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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2007 Volume 31 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2007 Volume 31 Issue 6

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Article

Estradiol-17β regulates vascular endothelial growth factor and Bcl-2 expression in HHUA cells

  • Authors:
    • Xu Zhi
    • Ken-Ichi Honda
    • Toshiyuki Sumi
    • Tomoyo Yasui
    • Hiroyuki Nobeyama
    • Hiroyuki Yoshida
    • Osamu Ishiko

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka 545-8585, Japan. m1151239@med.osaka-cu.ac.jp
  • Pages: 1333-1338
    |
    Published online on: December 1, 2007
       https://doi.org/10.3892/ijo.31.6.1333
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Abstract

HHUA, a rare endometrial cancer cell line expressing the estrogen receptor (ER), was adopted to investigate the expression of vascular endothelial growth factor (VEGF), erythropoietin (Epo), Bcl-2 and p53 under the administration of estradiol-17β (E2). Based on quantitative real-time reverse transcription polymerase chain reaction assays, both VEGF and Bcl-2 mRNA levels decreased in a dose-dependent manner, although VEGF levels were increased in a time-dependent manner; no significant change was found for Epo and p53. An immunocytochemical study also showed the suppressed expression of VEGF and Bcl-2 under E2 induction. Both ERα and ERβ mRNAs were detected in HHUA cells with ERβ expression being predominantly higher than that of ERα, which is the converse of the pattern seen in normal endometria. The present study shows the E2-downregulated expression of VEGF and Bcl-2, and reveals a disrupted balance of ERα and ERβ expression, which should be taken into consideration to understand the particularity of E2-regulated gene expression in HHUA cells.

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Copy and paste a formatted citation
Spandidos Publications style
Zhi X, Honda K, Sumi T, Yasui T, Nobeyama H, Yoshida H and Ishiko O: Estradiol-17β regulates vascular endothelial growth factor and Bcl-2 expression in HHUA cells. Int J Oncol 31: 1333-1338, 2007.
APA
Zhi, X., Honda, K., Sumi, T., Yasui, T., Nobeyama, H., Yoshida, H., & Ishiko, O. (2007). Estradiol-17β regulates vascular endothelial growth factor and Bcl-2 expression in HHUA cells. International Journal of Oncology, 31, 1333-1338. https://doi.org/10.3892/ijo.31.6.1333
MLA
Zhi, X., Honda, K., Sumi, T., Yasui, T., Nobeyama, H., Yoshida, H., Ishiko, O."Estradiol-17β regulates vascular endothelial growth factor and Bcl-2 expression in HHUA cells". International Journal of Oncology 31.6 (2007): 1333-1338.
Chicago
Zhi, X., Honda, K., Sumi, T., Yasui, T., Nobeyama, H., Yoshida, H., Ishiko, O."Estradiol-17β regulates vascular endothelial growth factor and Bcl-2 expression in HHUA cells". International Journal of Oncology 31, no. 6 (2007): 1333-1338. https://doi.org/10.3892/ijo.31.6.1333
Copy and paste a formatted citation
x
Spandidos Publications style
Zhi X, Honda K, Sumi T, Yasui T, Nobeyama H, Yoshida H and Ishiko O: Estradiol-17β regulates vascular endothelial growth factor and Bcl-2 expression in HHUA cells. Int J Oncol 31: 1333-1338, 2007.
APA
Zhi, X., Honda, K., Sumi, T., Yasui, T., Nobeyama, H., Yoshida, H., & Ishiko, O. (2007). Estradiol-17β regulates vascular endothelial growth factor and Bcl-2 expression in HHUA cells. International Journal of Oncology, 31, 1333-1338. https://doi.org/10.3892/ijo.31.6.1333
MLA
Zhi, X., Honda, K., Sumi, T., Yasui, T., Nobeyama, H., Yoshida, H., Ishiko, O."Estradiol-17β regulates vascular endothelial growth factor and Bcl-2 expression in HHUA cells". International Journal of Oncology 31.6 (2007): 1333-1338.
Chicago
Zhi, X., Honda, K., Sumi, T., Yasui, T., Nobeyama, H., Yoshida, H., Ishiko, O."Estradiol-17β regulates vascular endothelial growth factor and Bcl-2 expression in HHUA cells". International Journal of Oncology 31, no. 6 (2007): 1333-1338. https://doi.org/10.3892/ijo.31.6.1333
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