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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2007 Volume 30 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2007 Volume 30 Issue 4

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Article

TNF expressed by tumor-associated macrophages, but not microglia, can eliminate glioma

  • Authors:
    • Jiro Nakagawa
    • Masanao Saio
    • Noriyuki Tamakawa
    • Tatsuhiko Suwa
    • Alan B. Frey
    • Kenichi Nonaka
    • Naoki Umemura
    • Hisashi Imai
    • Guan-Feng Ouyang
    • Naoyuki Ohe
    • Hirohito Yano
    • Sinichi Yoshimura
    • Toru Iwama
    • Tsuyoshi Takami

  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan
  • Pages: 803-811
    |
    Published online on: April 1, 2007
       https://doi.org/10.3892/ijo.30.4.803
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Abstract

It is well known that tumor necrosis factor (TNF) can have both contrary and pleiotropic effects in anti-tumor immune response. In the present study, we prepared two different tumor cell-based immunotherapy models: MCA38 adenocarcinoma and GL261 glioma intracranial interleukin-2 (IL-2)-based. Each tumor was transfected to express IL-2 with or without expression of the soluble form of tumor necrosis factor receptor type II (sTNFRII). Although mice in which TNF is blocked survive longer than IL-2 alone (35.2 versus 26 days), the reverse was observed for GL261 glioma. The differential effect on tumor growth implies enhanced TNF sensitivity of GL261 compared to MCA38. This notion is supported by the observation that TNF induces apoptosis in GL261 but not MCA38 tumors. We further examined tumor infiltrating CD11b+F4/80+ macrophages (or tumor-associated macrophages: TAM) for TNF production in vivo and found that TAM express cell surface TNF implying a role in eliminating glioma cells mediated by the cell surface form of TNF.

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Copy and paste a formatted citation
Spandidos Publications style
Nakagawa J, Saio M, Tamakawa N, Suwa T, Frey AB, Nonaka K, Umemura N, Imai H, Ouyang G, Ohe N, Ohe N, et al: TNF expressed by tumor-associated macrophages, but not microglia, can eliminate glioma. Int J Oncol 30: 803-811, 2007.
APA
Nakagawa, J., Saio, M., Tamakawa, N., Suwa, T., Frey, A.B., Nonaka, K. ... Takami, T. (2007). TNF expressed by tumor-associated macrophages, but not microglia, can eliminate glioma. International Journal of Oncology, 30, 803-811. https://doi.org/10.3892/ijo.30.4.803
MLA
Nakagawa, J., Saio, M., Tamakawa, N., Suwa, T., Frey, A. B., Nonaka, K., Umemura, N., Imai, H., Ouyang, G., Ohe, N., Yano, H., Yoshimura, S., Iwama, T., Takami, T."TNF expressed by tumor-associated macrophages, but not microglia, can eliminate glioma". International Journal of Oncology 30.4 (2007): 803-811.
Chicago
Nakagawa, J., Saio, M., Tamakawa, N., Suwa, T., Frey, A. B., Nonaka, K., Umemura, N., Imai, H., Ouyang, G., Ohe, N., Yano, H., Yoshimura, S., Iwama, T., Takami, T."TNF expressed by tumor-associated macrophages, but not microglia, can eliminate glioma". International Journal of Oncology 30, no. 4 (2007): 803-811. https://doi.org/10.3892/ijo.30.4.803
Copy and paste a formatted citation
x
Spandidos Publications style
Nakagawa J, Saio M, Tamakawa N, Suwa T, Frey AB, Nonaka K, Umemura N, Imai H, Ouyang G, Ohe N, Ohe N, et al: TNF expressed by tumor-associated macrophages, but not microglia, can eliminate glioma. Int J Oncol 30: 803-811, 2007.
APA
Nakagawa, J., Saio, M., Tamakawa, N., Suwa, T., Frey, A.B., Nonaka, K. ... Takami, T. (2007). TNF expressed by tumor-associated macrophages, but not microglia, can eliminate glioma. International Journal of Oncology, 30, 803-811. https://doi.org/10.3892/ijo.30.4.803
MLA
Nakagawa, J., Saio, M., Tamakawa, N., Suwa, T., Frey, A. B., Nonaka, K., Umemura, N., Imai, H., Ouyang, G., Ohe, N., Yano, H., Yoshimura, S., Iwama, T., Takami, T."TNF expressed by tumor-associated macrophages, but not microglia, can eliminate glioma". International Journal of Oncology 30.4 (2007): 803-811.
Chicago
Nakagawa, J., Saio, M., Tamakawa, N., Suwa, T., Frey, A. B., Nonaka, K., Umemura, N., Imai, H., Ouyang, G., Ohe, N., Yano, H., Yoshimura, S., Iwama, T., Takami, T."TNF expressed by tumor-associated macrophages, but not microglia, can eliminate glioma". International Journal of Oncology 30, no. 4 (2007): 803-811. https://doi.org/10.3892/ijo.30.4.803
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