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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2007 Volume 30 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2007 Volume 30 Issue 2

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Article

STI571 sensitizes nasopharyngeal carcinoma cells to cisplatin: Sustained activation of ERK with improved growth inhibition

  • Authors:
    • Lai-Fa Sheu
    • Zuei-How Young
    • Wen-Cheng Lee
    • Yu-Fang Chen
    • Woei-Yau Kao
    • Ann Chen

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Tri-Service General Hospital, Taipei 114, Taiwan, R.O.C. laifakimo@yahoo.com.tw
  • Pages: 403-411
    |
    Published online on: February 1, 2007
       https://doi.org/10.3892/ijo.30.2.403
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Abstract

Previously, we demonstrated that c-kit and stem cell factors (SCF) commonly co-expressed in primary and metastatic nasophayngeal carcinomas (NPC), and in HONE-1 NPC cells with tyrosine autophosphorylation of c-kit. These findings suggest that the SCF/c-kit signaling may contribute to pathogenesis of NPC. Therefore, the efficacy of STI571 treatment alone and when combined with cisplatin on HONE-1 cells were evaluated. STI571 induced growth inhibition at the IC50 concentration (14.9 µM). When the concentration was at or higher than 30 µM, the induction of cell apoptosis was observed. The effects of STI571 were shown to be mediated by the sustained activation of ERK but did not involve the inhibition of c-kit signal activity. When the STI571 (5 µM) and cisplatin (5 µg/ml) treatments were combined, there were further inductions of ERK activation resulting in obviously enhanced growth inhibition and induction of cell apoptosis. In a xenograft model, STI571 (50 mg/kg/day) showed only a limited ability to inhibit HONE-1 cell growth, but when combined with cisplatin (3 mg/kg/twice a week) treatment, there was a significant improvement in growth inhibition compared with STI571 or cisplatin treatment alone. Our results provide experimental support for the advanced NPC therapeutic trials using the combined STI571 and cisplatin treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Sheu L, Young Z, Lee W, Chen Y, Kao W and Chen A: STI571 sensitizes nasopharyngeal carcinoma cells to cisplatin: Sustained activation of ERK with improved growth inhibition. Int J Oncol 30: 403-411, 2007.
APA
Sheu, L., Young, Z., Lee, W., Chen, Y., Kao, W., & Chen, A. (2007). STI571 sensitizes nasopharyngeal carcinoma cells to cisplatin: Sustained activation of ERK with improved growth inhibition. International Journal of Oncology, 30, 403-411. https://doi.org/10.3892/ijo.30.2.403
MLA
Sheu, L., Young, Z., Lee, W., Chen, Y., Kao, W., Chen, A."STI571 sensitizes nasopharyngeal carcinoma cells to cisplatin: Sustained activation of ERK with improved growth inhibition". International Journal of Oncology 30.2 (2007): 403-411.
Chicago
Sheu, L., Young, Z., Lee, W., Chen, Y., Kao, W., Chen, A."STI571 sensitizes nasopharyngeal carcinoma cells to cisplatin: Sustained activation of ERK with improved growth inhibition". International Journal of Oncology 30, no. 2 (2007): 403-411. https://doi.org/10.3892/ijo.30.2.403
Copy and paste a formatted citation
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Spandidos Publications style
Sheu L, Young Z, Lee W, Chen Y, Kao W and Chen A: STI571 sensitizes nasopharyngeal carcinoma cells to cisplatin: Sustained activation of ERK with improved growth inhibition. Int J Oncol 30: 403-411, 2007.
APA
Sheu, L., Young, Z., Lee, W., Chen, Y., Kao, W., & Chen, A. (2007). STI571 sensitizes nasopharyngeal carcinoma cells to cisplatin: Sustained activation of ERK with improved growth inhibition. International Journal of Oncology, 30, 403-411. https://doi.org/10.3892/ijo.30.2.403
MLA
Sheu, L., Young, Z., Lee, W., Chen, Y., Kao, W., Chen, A."STI571 sensitizes nasopharyngeal carcinoma cells to cisplatin: Sustained activation of ERK with improved growth inhibition". International Journal of Oncology 30.2 (2007): 403-411.
Chicago
Sheu, L., Young, Z., Lee, W., Chen, Y., Kao, W., Chen, A."STI571 sensitizes nasopharyngeal carcinoma cells to cisplatin: Sustained activation of ERK with improved growth inhibition". International Journal of Oncology 30, no. 2 (2007): 403-411. https://doi.org/10.3892/ijo.30.2.403
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