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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 1994 Volume 4 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 1994 Volume 4 Issue 2

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Article

ELEVATED PRETREATMENT LEVELS OF SOLUBLE CD8 AND BETA-2-MICROGLOBULIN AS INDICATORS OF RELAPSE IN BREAST-CANCER PATIENTS

  • Authors:
    • B KLEIN
    • I LEVIN
    • H LURIE
    • A NYSKA
    • J SHAPIRA
    • M KRAVITS
    • T KLEIN

  • View Affiliations / Copyright

    Affiliations: SOROKA HOSP,DEPT UROL,BEER SHEVA,ISRAEL. BEILINSON MED CTR,DEPT ONCOL,IL-49100 PETAH TIQWA,ISRAEL. KIMRON VET INST,BET DAGAN,ISRAEL. MEIR HOSP,ONCOL UNIT,KEFAR SAVA,ISRAEL. TEL AVIV UNIV,BEILINSON MED CTR,TISSUE TYPING LAB,TEL AVIV,ISRAEL. TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL.
  • Pages: 471-474
    |
    Published online on: February 1, 1994
       https://doi.org/10.3892/ijo.4.2.471
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Abstract

We measured soluble CD8 ((S)CD8) and microglobulin (beta-2M) in 128 breast cancer patients and in 200 controls by the ELISA method. Patient groups were: Group A-new patients; Group B-patients on follow-up; Group C-patients with metastases. The mean (S)CD8 and beta-2M were significantly higher in patients than in controls ((S)CD8 p<0.01, beta-2M p<0.0001). Both for (S)CD8 and beta-2M, groups A and C had high levels which differed significantly from Group B ((S)CD8 p<0.04; beta-2M p<0.0001). A significant correlation between (S)CD8 and B-2M was observed (r=0.379: p=0.0001). Twenty patients relapsed. In 14/20 (70%) an initial high (S)CD8 and in 10/20 (50%), high beta-2M was observed. High initial CD8 and beta-2M were able to identify 80% of relapsed patients. High (S)CD8 and beta-2M levels are indicative of tumor bulk and are able to identify patients at

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Copy and paste a formatted citation
Spandidos Publications style
KLEIN B, LEVIN I, LURIE H, NYSKA A, SHAPIRA J, KRAVITS M and KLEIN T: ELEVATED PRETREATMENT LEVELS OF SOLUBLE CD8 AND BETA-2-MICROGLOBULIN AS INDICATORS OF RELAPSE IN BREAST-CANCER PATIENTS. Int J Oncol 4: 471-474, 1994.
APA
KLEIN, B., LEVIN, I., LURIE, H., NYSKA, A., SHAPIRA, J., KRAVITS, M., & KLEIN, T. (1994). ELEVATED PRETREATMENT LEVELS OF SOLUBLE CD8 AND BETA-2-MICROGLOBULIN AS INDICATORS OF RELAPSE IN BREAST-CANCER PATIENTS. International Journal of Oncology, 4, 471-474. https://doi.org/10.3892/ijo.4.2.471
MLA
KLEIN, B., LEVIN, I., LURIE, H., NYSKA, A., SHAPIRA, J., KRAVITS, M., KLEIN, T."ELEVATED PRETREATMENT LEVELS OF SOLUBLE CD8 AND BETA-2-MICROGLOBULIN AS INDICATORS OF RELAPSE IN BREAST-CANCER PATIENTS". International Journal of Oncology 4.2 (1994): 471-474.
Chicago
KLEIN, B., LEVIN, I., LURIE, H., NYSKA, A., SHAPIRA, J., KRAVITS, M., KLEIN, T."ELEVATED PRETREATMENT LEVELS OF SOLUBLE CD8 AND BETA-2-MICROGLOBULIN AS INDICATORS OF RELAPSE IN BREAST-CANCER PATIENTS". International Journal of Oncology 4, no. 2 (1994): 471-474. https://doi.org/10.3892/ijo.4.2.471
Copy and paste a formatted citation
x
Spandidos Publications style
KLEIN B, LEVIN I, LURIE H, NYSKA A, SHAPIRA J, KRAVITS M and KLEIN T: ELEVATED PRETREATMENT LEVELS OF SOLUBLE CD8 AND BETA-2-MICROGLOBULIN AS INDICATORS OF RELAPSE IN BREAST-CANCER PATIENTS. Int J Oncol 4: 471-474, 1994.
APA
KLEIN, B., LEVIN, I., LURIE, H., NYSKA, A., SHAPIRA, J., KRAVITS, M., & KLEIN, T. (1994). ELEVATED PRETREATMENT LEVELS OF SOLUBLE CD8 AND BETA-2-MICROGLOBULIN AS INDICATORS OF RELAPSE IN BREAST-CANCER PATIENTS. International Journal of Oncology, 4, 471-474. https://doi.org/10.3892/ijo.4.2.471
MLA
KLEIN, B., LEVIN, I., LURIE, H., NYSKA, A., SHAPIRA, J., KRAVITS, M., KLEIN, T."ELEVATED PRETREATMENT LEVELS OF SOLUBLE CD8 AND BETA-2-MICROGLOBULIN AS INDICATORS OF RELAPSE IN BREAST-CANCER PATIENTS". International Journal of Oncology 4.2 (1994): 471-474.
Chicago
KLEIN, B., LEVIN, I., LURIE, H., NYSKA, A., SHAPIRA, J., KRAVITS, M., KLEIN, T."ELEVATED PRETREATMENT LEVELS OF SOLUBLE CD8 AND BETA-2-MICROGLOBULIN AS INDICATORS OF RELAPSE IN BREAST-CANCER PATIENTS". International Journal of Oncology 4, no. 2 (1994): 471-474. https://doi.org/10.3892/ijo.4.2.471
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