The novel phenylester anticancer compounds: Study of a derivative of aspirin (phoshoaspirin)

  • Authors:
    • Basil Rigas
    • Vasiliki Kozoni
  • View Affiliations

  • Published online on: January 1, 2008     https://doi.org/10.3892/ijo.32.1.97
  • Pages: 97-100
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

We have synthesized a series of novel phenylester compounds and present our assessment of such a derivative of aspirin, 3-((diethoxyphosphoryloxy)methyl)phenyl 2-acetoxybenzoate, provisionally named phosphoaspirin. We determined its anticancer activity both in vitro and in vivo. Phosphoaspirin inhibited the growth of HT-29 human colon adenocarcinoma cells (IC50 = 276.6±12.3 µM (mean ± SEM)] through a combined antiproliferative and mainly proapoptotic effect. Phosphoaspirin (100 mg/kg body weight intraperitoneally daily for 21 days) also inhibited the growth of HT-29 tumors grown as xenografts in nude mice. The size of the tumors decreased progressively in the phosphoaspirin treated group, compared to controls, being reduced by 57% (p<0.001) on day 21. Phosphoaspirin achieved this effect by modulating cell kinetics; the proliferation index of cancer cells was reduced by 18.13% compared to controls (p<0.001) and the apoptosis index was increased by 94.6% (p<0.003). There was no apparent toxicity from phosphoaspirin. We conclude that phosphoaspirin is a promising agent for the control of cancer that deserves further evaluation.

Related Articles

Journal Cover

January 2008
Volume 32 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Rigas B and Rigas B: The novel phenylester anticancer compounds: Study of a derivative of aspirin (phoshoaspirin). Int J Oncol 32: 97-100, 2008
APA
Rigas, B., & Rigas, B. (2008). The novel phenylester anticancer compounds: Study of a derivative of aspirin (phoshoaspirin). International Journal of Oncology, 32, 97-100. https://doi.org/10.3892/ijo.32.1.97
MLA
Rigas, B., Kozoni, V."The novel phenylester anticancer compounds: Study of a derivative of aspirin (phoshoaspirin)". International Journal of Oncology 32.1 (2008): 97-100.
Chicago
Rigas, B., Kozoni, V."The novel phenylester anticancer compounds: Study of a derivative of aspirin (phoshoaspirin)". International Journal of Oncology 32, no. 1 (2008): 97-100. https://doi.org/10.3892/ijo.32.1.97