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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2007 Volume 31 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2007 Volume 31 Issue 4

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Article

Cobalt chloride induces apoptosis and zinc chloride suppresses cobalt-induced apoptosis by Bcl-2 expression in human submandibular gland HSG cells

  • Authors:
    • Kazumi Akita
    • Hirohiko Okamura
    • Kaya Yoshida
    • Hiroyuki Morimoto
    • Hiroaki Ogawa-Iyehara
    • Tatsuji Haneji

  • View Affiliations / Copyright

    Affiliations: Department of Histology and Oral Histology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8504, Japan
  • Pages: 923-929
    |
    Published online on: October 1, 2007
       https://doi.org/10.3892/ijo.31.4.923
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Abstract

To determine the effects of cobalt chloride on human submandibular gland cells, HSG cells were exposed to various concentrations of cobalt chloride. Cobalt chloride induced cytotoxicity and cell death in HSG cells as determined by phase-contrast microscopy and WST-1 cell viability assay. By using the Hoechst 33342 staining, marked nuclear condensation and fragmentation of chromatin were observed in cobalt chloride-treated cells. Cobalt chloride induced DNA ladder formation in HSG cells in both dose- and time-dependent manner with maximal effect at a concentration of 0.5 mM and 48 h, respectively. Cobalt chloride inhibited the expression of both Bcl-2 protein and mRNA in dose- and time-dependent manner. Zinc chloride recovered the cobalt-suppressed Bcl-2 expression and protected against cobalt-induced apoptosis in HSG cells. Our results show that the pathway of the apoptosis in HSG cells is regulated by cobalt chloride and zinc chloride. Our results also indicate that cobalt-induced apoptotic steps in HSG cells are related to the production of Bcl-2 protein.

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Copy and paste a formatted citation
Spandidos Publications style
Akita K, Okamura H, Yoshida K, Morimoto H, Ogawa-Iyehara H and Haneji T: Cobalt chloride induces apoptosis and zinc chloride suppresses cobalt-induced apoptosis by Bcl-2 expression in human submandibular gland HSG cells. Int J Oncol 31: 923-929, 2007.
APA
Akita, K., Okamura, H., Yoshida, K., Morimoto, H., Ogawa-Iyehara, H., & Haneji, T. (2007). Cobalt chloride induces apoptosis and zinc chloride suppresses cobalt-induced apoptosis by Bcl-2 expression in human submandibular gland HSG cells. International Journal of Oncology, 31, 923-929. https://doi.org/10.3892/ijo.31.4.923
MLA
Akita, K., Okamura, H., Yoshida, K., Morimoto, H., Ogawa-Iyehara, H., Haneji, T."Cobalt chloride induces apoptosis and zinc chloride suppresses cobalt-induced apoptosis by Bcl-2 expression in human submandibular gland HSG cells". International Journal of Oncology 31.4 (2007): 923-929.
Chicago
Akita, K., Okamura, H., Yoshida, K., Morimoto, H., Ogawa-Iyehara, H., Haneji, T."Cobalt chloride induces apoptosis and zinc chloride suppresses cobalt-induced apoptosis by Bcl-2 expression in human submandibular gland HSG cells". International Journal of Oncology 31, no. 4 (2007): 923-929. https://doi.org/10.3892/ijo.31.4.923
Copy and paste a formatted citation
x
Spandidos Publications style
Akita K, Okamura H, Yoshida K, Morimoto H, Ogawa-Iyehara H and Haneji T: Cobalt chloride induces apoptosis and zinc chloride suppresses cobalt-induced apoptosis by Bcl-2 expression in human submandibular gland HSG cells. Int J Oncol 31: 923-929, 2007.
APA
Akita, K., Okamura, H., Yoshida, K., Morimoto, H., Ogawa-Iyehara, H., & Haneji, T. (2007). Cobalt chloride induces apoptosis and zinc chloride suppresses cobalt-induced apoptosis by Bcl-2 expression in human submandibular gland HSG cells. International Journal of Oncology, 31, 923-929. https://doi.org/10.3892/ijo.31.4.923
MLA
Akita, K., Okamura, H., Yoshida, K., Morimoto, H., Ogawa-Iyehara, H., Haneji, T."Cobalt chloride induces apoptosis and zinc chloride suppresses cobalt-induced apoptosis by Bcl-2 expression in human submandibular gland HSG cells". International Journal of Oncology 31.4 (2007): 923-929.
Chicago
Akita, K., Okamura, H., Yoshida, K., Morimoto, H., Ogawa-Iyehara, H., Haneji, T."Cobalt chloride induces apoptosis and zinc chloride suppresses cobalt-induced apoptosis by Bcl-2 expression in human submandibular gland HSG cells". International Journal of Oncology 31, no. 4 (2007): 923-929. https://doi.org/10.3892/ijo.31.4.923
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