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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2007 Volume 31 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2007 Volume 31 Issue 4

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Article

The receptor tyrosine kinase Tie1 is expressed and activated in epithelial tumour cell lines

  • Authors:
    • Kathryn A. Rees
    • Harprit Singh
    • Nicholas P.J. Brindle

  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Sciences, University of Leicester, Leicester, LE2 7LX, UK
  • Pages: 893-897
    |
    Published online on: October 1, 2007
       https://doi.org/10.3892/ijo.31.4.893
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Abstract

The receptor tyrosine kinase Tie1 is expressed primarily in vascular endothelial cells. The receptor has also been detected in epithelial tumours in breast, thyroid and gastric cancers and in tumour cell lines where it appears as a 45 kDa truncated receptor fragment. In this study, we show that in addition to truncated Tie1, breast and colon tumour cell lines express a full-length Tie1 holoreceptor. In contrast to the situation in endothelial cells, Tie1 truncation is not activated by phorbol esters and generation of truncated Tie1 does not occur via a metalloprotease-inhibitor sensitive mechanism. Examination of the phosphorylation status of Tie1 revealed both the holoreceptor and truncated receptor to be constitutively activated in MCF-7 cells. These data indicate that Tie1 expressed in epithelial tumour cell lines is present in holoreceptor and truncated forms, and in MCF-7 cells both forms are constitutively phosphorylated and competent to signal. Our findings suggest therefore that anti-angiogenic strategies targeting the angiopoietin/Tie system in tumour microvasculature could also have additional direct effects on the tumour epithelial cells within those tumours in which there is also extravascular expression of the Tie1 receptor tyrosine kinase.

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Copy and paste a formatted citation
Spandidos Publications style
Rees KA, Singh H and Brindle NP: The receptor tyrosine kinase Tie1 is expressed and activated in epithelial tumour cell lines. Int J Oncol 31: 893-897, 2007.
APA
Rees, K.A., Singh, H., & Brindle, N.P. (2007). The receptor tyrosine kinase Tie1 is expressed and activated in epithelial tumour cell lines. International Journal of Oncology, 31, 893-897. https://doi.org/10.3892/ijo.31.4.893
MLA
Rees, K. A., Singh, H., Brindle, N. P."The receptor tyrosine kinase Tie1 is expressed and activated in epithelial tumour cell lines". International Journal of Oncology 31.4 (2007): 893-897.
Chicago
Rees, K. A., Singh, H., Brindle, N. P."The receptor tyrosine kinase Tie1 is expressed and activated in epithelial tumour cell lines". International Journal of Oncology 31, no. 4 (2007): 893-897. https://doi.org/10.3892/ijo.31.4.893
Copy and paste a formatted citation
x
Spandidos Publications style
Rees KA, Singh H and Brindle NP: The receptor tyrosine kinase Tie1 is expressed and activated in epithelial tumour cell lines. Int J Oncol 31: 893-897, 2007.
APA
Rees, K.A., Singh, H., & Brindle, N.P. (2007). The receptor tyrosine kinase Tie1 is expressed and activated in epithelial tumour cell lines. International Journal of Oncology, 31, 893-897. https://doi.org/10.3892/ijo.31.4.893
MLA
Rees, K. A., Singh, H., Brindle, N. P."The receptor tyrosine kinase Tie1 is expressed and activated in epithelial tumour cell lines". International Journal of Oncology 31.4 (2007): 893-897.
Chicago
Rees, K. A., Singh, H., Brindle, N. P."The receptor tyrosine kinase Tie1 is expressed and activated in epithelial tumour cell lines". International Journal of Oncology 31, no. 4 (2007): 893-897. https://doi.org/10.3892/ijo.31.4.893
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