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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2008 Volume 32 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2008 Volume 32 Issue 1

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Article

GSH loss per se does not affect neuroblastoma survival and is not genotoxic

  • Authors:
    • Barbara Marengo
    • Emanuela Balbis
    • Stefania Patriarca
    • Chiara De Ciucis
    • Annalisa Furfaro
    • Mariapaola Nitti
    • Umberto Maria Marinari
    • Maria Adelaide Pronzato
    • Nicola Traverso
    • Cinzia Domenicotti

  • View Affiliations / Copyright

    Affiliations: G. Gaslini Institute, Gaslini Hospital, I-16148 Genoa, Italy
  • Pages: 121-127
    |
    Published online on: January 1, 2008
       https://doi.org/10.3892/ijo.32.1.121
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Abstract

Depletion of glutathione (GSH) by buthionine sulfoximine (BSO) has been reported to be toxic against some cancer cells and to sensitize many tumours including neuroblastoma (NB) to anticancer drugs. The balance between the production rate of reactive oxygen species (ROS) and the function of GSH affects the intracellular reduction-oxidation status, which is crucial for the regulation of several cellular physiological functions. To assess the role of glutathione in neuroblastoma therapy, the effect of sublethal concentrations of BSO was studied in a panel of neuroblastoma cell lines characterized by different MYCN status. We found that GSH depletion per se not accompanied by ROS overproduction, does not affect cell survival, and is not genotoxic but induces HO-1 expression in GI-ME-N cell line, a representative example of MYCN non-amplified NB cells, having the highest basal levels of GSH among the tested NB lines. These observations might open a novel therapeutic window based on the possibility of modulating the cellular ‘activity’ of GSH.

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Copy and paste a formatted citation
Spandidos Publications style
Marengo B, Balbis E, Patriarca S, De Ciucis C, Furfaro A, Nitti M, Marinari UM, Pronzato MA, Traverso N, Domenicotti C, Domenicotti C, et al: GSH loss per se does not affect neuroblastoma survival and is not genotoxic. Int J Oncol 32: 121-127, 2008.
APA
Marengo, B., Balbis, E., Patriarca, S., De Ciucis, C., Furfaro, A., Nitti, M. ... Domenicotti, C. (2008). GSH loss per se does not affect neuroblastoma survival and is not genotoxic. International Journal of Oncology, 32, 121-127. https://doi.org/10.3892/ijo.32.1.121
MLA
Marengo, B., Balbis, E., Patriarca, S., De Ciucis, C., Furfaro, A., Nitti, M., Marinari, U. M., Pronzato, M. A., Traverso, N., Domenicotti, C."GSH loss per se does not affect neuroblastoma survival and is not genotoxic". International Journal of Oncology 32.1 (2008): 121-127.
Chicago
Marengo, B., Balbis, E., Patriarca, S., De Ciucis, C., Furfaro, A., Nitti, M., Marinari, U. M., Pronzato, M. A., Traverso, N., Domenicotti, C."GSH loss per se does not affect neuroblastoma survival and is not genotoxic". International Journal of Oncology 32, no. 1 (2008): 121-127. https://doi.org/10.3892/ijo.32.1.121
Copy and paste a formatted citation
x
Spandidos Publications style
Marengo B, Balbis E, Patriarca S, De Ciucis C, Furfaro A, Nitti M, Marinari UM, Pronzato MA, Traverso N, Domenicotti C, Domenicotti C, et al: GSH loss per se does not affect neuroblastoma survival and is not genotoxic. Int J Oncol 32: 121-127, 2008.
APA
Marengo, B., Balbis, E., Patriarca, S., De Ciucis, C., Furfaro, A., Nitti, M. ... Domenicotti, C. (2008). GSH loss per se does not affect neuroblastoma survival and is not genotoxic. International Journal of Oncology, 32, 121-127. https://doi.org/10.3892/ijo.32.1.121
MLA
Marengo, B., Balbis, E., Patriarca, S., De Ciucis, C., Furfaro, A., Nitti, M., Marinari, U. M., Pronzato, M. A., Traverso, N., Domenicotti, C."GSH loss per se does not affect neuroblastoma survival and is not genotoxic". International Journal of Oncology 32.1 (2008): 121-127.
Chicago
Marengo, B., Balbis, E., Patriarca, S., De Ciucis, C., Furfaro, A., Nitti, M., Marinari, U. M., Pronzato, M. A., Traverso, N., Domenicotti, C."GSH loss per se does not affect neuroblastoma survival and is not genotoxic". International Journal of Oncology 32, no. 1 (2008): 121-127. https://doi.org/10.3892/ijo.32.1.121
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