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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2007 Volume 31 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2007 Volume 31 Issue 4

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Article

Epigenetic inactivation of the CHFR gene in cervical cancer contributes to sensitivity to taxanes

  • Authors:
    • Kouji Banno
    • Megumi Yanokura
    • Makiko Kawaguchi
    • Yoshiko Kuwabara
    • Jyunko Akiyoshi
    • Yusuke Kobayashi
    • Takashi Iwata
    • Akira Hirasawa
    • Takuma Fujii
    • Nobuyuki Susumu
    • Kastumi Tsukazaki
    • Daisuke Aoki

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, Japan. kbanno@sc.itc.keio.ac.jp
  • Pages: 713-720
    |
    Published online on: October 1, 2007
       https://doi.org/10.3892/ijo.31.4.713
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Abstract

A relationship between inactivation of mitotic checkpoint genes and sensitivity of cancer cells to anticancer agents has been reported. We investigated the effect of epigenetic inactivation by aberrant hypermethylation of the mitotic checkpoint gene CHFR (checkpoint with forkhead and ring finger) on the sensitivity of cervical cancer cells to taxanes. Methylation-specific PCR (MSP) of cervical smears showed aberrant methylation of CHFR in 12.3% (2/14) of adenocarcinoma specimens. In contrast, aberrant DNA methylation was not detected in normal cervical cells or squamous cell carcinoma cells. Aberrant methylation of CHFR was also analyzed in 6 human cervical carcinoma-derived cell lines and was observed in SKG-IIIb and HeLa cells. These cell lines showed high sensitivity to taxanes, but became taxane-resistant upon treatment with 5-azacytidine. Furthermore, suppression of CHFR expression in siRNA-transfected SKG-IIIa cells caused increased sensitivity to taxanes. In conclusion, aberrant methylation of the CHFR gene may be useful as a molecular marker for selection of therapy for patients with cervical adenocarcinoma with a poor prognosis, and may also suggest a new therapeutic strategy of targeting CHFR in cervical cancer. To our knowledge, this study is the first to examine epigenetic inactivation by aberrant hypermethylation of CHFR in cervical cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Banno K, Yanokura M, Kawaguchi M, Kuwabara Y, Akiyoshi J, Kobayashi Y, Iwata T, Hirasawa A, Fujii T, Susumu N, Susumu N, et al: Epigenetic inactivation of the CHFR gene in cervical cancer contributes to sensitivity to taxanes. Int J Oncol 31: 713-720, 2007.
APA
Banno, K., Yanokura, M., Kawaguchi, M., Kuwabara, Y., Akiyoshi, J., Kobayashi, Y. ... Aoki, D. (2007). Epigenetic inactivation of the CHFR gene in cervical cancer contributes to sensitivity to taxanes. International Journal of Oncology, 31, 713-720. https://doi.org/10.3892/ijo.31.4.713
MLA
Banno, K., Yanokura, M., Kawaguchi, M., Kuwabara, Y., Akiyoshi, J., Kobayashi, Y., Iwata, T., Hirasawa, A., Fujii, T., Susumu, N., Tsukazaki, K., Aoki, D."Epigenetic inactivation of the CHFR gene in cervical cancer contributes to sensitivity to taxanes". International Journal of Oncology 31.4 (2007): 713-720.
Chicago
Banno, K., Yanokura, M., Kawaguchi, M., Kuwabara, Y., Akiyoshi, J., Kobayashi, Y., Iwata, T., Hirasawa, A., Fujii, T., Susumu, N., Tsukazaki, K., Aoki, D."Epigenetic inactivation of the CHFR gene in cervical cancer contributes to sensitivity to taxanes". International Journal of Oncology 31, no. 4 (2007): 713-720. https://doi.org/10.3892/ijo.31.4.713
Copy and paste a formatted citation
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Spandidos Publications style
Banno K, Yanokura M, Kawaguchi M, Kuwabara Y, Akiyoshi J, Kobayashi Y, Iwata T, Hirasawa A, Fujii T, Susumu N, Susumu N, et al: Epigenetic inactivation of the CHFR gene in cervical cancer contributes to sensitivity to taxanes. Int J Oncol 31: 713-720, 2007.
APA
Banno, K., Yanokura, M., Kawaguchi, M., Kuwabara, Y., Akiyoshi, J., Kobayashi, Y. ... Aoki, D. (2007). Epigenetic inactivation of the CHFR gene in cervical cancer contributes to sensitivity to taxanes. International Journal of Oncology, 31, 713-720. https://doi.org/10.3892/ijo.31.4.713
MLA
Banno, K., Yanokura, M., Kawaguchi, M., Kuwabara, Y., Akiyoshi, J., Kobayashi, Y., Iwata, T., Hirasawa, A., Fujii, T., Susumu, N., Tsukazaki, K., Aoki, D."Epigenetic inactivation of the CHFR gene in cervical cancer contributes to sensitivity to taxanes". International Journal of Oncology 31.4 (2007): 713-720.
Chicago
Banno, K., Yanokura, M., Kawaguchi, M., Kuwabara, Y., Akiyoshi, J., Kobayashi, Y., Iwata, T., Hirasawa, A., Fujii, T., Susumu, N., Tsukazaki, K., Aoki, D."Epigenetic inactivation of the CHFR gene in cervical cancer contributes to sensitivity to taxanes". International Journal of Oncology 31, no. 4 (2007): 713-720. https://doi.org/10.3892/ijo.31.4.713
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