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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2008 Volume 32 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2008 Volume 32 Issue 5

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Article

Detection of a hypersialylated β1 integrin endogenously expressed in the human astrocytoma cell line A172

  • Authors:
    • Petr Bartik
    • Anne Maglott
    • Gustav Entlicher
    • Dietmar Vestweber
    • Ken Takeda
    • Sophie Martin
    • Monique Dontenwill

  • View Affiliations / Copyright

    Affiliations: Département de Pharmacologie et Physicochimie, UMR 7175 CNRS, Université Louis Pasteur - Strasbourg I, Faculté de Pharmacie, BP 60024, 67401 Illkirch, France
  • Pages: 1021-1031
    |
    Published online on: May 1, 2008
       https://doi.org/10.3892/ijo.32.5.1021
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Abstract

Gliomas are the most common deadly brain tumors. Human cerebral tumors express high level of α5β1 integrins. As a potential new target, α5β1 was investigated here in two human astrocytoma cell lines, A172 and U87MG. We found that a hypersialylated β1 integrin was endogenously expressed in A172 cells. It forms heterodimers with α5 subunits, localizes at the cell membrane and allows adhesion to fibronectin. This form of β1 integrin was only recognized by the 9EG7 anti-β1 antibody and appeared devoid of other specific antibody epitopes (12G10, TS2/16 and mAb13 shown here to be N-glycosylation sensitive). Overexpression of the β1 integrin subunit in A172 cells not only increased the hypersialylated form but also led to the appearance of a non-hypersialylated β1 form also addressed to the cell surface. Compared to wild-type A172 cells, β1-A172 cells showed increased adhesion to fibronectin and decreased sensitivity to SJ749, a non-peptidic α5β1 antagonist. In addition, β1-A172 cells exhibited increased matrix dependence for normal cell cycling. Collectively, the data add new evidence for the role of β1 glycosylation/sialylation in the regulation of integrin functions.

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Copy and paste a formatted citation
Spandidos Publications style
Bartik P, Maglott A, Entlicher G, Vestweber D, Takeda K, Martin S and Dontenwill M: Detection of a hypersialylated β1 integrin endogenously expressed in the human astrocytoma cell line A172. Int J Oncol 32: 1021-1031, 2008.
APA
Bartik, P., Maglott, A., Entlicher, G., Vestweber, D., Takeda, K., Martin, S., & Dontenwill, M. (2008). Detection of a hypersialylated β1 integrin endogenously expressed in the human astrocytoma cell line A172. International Journal of Oncology, 32, 1021-1031. https://doi.org/10.3892/ijo.32.5.1021
MLA
Bartik, P., Maglott, A., Entlicher, G., Vestweber, D., Takeda, K., Martin, S., Dontenwill, M."Detection of a hypersialylated β1 integrin endogenously expressed in the human astrocytoma cell line A172". International Journal of Oncology 32.5 (2008): 1021-1031.
Chicago
Bartik, P., Maglott, A., Entlicher, G., Vestweber, D., Takeda, K., Martin, S., Dontenwill, M."Detection of a hypersialylated β1 integrin endogenously expressed in the human astrocytoma cell line A172". International Journal of Oncology 32, no. 5 (2008): 1021-1031. https://doi.org/10.3892/ijo.32.5.1021
Copy and paste a formatted citation
x
Spandidos Publications style
Bartik P, Maglott A, Entlicher G, Vestweber D, Takeda K, Martin S and Dontenwill M: Detection of a hypersialylated β1 integrin endogenously expressed in the human astrocytoma cell line A172. Int J Oncol 32: 1021-1031, 2008.
APA
Bartik, P., Maglott, A., Entlicher, G., Vestweber, D., Takeda, K., Martin, S., & Dontenwill, M. (2008). Detection of a hypersialylated β1 integrin endogenously expressed in the human astrocytoma cell line A172. International Journal of Oncology, 32, 1021-1031. https://doi.org/10.3892/ijo.32.5.1021
MLA
Bartik, P., Maglott, A., Entlicher, G., Vestweber, D., Takeda, K., Martin, S., Dontenwill, M."Detection of a hypersialylated β1 integrin endogenously expressed in the human astrocytoma cell line A172". International Journal of Oncology 32.5 (2008): 1021-1031.
Chicago
Bartik, P., Maglott, A., Entlicher, G., Vestweber, D., Takeda, K., Martin, S., Dontenwill, M."Detection of a hypersialylated β1 integrin endogenously expressed in the human astrocytoma cell line A172". International Journal of Oncology 32, no. 5 (2008): 1021-1031. https://doi.org/10.3892/ijo.32.5.1021
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