SERUM CATHEPSIN-B LEVELS AND URINARY-EXCRETION OF CATHEPSIN-B IN THE PATIENTS WITH COLORECTAL-CANCER - POSSIBLE INDICATORS FOR TUMOR MALIGNANCY
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- Published online on: January 1, 1994 https://doi.org/10.3892/ijo.4.1.151
- Pages: 151-153
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Abstract
Serum cathepsin B levels and urinary excretion of cathepsin B in patients with colorectal cancers were significantly higher than those in the control non-cancer patients. Moreover, cancer tissue cathepsin B content was significantly higher than that in the normal tissue. After radical curative operations for colorectal cancers, both the serum cathepsin B levels and urinary excretion of cathepsin B were restored to the control values. These results suggest a possible role of lysosomal enzyme, cathepsin B, in the pathogenesis of tumor growth, and also suggest that these parameters might be possible indicators for tumor malignancy.
