RESULTS OF THE ASSOCIATION OF INTRALESIONAL RECOMBINANT ALPHA-INTERFERON-2A (ALPHA-IFN) PLUS 13-CIS-RETINOIC ACID (13CRA) IN THE TREATMENT OF BASAL-CELL CARCINOMAS (BCC) OF THE SKIN

TOMA,S; VINCENTI,M; PALUMBO,R; MUZIO,G; RAINERO,ML; SANTI,P; ROSSO,R

doi:10.3892/ijo.3.6.1149

December 1993 Volume 3 Issue 6

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December 1993 Volume 3 Issue 6

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Article

RESULTS OF THE ASSOCIATION OF INTRALESIONAL RECOMBINANT ALPHA-INTERFERON-2A (ALPHA-IFN) PLUS 13-CIS-RETINOIC ACID (13CRA) IN THE TREATMENT OF BASAL-CELL CARCINOMAS (BCC) OF THE SKIN

Authors:
- S TOMA
- M VINCENTI
- R PALUMBO
- G MUZIO
- ML RAINERO
- P SANTI
- R ROSSO
View Affiliations / Copyright

Affiliations: UNIV GENOA,INST ONCOL,I-16132 GENOA,ITALY. UNIV GENOA,DERMATOL CLIN,I-16132 GENOA,ITALY.
Pages: 1149-1154
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Published online on: December 1, 1993

https://doi.org/10.3892/ijo.3.6.1149
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Abstract

In this phase II study, twenty-four patients (median age 72 years) with BCC of the skin were treated with intralesional alpha-IFN plus 13cRA. Alpha-IFN was administered intralesionally at the dose of 3x10(6) I.U. for injection, 3 times/week for 4 weeks (total dose 12x10(6) I.U./cycle); concomitantly, 13cRA was given per os at a 0.2-0.4 mg/kg/day dose. The 4-week cycles were repeated after a one week interval, in which only 13cRA was administered. Patients were evaluated after at least 2 cycles of treatment. Sixteen of the 20 assessable patients (80%) showed an objective response (OR), 12 of whom (60%) had a complete response (CR). The overall OR rate was 75% (12/16) in patients treated with 0.2 mg/kg/day of 13cRA, and 100% (4/4) in patients who received 0.4 mg/kg/day of the drug. The median response duration was 12 months (range, 6 to 20). Toxicity was mild and reversible in all cases; major side effects observed were fever, nausea, skin erythema, hypertriglyceridemia and hypercholesteremia. These results show the efficacy and the feasibility of alpha-IFN and 13cRA acid association in BCC treatment, with good compliance even in elderly patients; this medical approach could be a valid choice of therapy in addition to the traditional surgical modalities, as it also produces satisfactory aesthetical results.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

RESULTS OF THE ASSOCIATION OF INTRALESIONAL RECOMBINANT ALPHA-INTERFERON-2A (ALPHA-IFN) PLUS 13-CIS-RETINOIC ACID (13CRA) IN THE TREATMENT OF BASAL-CELL CARCINOMAS (BCC) OF THE SKIN

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