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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 1994 Volume 4 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 1994 Volume 4 Issue 3

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Article

BCL-2 GENE PREVENTS INDUCTION OF APOPTOSIS IN L1210 MURINE LEUKEMIA-CELLS BY SN-38, A METABOLITE OF THE CAMPTOTHECIN DERIVATIVE CPT-11

  • Authors:
    • S KONDO
    • D YIN
    • T MORIMURA
    • J TAKEUCHI

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    Affiliations: Affliations not specified
  • Pages: 649-654
    |
    Published online on: March 1, 1994
       https://doi.org/10.3892/ijo.4.3.649
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Abstract

New camptothecin (CPT) derivatives have recently been synthesized following the finding that CPT has strong antitumor activity due to its inhibition of topoisomerase I through the formation of stable topoisomerase I-DNA cleavable complexes, but has not been clinically used due to its pronounced toxicity. 7-ethyl-10-hydroxy-CPT (SN-38), a metabolite of the CPT derivative 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxy-CPT(CPT-11), plays an essential role in mediating the antitumor effect of CPT-11. However, the reasons for the cytotoxicity of SN-38 remain unclear. In this study, we demonstrated using results of DNA fragmentation assay and cell cycle analysis that SN-38 and CPT both induce apoptosis in L1210 murine leukemia cells. We demonstrated in addition that enforced expression of the bcl-2 gene in L1210 cells by MPZenNeo (bcl-2) retroviral gene transfer increased resistance to the apoptosis induced by SN-38 and CPT. These findings suggest the possibility that the bcl-2 gene impedes the activity of a common pathway for apoptosis induced by SN-38 and CPT.

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Copy and paste a formatted citation
Spandidos Publications style
KONDO S, YIN D, MORIMURA T and TAKEUCHI J: BCL-2 GENE PREVENTS INDUCTION OF APOPTOSIS IN L1210 MURINE LEUKEMIA-CELLS BY SN-38, A METABOLITE OF THE CAMPTOTHECIN DERIVATIVE CPT-11. Int J Oncol 4: 649-654, 1994.
APA
KONDO, S., YIN, D., MORIMURA, T., & TAKEUCHI, J. (1994). BCL-2 GENE PREVENTS INDUCTION OF APOPTOSIS IN L1210 MURINE LEUKEMIA-CELLS BY SN-38, A METABOLITE OF THE CAMPTOTHECIN DERIVATIVE CPT-11. International Journal of Oncology, 4, 649-654. https://doi.org/10.3892/ijo.4.3.649
MLA
KONDO, S., YIN, D., MORIMURA, T., TAKEUCHI, J."BCL-2 GENE PREVENTS INDUCTION OF APOPTOSIS IN L1210 MURINE LEUKEMIA-CELLS BY SN-38, A METABOLITE OF THE CAMPTOTHECIN DERIVATIVE CPT-11". International Journal of Oncology 4.3 (1994): 649-654.
Chicago
KONDO, S., YIN, D., MORIMURA, T., TAKEUCHI, J."BCL-2 GENE PREVENTS INDUCTION OF APOPTOSIS IN L1210 MURINE LEUKEMIA-CELLS BY SN-38, A METABOLITE OF THE CAMPTOTHECIN DERIVATIVE CPT-11". International Journal of Oncology 4, no. 3 (1994): 649-654. https://doi.org/10.3892/ijo.4.3.649
Copy and paste a formatted citation
x
Spandidos Publications style
KONDO S, YIN D, MORIMURA T and TAKEUCHI J: BCL-2 GENE PREVENTS INDUCTION OF APOPTOSIS IN L1210 MURINE LEUKEMIA-CELLS BY SN-38, A METABOLITE OF THE CAMPTOTHECIN DERIVATIVE CPT-11. Int J Oncol 4: 649-654, 1994.
APA
KONDO, S., YIN, D., MORIMURA, T., & TAKEUCHI, J. (1994). BCL-2 GENE PREVENTS INDUCTION OF APOPTOSIS IN L1210 MURINE LEUKEMIA-CELLS BY SN-38, A METABOLITE OF THE CAMPTOTHECIN DERIVATIVE CPT-11. International Journal of Oncology, 4, 649-654. https://doi.org/10.3892/ijo.4.3.649
MLA
KONDO, S., YIN, D., MORIMURA, T., TAKEUCHI, J."BCL-2 GENE PREVENTS INDUCTION OF APOPTOSIS IN L1210 MURINE LEUKEMIA-CELLS BY SN-38, A METABOLITE OF THE CAMPTOTHECIN DERIVATIVE CPT-11". International Journal of Oncology 4.3 (1994): 649-654.
Chicago
KONDO, S., YIN, D., MORIMURA, T., TAKEUCHI, J."BCL-2 GENE PREVENTS INDUCTION OF APOPTOSIS IN L1210 MURINE LEUKEMIA-CELLS BY SN-38, A METABOLITE OF THE CAMPTOTHECIN DERIVATIVE CPT-11". International Journal of Oncology 4, no. 3 (1994): 649-654. https://doi.org/10.3892/ijo.4.3.649
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