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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2007 Volume 30 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2007 Volume 30 Issue 2

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Article

Marked suppression of tumor growth by FTY720 in a rat liver tumor model: The significance of down-regulation of cell survival Akt pathway

  • Authors:
    • Kevin T. Ng
    • Kwan Man
    • Joanna W. Ho
    • Chris K. Sun
    • Terence K. Lee
    • Yi Zhao
    • Chung Mau Lo
    • Ronnie T. Poon
    • Sheung Tat Fan

  • View Affiliations / Copyright

    Affiliations: Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, P.R. China
  • Pages: 375-380
    |
    Published online on: February 1, 2007
       https://doi.org/10.3892/ijo.30.2.375
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Abstract

We aim to investigate the anticancer effect of a novel immunomodulator FTY720 on a rat orthotopic liver tumor model. A buffalo rat orthotopic liver tumor model was established by injection of a buffalo hepatoma cell line MH7777 into the right portal vein. FTY720 was administered by intraperitoneal injection starting at 10 days after tumor cell injection at a dosage of 5 mg/kg/day. FTY720 markedly suppressed tumor growth and inhibited tumor progression by selective induction of apoptosis of tumor cells via down-regulation of phospho-Aktser473 and up-regulation of cleaved caspase-3, together with decrease of focal adhesion kinase. Moreover, the proliferation index of tumor cells was significantly reduced to 15.92±5.03% by FTY720 compared with that of 42.92±4.47% in the control group (p<0.001). In addition, we confirmed that FTY720 caused no effect on infiltrated lymphocyte in tumor tissue. We conclude that FTY720 is an effective anticancer agent for liver tumor in a rat model without affecting the immune system of the host.

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Copy and paste a formatted citation
Spandidos Publications style
Ng KT, Man K, Ho JW, Sun CK, Lee TK, Zhao Y, Lo CM, Poon RT and Fan ST: Marked suppression of tumor growth by FTY720 in a rat liver tumor model: The significance of down-regulation of cell survival Akt pathway. Int J Oncol 30: 375-380, 2007.
APA
Ng, K.T., Man, K., Ho, J.W., Sun, C.K., Lee, T.K., Zhao, Y. ... Fan, S.T. (2007). Marked suppression of tumor growth by FTY720 in a rat liver tumor model: The significance of down-regulation of cell survival Akt pathway. International Journal of Oncology, 30, 375-380. https://doi.org/10.3892/ijo.30.2.375
MLA
Ng, K. T., Man, K., Ho, J. W., Sun, C. K., Lee, T. K., Zhao, Y., Lo, C. M., Poon, R. T., Fan, S. T."Marked suppression of tumor growth by FTY720 in a rat liver tumor model: The significance of down-regulation of cell survival Akt pathway". International Journal of Oncology 30.2 (2007): 375-380.
Chicago
Ng, K. T., Man, K., Ho, J. W., Sun, C. K., Lee, T. K., Zhao, Y., Lo, C. M., Poon, R. T., Fan, S. T."Marked suppression of tumor growth by FTY720 in a rat liver tumor model: The significance of down-regulation of cell survival Akt pathway". International Journal of Oncology 30, no. 2 (2007): 375-380. https://doi.org/10.3892/ijo.30.2.375
Copy and paste a formatted citation
x
Spandidos Publications style
Ng KT, Man K, Ho JW, Sun CK, Lee TK, Zhao Y, Lo CM, Poon RT and Fan ST: Marked suppression of tumor growth by FTY720 in a rat liver tumor model: The significance of down-regulation of cell survival Akt pathway. Int J Oncol 30: 375-380, 2007.
APA
Ng, K.T., Man, K., Ho, J.W., Sun, C.K., Lee, T.K., Zhao, Y. ... Fan, S.T. (2007). Marked suppression of tumor growth by FTY720 in a rat liver tumor model: The significance of down-regulation of cell survival Akt pathway. International Journal of Oncology, 30, 375-380. https://doi.org/10.3892/ijo.30.2.375
MLA
Ng, K. T., Man, K., Ho, J. W., Sun, C. K., Lee, T. K., Zhao, Y., Lo, C. M., Poon, R. T., Fan, S. T."Marked suppression of tumor growth by FTY720 in a rat liver tumor model: The significance of down-regulation of cell survival Akt pathway". International Journal of Oncology 30.2 (2007): 375-380.
Chicago
Ng, K. T., Man, K., Ho, J. W., Sun, C. K., Lee, T. K., Zhao, Y., Lo, C. M., Poon, R. T., Fan, S. T."Marked suppression of tumor growth by FTY720 in a rat liver tumor model: The significance of down-regulation of cell survival Akt pathway". International Journal of Oncology 30, no. 2 (2007): 375-380. https://doi.org/10.3892/ijo.30.2.375
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