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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2007 Volume 31 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2007 Volume 31 Issue 1

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Article

Diversity of common alternative splicing variants of human cytochrome P450 1A1 and their association to carcinogenesis

  • Authors:
    • Mario Bauer
    • Olf Herbarth
    • Susanne Rudzok
    • Eike Schmücking
    • Andrea Müller
    • Gabriela Aust
    • Carolin Gräbsch

  • View Affiliations / Copyright

    Affiliations: Dept. of Human Exposure Research and Epidemiology, Helmholtz Centre for Environmental Research - UFZ, D-04318 Leipzig, Germany. mario.bauer@ufz.de
  • Pages: 211-218
    |
    Published online on: July 1, 2007
       https://doi.org/10.3892/ijo.31.1.211
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Abstract

Cytochrome P450 1A1 (CYP1A1) belongs to the enzymes of biotransformation of phase I. CYP1A1 performs the catalytic activation of exogenous and endogenous substrates to more carcinogenic metabolites. Overexpression of the wild-type and a recently described splice variant (CYP1A1v, ovarian cancer) are attributed to neoplastic transformation. Here we describe novel CYP1A1 splicing variants commonly and frequently transcribed in leucocytes of healthy volunteers, separated from variants exclusively expressed in tumour cell lines. Interestingly, all the novel splicing variants in leukocytes are generated by employing of two nested splice site pairs, one outer canonical and one inner non-canonical splice site pair, within the exon 2 of the human CYP1A1. In general, the frequent presence of common splicing variants in healthy volunteers has to be consider as a physiological feature of human CYP1A1 transcription process, rather than a signature of carcinogenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Bauer M, Herbarth O, Rudzok S, Schmücking E, Müller A, Aust G and Gräbsch C: Diversity of common alternative splicing variants of human cytochrome P450 1A1 and their association to carcinogenesis. Int J Oncol 31: 211-218, 2007.
APA
Bauer, M., Herbarth, O., Rudzok, S., Schmücking, E., Müller, A., Aust, G., & Gräbsch, C. (2007). Diversity of common alternative splicing variants of human cytochrome P450 1A1 and their association to carcinogenesis. International Journal of Oncology, 31, 211-218. https://doi.org/10.3892/ijo.31.1.211
MLA
Bauer, M., Herbarth, O., Rudzok, S., Schmücking, E., Müller, A., Aust, G., Gräbsch, C."Diversity of common alternative splicing variants of human cytochrome P450 1A1 and their association to carcinogenesis". International Journal of Oncology 31.1 (2007): 211-218.
Chicago
Bauer, M., Herbarth, O., Rudzok, S., Schmücking, E., Müller, A., Aust, G., Gräbsch, C."Diversity of common alternative splicing variants of human cytochrome P450 1A1 and their association to carcinogenesis". International Journal of Oncology 31, no. 1 (2007): 211-218. https://doi.org/10.3892/ijo.31.1.211
Copy and paste a formatted citation
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Spandidos Publications style
Bauer M, Herbarth O, Rudzok S, Schmücking E, Müller A, Aust G and Gräbsch C: Diversity of common alternative splicing variants of human cytochrome P450 1A1 and their association to carcinogenesis. Int J Oncol 31: 211-218, 2007.
APA
Bauer, M., Herbarth, O., Rudzok, S., Schmücking, E., Müller, A., Aust, G., & Gräbsch, C. (2007). Diversity of common alternative splicing variants of human cytochrome P450 1A1 and their association to carcinogenesis. International Journal of Oncology, 31, 211-218. https://doi.org/10.3892/ijo.31.1.211
MLA
Bauer, M., Herbarth, O., Rudzok, S., Schmücking, E., Müller, A., Aust, G., Gräbsch, C."Diversity of common alternative splicing variants of human cytochrome P450 1A1 and their association to carcinogenesis". International Journal of Oncology 31.1 (2007): 211-218.
Chicago
Bauer, M., Herbarth, O., Rudzok, S., Schmücking, E., Müller, A., Aust, G., Gräbsch, C."Diversity of common alternative splicing variants of human cytochrome P450 1A1 and their association to carcinogenesis". International Journal of Oncology 31, no. 1 (2007): 211-218. https://doi.org/10.3892/ijo.31.1.211
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