IMMUNOSTAINING OF CATHEPSIN-D IN NONSMALL CELL LUNG-CANCER - CORRELATIONS WITH MORPHOLOGICAL AND BIOLOGICAL PARAMETERS

  • Authors:
    • G FONTANINI
    • D BIGINI
    • S VIGNATI
    • A RIBECHINI
    • CA ANGELETTI
    • R PINGITORE
  • View Affiliations

  • Published online on: January 1, 1994     https://doi.org/10.3892/ijo.4.1.169
  • Pages: 169-173
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Abstract

Cathepsin D expression has been assessed by immunohistochemistry in 108 cases of Non-Small Cell Lung Cancer (NSCLC) and its expression has been related to conventional prognostic factors such as tumor size, tumor grade, histotype and nodal involvement. The cancer cells in 41.6% of the tumors showed a granular, cytoplasmic cathepsin D (C-D) positivity. Moreover, some benign macrofage-like stromal cells expressed similar positivity. The C-D immunoreactivity was significantly associated with non-squamous histotype, small size, less advanced and more differentiated cancers. Additionally, in non-squamous tumors we observed a higher significant expression in early-staged (T1-2, NO) than in more advanced neoplasias. No significant associations were found between C-D and Ki-67, PCNA immunoreactivity, DNA ploidy or flow cytometric S-phase data. These findings suggest that NSCLCs also express C-D but, as previously reported for breast cancers, the immunohistochemical C-D expression has a good prognostic significance unlike the results obtained by cytosolic evaluation.

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January 1994
Volume 4 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
FONTANINI G, BIGINI D, VIGNATI S, RIBECHINI A, ANGELETTI C and PINGITORE R: IMMUNOSTAINING OF CATHEPSIN-D IN NONSMALL CELL LUNG-CANCER - CORRELATIONS WITH MORPHOLOGICAL AND BIOLOGICAL PARAMETERS. Int J Oncol 4: 169-173, 1994.
APA
FONTANINI, G., BIGINI, D., VIGNATI, S., RIBECHINI, A., ANGELETTI, C., & PINGITORE, R. (1994). IMMUNOSTAINING OF CATHEPSIN-D IN NONSMALL CELL LUNG-CANCER - CORRELATIONS WITH MORPHOLOGICAL AND BIOLOGICAL PARAMETERS. International Journal of Oncology, 4, 169-173. https://doi.org/10.3892/ijo.4.1.169
MLA
FONTANINI, G., BIGINI, D., VIGNATI, S., RIBECHINI, A., ANGELETTI, C., PINGITORE, R."IMMUNOSTAINING OF CATHEPSIN-D IN NONSMALL CELL LUNG-CANCER - CORRELATIONS WITH MORPHOLOGICAL AND BIOLOGICAL PARAMETERS". International Journal of Oncology 4.1 (1994): 169-173.
Chicago
FONTANINI, G., BIGINI, D., VIGNATI, S., RIBECHINI, A., ANGELETTI, C., PINGITORE, R."IMMUNOSTAINING OF CATHEPSIN-D IN NONSMALL CELL LUNG-CANCER - CORRELATIONS WITH MORPHOLOGICAL AND BIOLOGICAL PARAMETERS". International Journal of Oncology 4, no. 1 (1994): 169-173. https://doi.org/10.3892/ijo.4.1.169