881-886. https://doi.org/10.3892/ijo.3.5.881
MLA
HATTON, T., PENDLETON, N., BARRACLOUGH, R., GREEN, J."EXPRESSION OF GLUTATHIONE-S-TRANSFERASE (GST) SUBTYPES IN RESECTED LUNG-TUMORS - RELATIONSHIP TO HISTOLOGICAL TYPE AND PROLIFERATION INDEXES". International Journal of Oncology 3.5 (1993): 881-886.
Chicago
HATTON, T., PENDLETON, N., BARRACLOUGH, R., GREEN, J."EXPRESSION OF GLUTATHIONE-S-TRANSFERASE (GST) SUBTYPES IN RESECTED LUNG-TUMORS - RELATIONSHIP TO HISTOLOGICAL TYPE AND PROLIFERATION INDEXES". International Journal of Oncology 3, no. 5 (1993): 881-886. https://doi.org/10.3892/ijo.3.5.881