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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 1994 Volume 4 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March 1994 Volume 4 Issue 3

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Article

RAS P21 OVEREXPRESSION IS A LATE EVENT IN PROSTATE-CANCER

  • Authors:
    • SM HAMDY
    • AG APRIKIAN
    • LR BEGIN
    • WR FAIR
    • M BAZINET

  • View Affiliations / Copyright

    Affiliations: MCGILL UNIV,MONTREAL GEN HOSP,DEPT UROL,1650 CEDAR,MONTREAL H3G 1A4,QUEBEC,CANADA. MCGILL UNIV,MONTREAL GEN HOSP,DEPT PATHOL,MONTREAL H3G 1A4,QUEBEC,CANADA. MEM SLOAN KETTERING CANC CTR,UROL SERV,NEW YORK,NY 10021.
  • Pages: 627-631
    |
    Published online on: March 1, 1994
       https://doi.org/10.3892/ijo.4.3.627
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Abstract

Several lines of evidence implicate the ras oncogene in tumorigenesis. However, changes in ras oncogene is uncommon in prostate cancer. We evaluated tumors from 55 patients with metastatic prostate cancer (50 lymph nodes, 5 bone metastases), 10 patients with localized cancers and 35 diethylstilbestrol treated primary tumors. Also, 15 patients with benign prostatic hyperplasia and 23 with prostatic intraepithelial neoplasia (PIN) were investigated for ras p21 expression. Avidin biotin immunoperoxidase was used on formalin-fixed, paraffin-embedded tissues with the Pan-ras (Ab-1) monoclonal antibody. Antibody titration demonstrated expression of ras p21 in none of the benign, PIN or DES-treated primary tumor specimens. However, 30% of untreated primary tumors and 94.5% of metastatic tumors (94% of lymph node metastases, 100% of bone metastases) showed expression (p=0.00002). Semi-quantitative evaluation of ras protein expression revealed a significant correlation with Gleason score in lymph node metastases (p=0.001). This study suggests a possible role of ras oncogene in prostate cancer progression, metastasis and androgen independency.

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Copy and paste a formatted citation
Spandidos Publications style
HAMDY S, APRIKIAN A, BEGIN L, FAIR W and BAZINET M: RAS P21 OVEREXPRESSION IS A LATE EVENT IN PROSTATE-CANCER. Int J Oncol 4: 627-631, 1994.
APA
HAMDY, S., APRIKIAN, A., BEGIN, L., FAIR, W., & BAZINET, M. (1994). RAS P21 OVEREXPRESSION IS A LATE EVENT IN PROSTATE-CANCER. International Journal of Oncology, 4, 627-631. https://doi.org/10.3892/ijo.4.3.627
MLA
HAMDY, S., APRIKIAN, A., BEGIN, L., FAIR, W., BAZINET, M."RAS P21 OVEREXPRESSION IS A LATE EVENT IN PROSTATE-CANCER". International Journal of Oncology 4.3 (1994): 627-631.
Chicago
HAMDY, S., APRIKIAN, A., BEGIN, L., FAIR, W., BAZINET, M."RAS P21 OVEREXPRESSION IS A LATE EVENT IN PROSTATE-CANCER". International Journal of Oncology 4, no. 3 (1994): 627-631. https://doi.org/10.3892/ijo.4.3.627
Copy and paste a formatted citation
x
Spandidos Publications style
HAMDY S, APRIKIAN A, BEGIN L, FAIR W and BAZINET M: RAS P21 OVEREXPRESSION IS A LATE EVENT IN PROSTATE-CANCER. Int J Oncol 4: 627-631, 1994.
APA
HAMDY, S., APRIKIAN, A., BEGIN, L., FAIR, W., & BAZINET, M. (1994). RAS P21 OVEREXPRESSION IS A LATE EVENT IN PROSTATE-CANCER. International Journal of Oncology, 4, 627-631. https://doi.org/10.3892/ijo.4.3.627
MLA
HAMDY, S., APRIKIAN, A., BEGIN, L., FAIR, W., BAZINET, M."RAS P21 OVEREXPRESSION IS A LATE EVENT IN PROSTATE-CANCER". International Journal of Oncology 4.3 (1994): 627-631.
Chicago
HAMDY, S., APRIKIAN, A., BEGIN, L., FAIR, W., BAZINET, M."RAS P21 OVEREXPRESSION IS A LATE EVENT IN PROSTATE-CANCER". International Journal of Oncology 4, no. 3 (1994): 627-631. https://doi.org/10.3892/ijo.4.3.627
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