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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2007 Volume 30 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2007 Volume 30 Issue 2

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Article

Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral immune system

  • Authors:
    • Hisamitsu Ishikura
    • Hiroaki Ikeda
    • Hiroyuki Abe
    • Takayuki Ohkuri
    • Hiroaki Hiraga
    • Kazuo Isu
    • Tomohide Tsukahara
    • Noriyuki Sato
    • Hidemitsu Kitamura
    • Norimasa Iwasaki
    • Naoki Takeda
    • Akio Minami
    • Takashi Nishimura

  • View Affiliations / Copyright

    Affiliations: Division of Immunoregulation, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan
  • Pages: 461-467
    |
    Published online on: February 1, 2007
       https://doi.org/10.3892/ijo.30.2.461
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Abstract

Since the prognosis of human osteosarcoma in advanced stage remains poor, the development of new and effective therapies including immunotherapy is required. To identify tumor-associated antigens of osteosarcoma applicable to the immunotherapy of this malignancy, we employed the serological analysis of recombinant cDNA expression library (SEREX) technique that defines tumor antigens recognized by the humoral immune system. Screening a cDNA library derived from an osteosarcoma cell line MG63 with sera from osteosarcoma patients identified 43 positive clones, representing 14 distinct antigens. Among them, CLUAP1 (clusterin-associated protein 1) was highly expressed in osteosarcoma tissue samples and cell lines. Overexpression of CLUAP1 was observed in other malignancies including ovarian, colon, and lung cancers. Our results suggest that CLUAP1 may be useful as a prognostic/diagnostic marker and/or for a target of immunotherapy of osteosarcoma.

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Copy and paste a formatted citation
Spandidos Publications style
Ishikura H, Ikeda H, Abe H, Ohkuri T, Hiraga H, Isu K, Tsukahara T, Sato N, Kitamura H, Iwasaki N, Iwasaki N, et al: Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral immune system. Int J Oncol 30: 461-467, 2007.
APA
Ishikura, H., Ikeda, H., Abe, H., Ohkuri, T., Hiraga, H., Isu, K. ... Nishimura, T. (2007). Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral immune system. International Journal of Oncology, 30, 461-467. https://doi.org/10.3892/ijo.30.2.461
MLA
Ishikura, H., Ikeda, H., Abe, H., Ohkuri, T., Hiraga, H., Isu, K., Tsukahara, T., Sato, N., Kitamura, H., Iwasaki, N., Takeda, N., Minami, A., Nishimura, T."Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral immune system". International Journal of Oncology 30.2 (2007): 461-467.
Chicago
Ishikura, H., Ikeda, H., Abe, H., Ohkuri, T., Hiraga, H., Isu, K., Tsukahara, T., Sato, N., Kitamura, H., Iwasaki, N., Takeda, N., Minami, A., Nishimura, T."Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral immune system". International Journal of Oncology 30, no. 2 (2007): 461-467. https://doi.org/10.3892/ijo.30.2.461
Copy and paste a formatted citation
x
Spandidos Publications style
Ishikura H, Ikeda H, Abe H, Ohkuri T, Hiraga H, Isu K, Tsukahara T, Sato N, Kitamura H, Iwasaki N, Iwasaki N, et al: Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral immune system. Int J Oncol 30: 461-467, 2007.
APA
Ishikura, H., Ikeda, H., Abe, H., Ohkuri, T., Hiraga, H., Isu, K. ... Nishimura, T. (2007). Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral immune system. International Journal of Oncology, 30, 461-467. https://doi.org/10.3892/ijo.30.2.461
MLA
Ishikura, H., Ikeda, H., Abe, H., Ohkuri, T., Hiraga, H., Isu, K., Tsukahara, T., Sato, N., Kitamura, H., Iwasaki, N., Takeda, N., Minami, A., Nishimura, T."Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral immune system". International Journal of Oncology 30.2 (2007): 461-467.
Chicago
Ishikura, H., Ikeda, H., Abe, H., Ohkuri, T., Hiraga, H., Isu, K., Tsukahara, T., Sato, N., Kitamura, H., Iwasaki, N., Takeda, N., Minami, A., Nishimura, T."Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral immune system". International Journal of Oncology 30, no. 2 (2007): 461-467. https://doi.org/10.3892/ijo.30.2.461
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