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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2008 Volume 32 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2008 Volume 32 Issue 5

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Article

Silencing of ZNF217 gene influences the biological behavior of a human ovarian cancer cell line

  • Authors:
    • Guiqin Sun
    • Jun Zhou
    • Ailan Yin
    • Yanqing Ding
    • Mei Zhong

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, P.R. China
  • Pages: 1065-1071
    |
    Published online on: May 1, 2008
       https://doi.org/10.3892/ijo.32.5.1065
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Abstract

Zinc-finger protein 217 (ZNF217), a candidate oncogene on 20q13.2, can lead cultured human ovarian and mammary epithelial cells to immortalization, which indicates selective expression of ZNF217 affecting 20q13 amplification during critical early stages of cancer progression. In this study, we tested the hypothesis that ZNF217 is a key factor in regulating ovarian cancer proliferation and progression. We examined the effect of the inhibition of ZNF217 expression on proliferation and invasion by establishing the ZNF217 knockdown ovarian cancer cell line using RNA interference (RNAi). Our results showed that silencing of ZNF217 resulted in the effective inhibition of ovarian cancer cell growth and invasive ability. The results suggested that ZNF217 might play a crucial role in the proliferation and invasion of ovarian cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Sun G, Zhou J, Yin A, Ding Y and Zhong M: Silencing of ZNF217 gene influences the biological behavior of a human ovarian cancer cell line. Int J Oncol 32: 1065-1071, 2008.
APA
Sun, G., Zhou, J., Yin, A., Ding, Y., & Zhong, M. (2008). Silencing of ZNF217 gene influences the biological behavior of a human ovarian cancer cell line. International Journal of Oncology, 32, 1065-1071. https://doi.org/10.3892/ijo.32.5.1065
MLA
Sun, G., Zhou, J., Yin, A., Ding, Y., Zhong, M."Silencing of ZNF217 gene influences the biological behavior of a human ovarian cancer cell line". International Journal of Oncology 32.5 (2008): 1065-1071.
Chicago
Sun, G., Zhou, J., Yin, A., Ding, Y., Zhong, M."Silencing of ZNF217 gene influences the biological behavior of a human ovarian cancer cell line". International Journal of Oncology 32, no. 5 (2008): 1065-1071. https://doi.org/10.3892/ijo.32.5.1065
Copy and paste a formatted citation
x
Spandidos Publications style
Sun G, Zhou J, Yin A, Ding Y and Zhong M: Silencing of ZNF217 gene influences the biological behavior of a human ovarian cancer cell line. Int J Oncol 32: 1065-1071, 2008.
APA
Sun, G., Zhou, J., Yin, A., Ding, Y., & Zhong, M. (2008). Silencing of ZNF217 gene influences the biological behavior of a human ovarian cancer cell line. International Journal of Oncology, 32, 1065-1071. https://doi.org/10.3892/ijo.32.5.1065
MLA
Sun, G., Zhou, J., Yin, A., Ding, Y., Zhong, M."Silencing of ZNF217 gene influences the biological behavior of a human ovarian cancer cell line". International Journal of Oncology 32.5 (2008): 1065-1071.
Chicago
Sun, G., Zhou, J., Yin, A., Ding, Y., Zhong, M."Silencing of ZNF217 gene influences the biological behavior of a human ovarian cancer cell line". International Journal of Oncology 32, no. 5 (2008): 1065-1071. https://doi.org/10.3892/ijo.32.5.1065
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