Integrin-linked kinase: A hypoxia-induced anti-apoptotic factor exploited by cancer cells

  • Authors:
    • Elizabeth R. Abboud
    • Seth B. Coffelt
    • Yanira G. Figueroa
    • Kevin J. Zwezdaryk
    • Anne B. Nelson
    • Deborah E. Sullivan
    • Cindy B. Morris
    • Yan Tang
    • Barbara S. Beckman
    • Aline B. Scandurro
  • View Affiliations

  • Published online on: January 1, 2007     https://doi.org/10.3892/ijo.30.1.113
  • Pages:113-122
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Abstract

Based on cDNA microarray results, integrin-linked kinase (ILK) emerged as an interesting candidate in hypoxia-mediated survival mechanisms employed by cancer cells. This notion was confirmed here by the following observations: the 5' promoter region of the ilk gene contains hypoxia responsive elements (HRE) that bind hypoxia-inducible factor (HIF) transcription factor complexes and drive HRE-luciferase gene expression in reporter assays; ILK protein and kinase activity are induced following hypoxia; downstream targets of ILK signaling are induced following hypoxia treatment; inhibition of ILK leads to increased apoptosis; and HIF and ILK are co-localized within human cancer tissues. The identification of ILK as a player in hypoxia survival signaling employed by cancer cells further validates ILK as a unique target for cancer therapy.

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January 2007
Volume 30 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

2016 Impact Factor: 3.079
Ranked #33/217 Oncology
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APA
Abboud, E.R., Coffelt, S.B., Figueroa, Y.G., Zwezdaryk, K.J., Nelson, A.B., Sullivan, D.E. ... Scandurro, A.B. (2007). Integrin-linked kinase: A hypoxia-induced anti-apoptotic factor exploited by cancer cells. International Journal of Oncology, 30, 113-122. https://doi.org/10.3892/ijo.30.1.113
MLA
Abboud, E. R., Coffelt, S. B., Figueroa, Y. G., Zwezdaryk, K. J., Nelson, A. B., Sullivan, D. E., Morris, C. B., Tang, Y., Beckman, B. S., Scandurro, A. B."Integrin-linked kinase: A hypoxia-induced anti-apoptotic factor exploited by cancer cells". International Journal of Oncology 30.1 (2007): 113-122.
Chicago
Abboud, E. R., Coffelt, S. B., Figueroa, Y. G., Zwezdaryk, K. J., Nelson, A. B., Sullivan, D. E., Morris, C. B., Tang, Y., Beckman, B. S., Scandurro, A. B."Integrin-linked kinase: A hypoxia-induced anti-apoptotic factor exploited by cancer cells". International Journal of Oncology 30, no. 1 (2007): 113-122. https://doi.org/10.3892/ijo.30.1.113