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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2008 Volume 32 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2008 Volume 32 Issue 1

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Article

Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin

  • Authors:
    • Sun Young Kim
    • Hwang Phill Kim
    • Yu Jung Kim
    • Do Youn Oh
    • Seock-Ah Im
    • Dongsoon Lee
    • Hyun-Soon Jong
    • Tae-You Kim
    • Yung-Jue Bang

  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Seoul National University College of Medicine, Chongro-gu, Seoul 110-799, Korea
  • Pages: 89-95
    |
    Published online on: January 1, 2008
       https://doi.org/10.3892/ijo.32.1.89
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Abstract

HER2 has been found to be amplified in 10-20% of gastric cancers, and is correlated with poor outcome. The aims of this study were to recognize HER2 amplification in gastric cancer cell lines via fluorescence in situ hybridization and to evaluate the growth inhibitory effect of trastuzumab in HER2-amplified cell lines. To elucidate the mechanism of the growth inhibition, we performed cell cycle analysis and immunoblotting of downstream molecules. We also conducted drug interaction studies of trastuzumab with other chemothera-peutic agents. HER2 amplification was newly identified only in SNU-216 cells, and trastuzumab moderately inhibited the growth of SNU-216 cells and positive controls. Trastuzumab-mediated G1 arrest occurred with increased expression of p27KIP1 and decreased cyclins. Phosphorylation of HER2 and downstream molecules, STAT3, AKT, and ERK, was also inhibited by trastuzumab. Treatment of SNU-216 cells with trastuzumab plus cisplatin resulted in a synergistic inhibitory effect, whereas treatment of SNU-216 cells with trastuzumab plus 5-FU, or trastuzumab plus oxaliplatin produced an additive effect. These results suggest that trastuzumab combined with chemotherapeutic agents can be active against gastric cancer with HER2 amplification.

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Copy and paste a formatted citation
Spandidos Publications style
Kim SY, Kim HP, Kim YJ, Oh DY, Im S, Lee D, Jong H, Kim T and Bang Y: Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin. Int J Oncol 32: 89-95, 2008.
APA
Kim, S.Y., Kim, H.P., Kim, Y.J., Oh, D.Y., Im, S., Lee, D. ... Bang, Y. (2008). Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin. International Journal of Oncology, 32, 89-95. https://doi.org/10.3892/ijo.32.1.89
MLA
Kim, S. Y., Kim, H. P., Kim, Y. J., Oh, D. Y., Im, S., Lee, D., Jong, H., Kim, T., Bang, Y."Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin". International Journal of Oncology 32.1 (2008): 89-95.
Chicago
Kim, S. Y., Kim, H. P., Kim, Y. J., Oh, D. Y., Im, S., Lee, D., Jong, H., Kim, T., Bang, Y."Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin". International Journal of Oncology 32, no. 1 (2008): 89-95. https://doi.org/10.3892/ijo.32.1.89
Copy and paste a formatted citation
x
Spandidos Publications style
Kim SY, Kim HP, Kim YJ, Oh DY, Im S, Lee D, Jong H, Kim T and Bang Y: Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin. Int J Oncol 32: 89-95, 2008.
APA
Kim, S.Y., Kim, H.P., Kim, Y.J., Oh, D.Y., Im, S., Lee, D. ... Bang, Y. (2008). Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin. International Journal of Oncology, 32, 89-95. https://doi.org/10.3892/ijo.32.1.89
MLA
Kim, S. Y., Kim, H. P., Kim, Y. J., Oh, D. Y., Im, S., Lee, D., Jong, H., Kim, T., Bang, Y."Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin". International Journal of Oncology 32.1 (2008): 89-95.
Chicago
Kim, S. Y., Kim, H. P., Kim, Y. J., Oh, D. Y., Im, S., Lee, D., Jong, H., Kim, T., Bang, Y."Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin". International Journal of Oncology 32, no. 1 (2008): 89-95. https://doi.org/10.3892/ijo.32.1.89
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