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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2008 Volume 32 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2008 Volume 32 Issue 5

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Article

MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice

  • Authors:
    • Lieselot De Vos
    • Jeroen Declercq
    • Georgina Galicia Rosas
    • Boudewijn Van Damme
    • Anton Roebroek
    • Fons Vermorken
    • Jan Ceuppens
    • Wim van de Ven
    • John Creemers

  • View Affiliations

    Affiliations: Laboratory for Molecular Oncology, Department of Human Genetics, Department of Human Genetics, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium
  • Published online on: May 1, 2008     https://doi.org/10.3892/ijo.32.5.1073
  • Pages: 1073-1083
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Abstract

Proprotein convertases are serine endoproteases implicated in the proteolytic processing of a large variety of regulatory proteins. An important role of proprotein convertases in tumorigenic processes has been suggested by various studies. In this study, the role of the proprotein convertase furin in PLAG1 proto-oncogene-induced salivary gland tumorigenesis was investigated. PLAG1 overexpression in salivary glands has previously been shown to result in salivary gland tumors in 100% of mice within 5 weeks after birth. MMTV-cre-mediated inactivation of fur without over-expression of PLAG1 caused smaller but histologically normal salivary glands. Moreover, the lymph nodes close to the salivary glands were enlarged, and histology showed that they had activated follicles. When genetic ablation of 1 or 2 alleles of fur and overexpression of the PLAG1 transgene were simultaneously achieved, a significant delay in tumorigenesis was observed. Collectively, these results suggest an important role for furin in PLAG1-induced salivary gland tumorigenesis in mice.

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Copy and paste a formatted citation
Spandidos Publications style
De Vos L, Declercq J, Rosas GG, Van Damme B, Roebroek A, Vermorken F, Ceuppens J, van de Ven W and Creemers J: MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice. Int J Oncol 32: 1073-1083, 2008.
APA
De Vos, L., Declercq, J., Rosas, G.G., Van Damme, B., Roebroek, A., Vermorken, F. ... Creemers, J. (2008). MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice. International Journal of Oncology, 32, 1073-1083. https://doi.org/10.3892/ijo.32.5.1073
MLA
De Vos, L., Declercq, J., Rosas, G. G., Van Damme, B., Roebroek, A., Vermorken, F., Ceuppens, J., van de Ven, W., Creemers, J."MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice". International Journal of Oncology 32.5 (2008): 1073-1083.
Chicago
De Vos, L., Declercq, J., Rosas, G. G., Van Damme, B., Roebroek, A., Vermorken, F., Ceuppens, J., van de Ven, W., Creemers, J."MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice". International Journal of Oncology 32, no. 5 (2008): 1073-1083. https://doi.org/10.3892/ijo.32.5.1073
Copy and paste a formatted citation
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Spandidos Publications style
De Vos L, Declercq J, Rosas GG, Van Damme B, Roebroek A, Vermorken F, Ceuppens J, van de Ven W and Creemers J: MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice. Int J Oncol 32: 1073-1083, 2008.
APA
De Vos, L., Declercq, J., Rosas, G.G., Van Damme, B., Roebroek, A., Vermorken, F. ... Creemers, J. (2008). MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice. International Journal of Oncology, 32, 1073-1083. https://doi.org/10.3892/ijo.32.5.1073
MLA
De Vos, L., Declercq, J., Rosas, G. G., Van Damme, B., Roebroek, A., Vermorken, F., Ceuppens, J., van de Ven, W., Creemers, J."MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice". International Journal of Oncology 32.5 (2008): 1073-1083.
Chicago
De Vos, L., Declercq, J., Rosas, G. G., Van Damme, B., Roebroek, A., Vermorken, F., Ceuppens, J., van de Ven, W., Creemers, J."MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice". International Journal of Oncology 32, no. 5 (2008): 1073-1083. https://doi.org/10.3892/ijo.32.5.1073
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