Evolution of the human MUC1 oncoprotein

  • Authors:
    • Sekhar Duraisamy
    • Turner Kufe
    • Selvi Ramasamy
    • Donald Kufe
  • View Affiliations

  • Published online on: September 1, 2007     https://doi.org/10.3892/ijo.31.3.671
  • Pages: 671-677
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The mucin (MUC) family consists of secreted and membrane-bound forms. The transmembrane mucin 1 (MUC1) is a heterodimer that is aberrantly overexpressed by diverse human carcinomas and certain hematologic malignancies. The MUC1 N-terminal (MUC1-N) and C-terminal (MUC1-C) subunits are generated by autocleavage within a SEA domain. The MUC1 cytoplasmic domain (MUC1-CD) located downstream of the SEA domain is sufficient for the induction of anchorage-independent growth and tumorigenicity; however, no information is available regarding the origin of these transforming sequences. Previous work demonstrated that, except for the SEA domain, MUC1 has no sequence homology with other membrane-bound mucins. The present results demonstrate that MUC1-CD evolved from repeat regions in the MUC5B secreted mucin. We also show that MUC1 sequences upstream to the SEA domain emerged from MUC5B. These findings indicate that both the MUC1-N and MUC1-C subunits evolved from secreted gel-forming mucins and that the MUC1-CD oncogenic function emerged by diversification after evolution from MUC5B.

Related Articles

Journal Cover

September 2007
Volume 31 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Duraisamy S, Kufe T, Ramasamy S and Kufe D: Evolution of the human MUC1 oncoprotein. Int J Oncol 31: 671-677, 2007
APA
Duraisamy, S., Kufe, T., Ramasamy, S., & Kufe, D. (2007). Evolution of the human MUC1 oncoprotein. International Journal of Oncology, 31, 671-677. https://doi.org/10.3892/ijo.31.3.671
MLA
Duraisamy, S., Kufe, T., Ramasamy, S., Kufe, D."Evolution of the human MUC1 oncoprotein". International Journal of Oncology 31.3 (2007): 671-677.
Chicago
Duraisamy, S., Kufe, T., Ramasamy, S., Kufe, D."Evolution of the human MUC1 oncoprotein". International Journal of Oncology 31, no. 3 (2007): 671-677. https://doi.org/10.3892/ijo.31.3.671