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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2007 Volume 30 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2007 Volume 30 Issue 3

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Article

Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer

  • Authors:
    • Sharad S. Singhal
    • Jyotsana Singhal
    • Maya P. Nair
    • A. G. Lacko
    • Yogesh C. Awasthi
    • Sanjay Awasthi

  • View Affiliations / Copyright

    Affiliations: Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX 76019, USA
  • Pages: 717-725
    |
    Published online on: March 1, 2007
       https://doi.org/10.3892/ijo.30.3.717
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Abstract

RALBP1 (RLIP76) is the major transporter of doxorubicin (DOX) in lung cancer cells, and that the difference in sensitivity of small cell lung cancer (SCLC) cells to DOX is due to differential phosphorylation by PKCα. Our recent studies have suggested that RALBP1 present in MCF-7 breast cancer cells has significantly lower specific activity for transport of DOX than wild-type recombinant protein, and its level of expression is significantly lower than that in lung cancer cells. In the present study, we have explored whether or not this is a generalized phenomenon for breast cancer, and have compared the relative contributions of RALBP1 and the ABC-family transporter, ABCG2 to total DOX transport activities in two SCLC (H1417 and H1618), two non-small cell lung cancer (NSCLC) (H358 and H520), and three breast cancer (T-47D, MDA-MB231, and MCF-7) cell lines. Results of these studies show lower protein expression and specific activity of RALBP1 in all three breast cancer cell lines as compared with lung cancer cell lines. Furthermore, we demonstrate that RALBP1 contributes only a minor fraction of DOX transport activity in breast cancer cell lines, suggesting that greater DOX sensitivity of breast cancer may be related to lower RALBP1 transporter activity and that the transport mechanisms involved in multidrug resistance of lung and breast cancer are distinct.

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Copy and paste a formatted citation
Spandidos Publications style
Singhal SS, Singhal J, Nair MP, Lacko AG, Awasthi YC and Awasthi S: Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol 30: 717-725, 2007.
APA
Singhal, S.S., Singhal, J., Nair, M.P., Lacko, A.G., Awasthi, Y.C., & Awasthi, S. (2007). Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. International Journal of Oncology, 30, 717-725. https://doi.org/10.3892/ijo.30.3.717
MLA
Singhal, S. S., Singhal, J., Nair, M. P., Lacko, A. G., Awasthi, Y. C., Awasthi, S."Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer". International Journal of Oncology 30.3 (2007): 717-725.
Chicago
Singhal, S. S., Singhal, J., Nair, M. P., Lacko, A. G., Awasthi, Y. C., Awasthi, S."Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer". International Journal of Oncology 30, no. 3 (2007): 717-725. https://doi.org/10.3892/ijo.30.3.717
Copy and paste a formatted citation
x
Spandidos Publications style
Singhal SS, Singhal J, Nair MP, Lacko AG, Awasthi YC and Awasthi S: Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol 30: 717-725, 2007.
APA
Singhal, S.S., Singhal, J., Nair, M.P., Lacko, A.G., Awasthi, Y.C., & Awasthi, S. (2007). Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. International Journal of Oncology, 30, 717-725. https://doi.org/10.3892/ijo.30.3.717
MLA
Singhal, S. S., Singhal, J., Nair, M. P., Lacko, A. G., Awasthi, Y. C., Awasthi, S."Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer". International Journal of Oncology 30.3 (2007): 717-725.
Chicago
Singhal, S. S., Singhal, J., Nair, M. P., Lacko, A. G., Awasthi, Y. C., Awasthi, S."Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer". International Journal of Oncology 30, no. 3 (2007): 717-725. https://doi.org/10.3892/ijo.30.3.717
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