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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2008 Volume 32 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2008 Volume 32 Issue 4

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Article

Gene alterations by peroxisome proliferator-activated receptor γ agonists in human colorectal cancer cells

  • Authors:
    • Maria Cekanova
    • Joshua S. Yuan
    • Xiuoon Li
    • Kyubo Kim
    • Seung Joon Baek

  • View Affiliations / Copyright

    Affiliations: Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN 37996, USA
  • Pages: 809-819
    |
    Published online on: April 1, 2008
       https://doi.org/10.3892/ijo.32.4.809
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Abstract

The peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear transcription factor that controls the genes involved in metabolism and carcinogenesis. In the present study, we examined the alteration of gene expression in HCT-116 human colorectal cancer cells by PPARγ agonists: MCC-555 (5 µM), rosiglitazone (5 µM), and 15-deoxy-Δ12,14-prostaglandin J2 (1 µM). The long-oligo microarray data revealed a list of target genes commonly induced (307 genes) and repressed (32 genes) by tested PPARγ agonists. These genes were analyzed by Onto-Express software and KEGG pathway analysis and revealed that PPARγ agonists are involved in cell proliferation, focal adhesion, and several signaling pathways. Eight genes were selected to confirm the microarray data by RT-PCR and real-time PCR, from which CSTA, DAP13, TAF12, RIS1, CDKN3 and MAGOH were up-regulated, and KLHL11 and NCOA2 were down-regulated. This study elucidates the commonly induced genes modulated by tested PPARγ ligands involved in the different signaling pathways and metabolisms, probably mediated in a PPARγ-dependent manner in colorectal cancer cells and helps to better understand the pleiotropic actions of PPARγ ligands.

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Copy and paste a formatted citation
Spandidos Publications style
Cekanova M, Yuan JS, Li X, Kim K and Baek SJ: Gene alterations by peroxisome proliferator-activated receptor γ agonists in human colorectal cancer cells. Int J Oncol 32: 809-819, 2008.
APA
Cekanova, M., Yuan, J.S., Li, X., Kim, K., & Baek, S.J. (2008). Gene alterations by peroxisome proliferator-activated receptor γ agonists in human colorectal cancer cells. International Journal of Oncology, 32, 809-819. https://doi.org/10.3892/ijo.32.4.809
MLA
Cekanova, M., Yuan, J. S., Li, X., Kim, K., Baek, S. J."Gene alterations by peroxisome proliferator-activated receptor γ agonists in human colorectal cancer cells". International Journal of Oncology 32.4 (2008): 809-819.
Chicago
Cekanova, M., Yuan, J. S., Li, X., Kim, K., Baek, S. J."Gene alterations by peroxisome proliferator-activated receptor γ agonists in human colorectal cancer cells". International Journal of Oncology 32, no. 4 (2008): 809-819. https://doi.org/10.3892/ijo.32.4.809
Copy and paste a formatted citation
x
Spandidos Publications style
Cekanova M, Yuan JS, Li X, Kim K and Baek SJ: Gene alterations by peroxisome proliferator-activated receptor γ agonists in human colorectal cancer cells. Int J Oncol 32: 809-819, 2008.
APA
Cekanova, M., Yuan, J.S., Li, X., Kim, K., & Baek, S.J. (2008). Gene alterations by peroxisome proliferator-activated receptor γ agonists in human colorectal cancer cells. International Journal of Oncology, 32, 809-819. https://doi.org/10.3892/ijo.32.4.809
MLA
Cekanova, M., Yuan, J. S., Li, X., Kim, K., Baek, S. J."Gene alterations by peroxisome proliferator-activated receptor γ agonists in human colorectal cancer cells". International Journal of Oncology 32.4 (2008): 809-819.
Chicago
Cekanova, M., Yuan, J. S., Li, X., Kim, K., Baek, S. J."Gene alterations by peroxisome proliferator-activated receptor γ agonists in human colorectal cancer cells". International Journal of Oncology 32, no. 4 (2008): 809-819. https://doi.org/10.3892/ijo.32.4.809
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