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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2007 Volume 30 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2007 Volume 30 Issue 5

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Article

Genomic and transcriptomic prognostic factors in R0 Dukes B and C colorectal cancer patients

  • Authors:
    • Elisenda Vendrell
    • Maria Ribas
    • Joan Valls
    • Xavier Solé
    • Mònica Grau
    • Victor Moreno
    • Gabriel Capellà
    • Miguel A. Peinado
  • View Affiliations / Copyright

    Affiliations: Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet, Barcelona, Catalonia, Spain
  • Pages: 1099-1107
    |
    Published online on: May 1, 2007
       https://doi.org/10.3892/ijo.30.5.1099
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Abstract

The advent of various ‘omic’ technologies has increased expectations in the field of biomarkers. In an attempt to clarify how different strategies may contribute to improving prognostic classification and to identify new predictors of patient outcome we analyzed genomic and transcriptomic profiles in a series of R0 Dukes B and C colorectal carcinomas. We have compared the predictive capability of each approach against conventional clinicopathological and molecular parameters. At a genomic level, gains at 11q including amplification at 11q13 were an indicator of poorer outcome. In transcriptomic analyses we identified 68 genes whose expression levels correlated with survival (p<0.01) and included overexpression of WASF1, NFE2L2, and MMP9, and underexpression of ITGAL, TSC2, and SDF2. Gene expression levels paralleled chromosomal changes only in 56% of the genes, suggesting that, as a general trend, the direct effect of chromosomal copy number changes on gene expression levels is minimal. Classification of tumors by genomic and transcriptomic signatures resulted in non-overlapping subgroups and was not of prognostic value. We conclude that genomic and transcriptomic profiling of colorectal carcinomas may contribute as novel prognostic markers, but it does not improve outcome prediction when global profiles or signatures are considered.

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Copy and paste a formatted citation
Spandidos Publications style
Vendrell E, Ribas M, Valls J, Solé X, Grau M, Moreno V, Capellà G and Peinado MA: Genomic and transcriptomic prognostic factors in R0 Dukes B and C colorectal cancer patients. Int J Oncol 30: 1099-1107, 2007.
APA
Vendrell, E., Ribas, M., Valls, J., Solé, X., Grau, M., Moreno, V. ... Peinado, M.A. (2007). Genomic and transcriptomic prognostic factors in R0 Dukes B and C colorectal cancer patients. International Journal of Oncology, 30, 1099-1107. https://doi.org/10.3892/ijo.30.5.1099
MLA
Vendrell, E., Ribas, M., Valls, J., Solé, X., Grau, M., Moreno, V., Capellà, G., Peinado, M. A."Genomic and transcriptomic prognostic factors in R0 Dukes B and C colorectal cancer patients". International Journal of Oncology 30.5 (2007): 1099-1107.
Chicago
Vendrell, E., Ribas, M., Valls, J., Solé, X., Grau, M., Moreno, V., Capellà, G., Peinado, M. A."Genomic and transcriptomic prognostic factors in R0 Dukes B and C colorectal cancer patients". International Journal of Oncology 30, no. 5 (2007): 1099-1107. https://doi.org/10.3892/ijo.30.5.1099
Copy and paste a formatted citation
x
Spandidos Publications style
Vendrell E, Ribas M, Valls J, Solé X, Grau M, Moreno V, Capellà G and Peinado MA: Genomic and transcriptomic prognostic factors in R0 Dukes B and C colorectal cancer patients. Int J Oncol 30: 1099-1107, 2007.
APA
Vendrell, E., Ribas, M., Valls, J., Solé, X., Grau, M., Moreno, V. ... Peinado, M.A. (2007). Genomic and transcriptomic prognostic factors in R0 Dukes B and C colorectal cancer patients. International Journal of Oncology, 30, 1099-1107. https://doi.org/10.3892/ijo.30.5.1099
MLA
Vendrell, E., Ribas, M., Valls, J., Solé, X., Grau, M., Moreno, V., Capellà, G., Peinado, M. A."Genomic and transcriptomic prognostic factors in R0 Dukes B and C colorectal cancer patients". International Journal of Oncology 30.5 (2007): 1099-1107.
Chicago
Vendrell, E., Ribas, M., Valls, J., Solé, X., Grau, M., Moreno, V., Capellà, G., Peinado, M. A."Genomic and transcriptomic prognostic factors in R0 Dukes B and C colorectal cancer patients". International Journal of Oncology 30, no. 5 (2007): 1099-1107. https://doi.org/10.3892/ijo.30.5.1099
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