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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2007 Volume 30 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2007 Volume 30 Issue 4

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Article

Identification of DR9-restricted XAGE antigen on lung adenocarcinoma recognized by autologous CD4 T-cells

  • Authors:
    • Michihide Shimono
    • Akiko Uenaka
    • Yuji Noguchi
    • Shuichiro Sato
    • Hideo Okumura
    • Kazuhiko Nakagawa
    • Katsuyuki Kiura
    • Mitsune Tanimoto
    • Eiichi Nakayama

  • View Affiliations / Copyright

    Affiliations: Department of Immunology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan
  • Pages: 835-840
    |
    Published online on: April 1, 2007
       https://doi.org/10.3892/ijo.30.4.835
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Abstract

We previously demonstrated a dominant IgG response against XAGE-1b antigen in a lung cancer patient by serological analysis of antigens by recombinant expression cloning (SEREX) analysis using a cDNA library from the autologous OU-LU-6 tumor cell line. In this study, we investigated recognition of XAGE-1b on OU-LU-6 tumor by the patient CD4-expressing tumor-infiltrating lymphocytes (CD4 TIL). The response of CD4 TIL obtained from malignant pleural effusion was determined against autologous OU-LU-6 tumor cells and XAGE-1b mRNA-transfected PHA-stimulated CD4 T-cells (T-APC) from healthy individuals sharing HLA-DR with the patient by performing IFNγ secretion and ELISPOT assays. The patient CD4 TIL recognized OU-LU-6 in an HLA-DR-restricted manner and XAGE-1b mRNA-transfected T-APC derived from DRB1∗0901-sharing healthy donor (HD)1 and HD2, but not DRB1∗1101-sharing HD3 or HD4. Epitope analysis using 17 18-mer peptides with 12 overlapping amino acids revealed that the CD4 TIL recognized XAGE-1b 33-49. The findings suggest that the patient CD4 T-cells recognized the XAGE-1b 33-49-related epitope on autologous OU-LU-6 tumor cells in a manner restricted by DR∗0901.

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Copy and paste a formatted citation
Spandidos Publications style
Shimono M, Uenaka A, Noguchi Y, Sato S, Okumura H, Nakagawa K, Kiura K, Tanimoto M and Nakayama E: Identification of DR9-restricted XAGE antigen on lung adenocarcinoma recognized by autologous CD4 T-cells. Int J Oncol 30: 835-840, 2007.
APA
Shimono, M., Uenaka, A., Noguchi, Y., Sato, S., Okumura, H., Nakagawa, K. ... Nakayama, E. (2007). Identification of DR9-restricted XAGE antigen on lung adenocarcinoma recognized by autologous CD4 T-cells. International Journal of Oncology, 30, 835-840. https://doi.org/10.3892/ijo.30.4.835
MLA
Shimono, M., Uenaka, A., Noguchi, Y., Sato, S., Okumura, H., Nakagawa, K., Kiura, K., Tanimoto, M., Nakayama, E."Identification of DR9-restricted XAGE antigen on lung adenocarcinoma recognized by autologous CD4 T-cells". International Journal of Oncology 30.4 (2007): 835-840.
Chicago
Shimono, M., Uenaka, A., Noguchi, Y., Sato, S., Okumura, H., Nakagawa, K., Kiura, K., Tanimoto, M., Nakayama, E."Identification of DR9-restricted XAGE antigen on lung adenocarcinoma recognized by autologous CD4 T-cells". International Journal of Oncology 30, no. 4 (2007): 835-840. https://doi.org/10.3892/ijo.30.4.835
Copy and paste a formatted citation
x
Spandidos Publications style
Shimono M, Uenaka A, Noguchi Y, Sato S, Okumura H, Nakagawa K, Kiura K, Tanimoto M and Nakayama E: Identification of DR9-restricted XAGE antigen on lung adenocarcinoma recognized by autologous CD4 T-cells. Int J Oncol 30: 835-840, 2007.
APA
Shimono, M., Uenaka, A., Noguchi, Y., Sato, S., Okumura, H., Nakagawa, K. ... Nakayama, E. (2007). Identification of DR9-restricted XAGE antigen on lung adenocarcinoma recognized by autologous CD4 T-cells. International Journal of Oncology, 30, 835-840. https://doi.org/10.3892/ijo.30.4.835
MLA
Shimono, M., Uenaka, A., Noguchi, Y., Sato, S., Okumura, H., Nakagawa, K., Kiura, K., Tanimoto, M., Nakayama, E."Identification of DR9-restricted XAGE antigen on lung adenocarcinoma recognized by autologous CD4 T-cells". International Journal of Oncology 30.4 (2007): 835-840.
Chicago
Shimono, M., Uenaka, A., Noguchi, Y., Sato, S., Okumura, H., Nakagawa, K., Kiura, K., Tanimoto, M., Nakayama, E."Identification of DR9-restricted XAGE antigen on lung adenocarcinoma recognized by autologous CD4 T-cells". International Journal of Oncology 30, no. 4 (2007): 835-840. https://doi.org/10.3892/ijo.30.4.835
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