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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
January 2008 Volume 32 Issue 1

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Article

Balanitin-6 and -7: Diosgenyl saponins isolated from Balanites aegyptiaca Del. display significant anti-tumor activity in vitro and in vivo

Charlemagne Gnoula, Véronique Mégalizzi, Nancy De Nève, Sébastien Sauvage, Fabrice Ribaucour, Pierre Guissou, Pierre Duez, Jacques Dubois, Laurent Ingrassia, Florence Lefranc, Robert Kiss, Tatjana Mijatovic
Pages: 5-15
Published online on: 01 January 2008

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Article

Apoptotic genes as potential markers of metastatic phenotype in human osteosarcoma cell lines

Cinzia Zucchini, Anna Rocchi, Maria Cristina Manara, Paola De Sanctis, Cristina Capanni, Michele Bianchini, Paolo Carinci, Katia Scotlandi, Luisa Valvassori
Pages: 17-31
Published online on: 01 January 2008

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Article

aP2-Cre-mediated expression activation of an oncogenic PLAG1 transgene results in cavernous angiomatosis in mice

Frederik Van Dyck, Ilse Scroyen, Jeroen Declercq, Raf Sciot, Barbara Kahn, Roger Lijnen, Wim J.M. Van de Ven
Pages: 33-40
Published online on: 01 January 2008

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Article

Vascular endothelial growth factor is an autocrine survival factor for breast tumour cells under hypoxia

Martin P. Barr, David J. Bouchier-Hayes, Judith J. Harmey
Pages: 41-48
Published online on: 01 January 2008

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Article

PP2A activity is controlled by methylation and regulates oncoprotein expression in melanoma cells: A mechanism which participates in growth inhibition induced by chloroethylnitrosourea treatment

Samuel Guénin, Laurent Schwartz, Daniel Morvan, Jean Marc Steyaert, Amandine Poignet, Jean Claude Madelmont, Aicha Demidem
Pages: 49-57
Published online on: 01 January 2008

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Article

A new subtype-specific monoclonal antibody for IAP-survivin identifies high-risk patients with diffuse large B-cell lymphoma and improves the prognostic value of bcl-2

Tryfonia Mainou-Fowler, Lynn Marie Overman, Helen Dignum, Katrina Wood, Stephen Crosier, Brian Angus, Stephen John Proctor, John J. Anderson
Pages: 59-68
Published online on: 01 January 2008

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Article

Measurement of hypoxia using invasive oxygen-sensitive electrode, pimonidazole binding and 18F-FDG uptake in anaemic or erythropoietin-treated mice bearing human glioma xenografts

Sonia Scigliano, Sophie Pinel, Sylvain Poussier, Fanny Fouyssac, Francois Plenat, Gilles Karcher, Pascal Chastagner
Pages: 69-77
Published online on: 01 January 2008

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Article

Mechanism of cell death induced by spermine and amine oxidase in mouse melanoma cells

Diana A. Averill-Bates, Qixiang Ke, André Tanel, Julie Roy, Guy Fortier, Enzo Agostinelli
Pages: 79-88
Published online on: 01 January 2008

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Article

Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin

Sun Young Kim, Hwang Phill Kim, Yu Jung Kim, Do Youn Oh, Seock-Ah Im, Dongsoon Lee, Hyun-Soon Jong, Tae-You Kim, Yung-Jue Bang
Pages: 89-95
Published online on: 01 January 2008

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Article

The novel phenylester anticancer compounds: Study of a derivative of aspirin (phoshoaspirin)

Basil Rigas, Vasiliki Kozoni
Pages: 97-100
Published online on: 01 January 2008

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Article

Oncogenic mutations of the PIK3CA gene in head and neck squamous cell carcinomas

Avaniyapuram Kannan Murugan, Nguyen Thi Hong, Yasuhisa Fukui, Arasambattu Kannan Munirajan, Nobuo Tsuchida
Pages: 101-111
Published online on: 01 January 2008

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Article

Sequence-dependent synergism and antagonism between paclitaxel and gemcitabine in breast cancer cells: The importance of scheduling

Cristina Oliveras-Ferraros, Alejandro Vazquez-Martin, Ramon Colomer, Rafael De Llorens, Joan Brunet, Javier A. Menendez
Pages: 113-120
Published online on: 01 January 2008

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Article

GSH loss per se does not affect neuroblastoma survival and is not genotoxic

Barbara Marengo, Emanuela Balbis, Stefania Patriarca, Chiara De Ciucis, Annalisa Furfaro, Mariapaola Nitti, Umberto Maria Marinari, Maria Adelaide Pronzato, Nicola Traverso, Cinzia Domenicotti
Pages: 121-127
Published online on: 01 January 2008

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Article

Positive expressions of N-acetylglucosaminyltransferase-V (GnT-V) and β1-6 branching N-linked oligosaccharides in human testicular germ cells diminish during malignant transformation and progression

Atsushi Kyan, Noritaka Kamimura, Shigeru Hagisawa, Shingo Hatakeyama, Takuya Koie, Takahiro Yoneyama, Yoichi Arai, Hiroaki Nakagawa, Shin-Ichiro Nishimura, Eiji Miyoshi, Yasuhiro Hashimoto, Chikara Ohyama
Pages: 129-134
Published online on: 01 January 2008

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Article

Bap29varP, a variant of Bap29, influences the cell surface expression of the human P-glycoprotein

Prema S. Rao, Ulrich Bickel, Kalkunte S. Srivenugopal, U. Subrahmanyeswara Rao
Pages: 135-144
Published online on: 01 January 2008

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Article

The effect of hypoxic microenvironment on matrix metalloproteinase expression in xenografts of human oral squamous cell carcinoma

Yasuo Miyazaki, Akira Hara, Keizo Kato, Takeru Oyama, Yasuhiro Yamada, Hideki Mori, Toshiyuki Shibata
Pages: 145-151
Published online on: 01 January 2008

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Article

Liver metastasis models of colon cancer for evaluation of drug efficacy using NOD/Shi-scid IL2Rγnull (NOG) mice

Kenji Hamada, Makoto Monnai, Kenji Kawai, Chiyoko Nishime, Chika Kito, Noriyuki Miyazaki, Yasuyuki Ohnishi, Masato Nakamura, Hiroshi Suemizu
Pages: 153-159
Published online on: 01 January 2008

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Article

Role of alternative splicing of periostin in human bladder carcinogenesis

Chul Jang Kim, Takahiro Isono, Yukihiro Tambe, Tokuhiro Chano, Hidetoshi Okabe, Yusaku Okada, Hirokazu Inoue
Pages: 161-169
Published online on: 01 January 2008

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Article

Topotecan and small interfering RNA suppress survivin expression synergistically in Caki-1 renal cancer cells: Direct suppression of survivin and enhancement of transfection efficiency by topotecan

Akinori Sato, Keiichi Ito, Takako Asano, Makoto Sumitomo, Tomohiko Asano, Masamichi Hayakawa
Pages: 171-176
Published online on: 01 January 2008

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Article

Histone deacetylase inhibitors induce in human hepatoma HepG2 cells acetylation of p53 and histones in correlation with apoptotic effects

D. Carlisi, B. Vassallo, M. Lauricella, S. Emanuele, A. D'Anneo, E. Di Leonardo, P. Di Fazio, R. Vento, G. Tesoriere
Pages: 177-184
Published online on: 01 January 2008

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Article

suPAR, a soluble form of urokinase plasminogen activator receptor, inhibits human prostate cancer cell growth and invasion

M. Piccolella, C. Festuccia, D. Millimaggi, A. Locatelli, M. Bologna, M. Motta, D. Dondi
Pages: 185-191
Published online on: 01 January 2008

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Article

Different tumoricidal effects of interferon subclasses and p53 status on hepatocellular carcinoma development and neovascularization

Ryuichi Noguchi, Hitoshi Yoshiji, Yasuhide Ikenaka, Mitsuteru Kitade, Kosuke Kaji, Junichi Yoshi, Koji Yanase, Tadashi Namisaki, Masaharu Yamazaki, Tatsuhiro Tsujimoto, Takemi Akahane, Masahito Uemura, Hiroshi Fukui
Pages: 193-199
Published online on: 01 January 2008

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Article

Thymidylate synthase polymorphisms and mRNA expression are independent chemotherapy predictive markers in esophageal adenocarcinoma patients

Hidekazu Kuramochi, Koji Tanaka, Daniel Oh, Bethany J. Lehman, Christy M. Dunst, Dong Yun Yang, Steven R. De Meester, Jeffery A. Hagen, Kathleen D. Danenberg, Tom R. De Meester, Peter V. Danenberg
Pages: 201-208
Published online on: 01 January 2008

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Article

Ethanolic extracts of herbal supplement Equiguard™ suppress growth and control gene expression in CWR22Rv1 cells representing the transition of prostate cancer from androgen dependence to hormone refractory status

Tze-Chen Hsieh, Joseph M. Wu
Pages: 209-219
Published online on: 01 January 2008

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Article

The oncofetal protein, 5T4, is a suitable target for antibody-guided anti-cancer chemotherapy with calicheamicin

E. R. Boghaert, L. Sridharan, K. M. Khandke, D. Armellino, M. G. Ryan, K. Myers, R. Harrop, A. Kunz, P. R. Hamann, K. Marquette, M. Dougher, J. F. DiJoseph, N. K. Damle
Pages: 221-234
Published online on: 01 January 2008

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Article

Keratoepithelin reverts the suppression of tissue factor pathway inhibitor 2 by MYCN in human neuroblastoma: A mechanism to inhibit invasion

Juergen Becker, Sonja Volland, Ievgeniia Noskova, Alexander Schramm, Lothar L. Schweigerer, Joerg Wilting
Pages: 235-240
Published online on: 01 January 2008

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Article

Mucosal vaccination with phage-displayed tumour antigens identified through proteomics-based strategy inhibits the growth and metastasis of 4T1 breast adenocarcinoma

Mohsen Shadidi, Dag Sørensen, Anne Dybwad, Gro Furset, Mouldy Sioud
Pages: 241-247
Published online on: 01 January 2008

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Article

Ciglitazone, an agonist of peroxisome proliferator-activated receptor γ, exerts potentiated cytostatic/cytotoxic effects against tumor cells when combined with lovastatin

Piotr Mrówka, Eliza Glodkowska, Dominika Nowis, Magdalena Legat, Tadeusz Issat, Marcin Makowski, Angelika Szokalska, Sylwia Janowska, Tomasz Stoklosa, Marek Jakóbisiak, Jakub Golab
Pages: 249-255
Published online on: 01 January 2008

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Article

Inhibition of NF-κB by (E)3-[(4-methylphenyl)-sulfonyl]-2-propenenitrile (BAY11-7082; BAY) is associated with enhanced 12-O-tetradecanoylphorbol-13-acetate-induced growth suppression and apoptosis in human prostate cancer PC-3 cells

Xi Zheng, Richard L. Chang, Xiao-Xing Cui, Gina Avila, Mou-Tuan Huang, Yue Liu, Ah Ng Tony Kong, Arnold B. Rabson, Allan H. Conney
Pages: 257-264
Published online on: 01 January 2008

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Article

Live cell vaccines expressing B7.1, monocyte chemoattractant protein 1 and granulocyte-macrophage colony stimulation factor derived from mouse HPV16-transformed cells

Monika Lakatosová-Andelová, Pavel Jinoch, Martina Dusková, Iuri Marinov, Vladimír Vonka
Pages: 265-271
Published online on: 01 January 2008

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Article

Characterisation of a novel matrix metalloproteinase inhibitor on pancreatic adenocarcinoma cells in vitro and in an orthotopic pancreatic cancer model in vivo

Matthias Kapischke, Tim Fischer, Katrin Tiessen, Harald Tschesche, Hans-Peter Bruch, Holger Kalthoff, Marie-Luise Kruse
Pages: 273-282
Published online on: 01 January 2008

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Journal Cover
January-2026 Volume 68 Issue 1

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Article Open Access

c‑Myc‑regulated RPLP0 via the ROS‑mediated JAK2/STAT3 positive feedback loop facilitates hepatocellular carcinoma malignancy progression

Yanqiu Meng, Lebin Yuan, Gangrui Meng, Hongxiang Huang, Xianbin Huang, Xinping Xu, Xiaodong Peng
Article Number: 13
Published online on: 27 November 2025

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Review Open Access

Obesity, chronic breast inflammation and carcinogenesis: Molecular pathways and clinical implications (Review)

Fangying Li, Zhenhua Gao
Article Number: 12
Published online on: 27 November 2025

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Review Open Access

The tumor microenvironment in lung cancer: Heterogeneity, therapeutic resistance and emerging treatment strategies (Review)

Li Liu, Li Yang, Hongmin Li, Tianlu Shang, Lihan Liu
Article Number: 11
Published online on: 26 November 2025

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Article Open Access

Discovery of the late autophagy inhibitor FZU‑0045‑053 and its anti‑breast cancer and immunomodulatory effects

Jinlan Luo, Yi Yang, Lulu Cheng, Fangting Cheng, Huangwenlong Zhuang, Shanshan Chen, Panpan Qiao, Yinbin Liang, Li Chen, Yang Sun, Haijun Chen, Qinying Liu
Article Number: 10
Published online on: 26 November 2025

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Correction Open Access

[Corrigendum] RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling

Zi-Hao Qi, Hua-Xiang Xu, Shi-Rong Zhang, Jin-Zhi Xu, Shuo Li, He-Li Gao, Wei Jin, Wen-Quan Wang, Chun-Tao Wu, Quan-Xing Ni, Xian-Jun Yu, Liang Liu
Article Number: 9
Published online on: 24 November 2025

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Article Open Access

Ephrin‑B2 promotes gastric cancer growth by inhibiting apoptosis and regulating the cell cycle via the Wnt/β‑catenin signaling pathway

Ding Ding, Xiaoshan Wang, Ran Xuan, Rui Li, Yalu Zhang, Zhengguang Wang
Article Number: 8
Published online on: 18 November 2025

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Expression of Concern Open Access

[Expression of Concern] Gene therapy for human colorectal cancer cell lines with recombinant adenovirus 5 based on loss of the insulin‑like growth factor 2 imprinting

Huiling Sun, Yuqin Pan, Bangshun He, Qiwen Deng, Rui Li, Yeqiong Xu, Jie Chen, Tianyi Gao, Houqun Ying, Feng Wang, Xian Liu, Shukui Wang
Article Number: 7
Published online on: 18 November 2025

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Review Open Access

Ferroptosis in biliary tract cancer: Molecular mechanisms and therapeutic applications (Review)

Ruiqi Zou, Yushi Dai, Siqi Yang, Haijie Hu, Fuyu Li, Fei Liu
Article Number: 6
Published online on: 14 November 2025

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Expression of Concern Open Access

[Expression of Concern] Radiosensitization of esophageal carcinoma cells by knockdown of RNF2 expression

Xing-Xiao Yang, Ming Ma, Mei-Xiang Sang, Xue-Xiao Wang, Heng Song, Zhi-Kun Liu, Shu-Chai Zhu
Article Number: 5
Published online on: 10 November 2025

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Review Open Access

Targeting ferroptosis in Helicobacter pylori‑associated gastric cancer development: From molecular mechanisms to application prospects (Review)

Chen-Yi Wang, Meng-Hui Wang, Chuan Xie
Article Number: 4
Published online on: 05 November 2025

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Expression of Concern Open Access

[Expression of Concern] Leptin promotes breast cancer cell migration and invasion via IL‑18 expression and secretion

Kuangfa Li, Lan Wei, Yunxiu Huang, Yang Wu, Min Su, Xueli Pang, Nian Wang, Feihu Ji, Changli Zhong, Tingmei Chen
Article Number: 3
Published online on: 04 November 2025

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Review Open Access

Cancer immunotherapy strategies based on transition‑metal medical materials: Still a long way to go (Review)

Zhefei Du, Zhenyu Cao, Chao Fang, Daihan Xie, Lixin Xie, Chunxia Su, Yu Huo
Article Number: 2
Published online on: 04 November 2025

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Expression of Concern Open Access

[Expression of Concern] Regulation of NADPH oxidase (Nox2) by lipid rafts in breast carcinoma cells

Rama Rao Malla, Hari Raghu, Jasti S. Rao
Article Number: 1
Published online on: 23 October 2025

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Journal Cover
February-2026 Volume 68 Issue 2

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Retraction Open Access

[Retracted] Cdc42 expression in cervical cancer and its effects on cervical tumor invasion and migration

Hongnan Ye, Youyi Zhang, Li Geng, Zijian Li
Article Number: 20
Published online on: 05 December 2025

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Article Open Access

Regulation and reversal of paclitaxel resistance via the STAT1‑mediated apoptotic pathway in ovarian cancer

Fanchen Wang, Xiaolin Xu, Bin Guan, Xin Li, Jia Yuan, Wencai Guan, Junyu Chen, Jingyi Fang, Qi Lu, Guoxiong Xu
Article Number: 19
Published online on: 05 December 2025

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Review

Cancer stem cell heterogeneity‑inspired therapeutics for enhancing tumor treatment outcomes (Review)

Hanning Xu, Qunchao Si, Yongyao Song, Shengping Sun, Xianghong Wei, Hui Long, Xiaomei Wang
Article Number: 18
Published online on: 04 December 2025

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Review Open Access

Roles of interleukins in spasmolytic polypeptide‑expressing metaplasia (Review)

Jiale Ma, Tiancheng Zhan, Xinyuan Zhang, Wang Gao, Shuangmei Zhao, Huizhen Li
Article Number: 17
Published online on: 03 December 2025

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Expression of Concern Open Access

[Expression of Concern] MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion

Jingchun Gao, Matthew J. Mcconnell, Bin Yu, Jiannong Li, Justin M. Balko, Esther P. Black, Joseph O. Johnson, Mark C. Lloyd, Soner Altiok, Eric B. Haura
Article Number: 16
Published online on: 03 December 2025

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Review Open Access

Emerging biomarkers in prostate cancer diagnosis and treatment: Insights into genetic, RNA and metabolic markers (Review)

Yuanshe Huang, Jingxin Mao, Xiaobing Li
Article Number: 15
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] GDC‑0152 attenuates the malignant progression of osteosarcoma promoted by ANGPTL2 via PI3K/AKT but not p38MAPK signaling pathway

Lin Yang, Taipengfei Shu, Yingjian Liang, Wenguang Gu, Chunlei Wang, Xuanhe Song, Changdong Fan, Wenbo Wang
Article Number: 14
Published online on: 01 December 2025

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