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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 1994 Volume 4 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 1994 Volume 4 Issue 5

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Article

MODULATION OF RETINOIC ACID RECEPTOR-ALPHA, GROWTH-FACTORS AND PROTOONCOGENES IN RETINOIC ACID-INDUCED APOPTOSIS OF KI-1 LYMPHOMA CELL-LINE

  • Authors:
    • IJ SU
    • ZD LAY
    • AL CHENG
    • YC CHANG

  • View Affiliations / Copyright

    Affiliations: NATL TAIWAN UNIV,COLL MED,DEPT PATHOL,TAIPEI 10764,TAIWAN. NATL TAIWAN UNIV,COLL MED,DEPT INTERNAL MED,TAIPEI 10764,TAIWAN.
  • Pages: 1089-1095
    |
    Published online on: May 1, 1994
       https://doi.org/10.3892/ijo.4.5.1089
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Abstract

We have previously reported the successful salvage by retinoid acid (RA) of patients with refractory Ki-1 lymphoma. In this study, we have further investigated the effect of all-trans RA on a Ki-1 lymphoma cell line SR786. Similar to the clinical observation, SR786 cells were sensitive to RA treatment (ID50=0.6 mu m). RA-treated SR786 cells were transformed to a more differentiated morphology at 24 h, and subsequently died via apoptosis at 48-72 h. This process was associated with a decreased expression of the proliferation markers and c-myc proto-oncogene. The RA receptor alpha (RAR-alpha), however, showed an immediate enhanced expression at 1/2 h, and followed by an increase of transforming growth factor-beta 1 (TGF-beta 1) gene expression. The apoptosis and increased expression of TGF-beta 1 could be completely blocked;by the addition of cycloheximide given within 12 h of RA treatment. It appears that the RA-induced apoptosis of SR-786 is the result of an RA-induced upregulation of RAR-alpha and a subsequent activation of TGF-beta 1, which in turn leads to a cascade of the suppression of growth-related genes. Our observations strongly support the use of retinoids in Ki-1 lymphoma and invite further studies to test the potential of RA in other specific type T-cell lymphomas.

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Copy and paste a formatted citation
Spandidos Publications style
SU I, LAY Z, CHENG A and CHANG Y: MODULATION OF RETINOIC ACID RECEPTOR-ALPHA, GROWTH-FACTORS AND PROTOONCOGENES IN RETINOIC ACID-INDUCED APOPTOSIS OF KI-1 LYMPHOMA CELL-LINE. Int J Oncol 4: 1089-1095, 1994.
APA
SU, I., LAY, Z., CHENG, A., & CHANG, Y. (1994). MODULATION OF RETINOIC ACID RECEPTOR-ALPHA, GROWTH-FACTORS AND PROTOONCOGENES IN RETINOIC ACID-INDUCED APOPTOSIS OF KI-1 LYMPHOMA CELL-LINE. International Journal of Oncology, 4, 1089-1095. https://doi.org/10.3892/ijo.4.5.1089
MLA
SU, I., LAY, Z., CHENG, A., CHANG, Y."MODULATION OF RETINOIC ACID RECEPTOR-ALPHA, GROWTH-FACTORS AND PROTOONCOGENES IN RETINOIC ACID-INDUCED APOPTOSIS OF KI-1 LYMPHOMA CELL-LINE". International Journal of Oncology 4.5 (1994): 1089-1095.
Chicago
SU, I., LAY, Z., CHENG, A., CHANG, Y."MODULATION OF RETINOIC ACID RECEPTOR-ALPHA, GROWTH-FACTORS AND PROTOONCOGENES IN RETINOIC ACID-INDUCED APOPTOSIS OF KI-1 LYMPHOMA CELL-LINE". International Journal of Oncology 4, no. 5 (1994): 1089-1095. https://doi.org/10.3892/ijo.4.5.1089
Copy and paste a formatted citation
x
Spandidos Publications style
SU I, LAY Z, CHENG A and CHANG Y: MODULATION OF RETINOIC ACID RECEPTOR-ALPHA, GROWTH-FACTORS AND PROTOONCOGENES IN RETINOIC ACID-INDUCED APOPTOSIS OF KI-1 LYMPHOMA CELL-LINE. Int J Oncol 4: 1089-1095, 1994.
APA
SU, I., LAY, Z., CHENG, A., & CHANG, Y. (1994). MODULATION OF RETINOIC ACID RECEPTOR-ALPHA, GROWTH-FACTORS AND PROTOONCOGENES IN RETINOIC ACID-INDUCED APOPTOSIS OF KI-1 LYMPHOMA CELL-LINE. International Journal of Oncology, 4, 1089-1095. https://doi.org/10.3892/ijo.4.5.1089
MLA
SU, I., LAY, Z., CHENG, A., CHANG, Y."MODULATION OF RETINOIC ACID RECEPTOR-ALPHA, GROWTH-FACTORS AND PROTOONCOGENES IN RETINOIC ACID-INDUCED APOPTOSIS OF KI-1 LYMPHOMA CELL-LINE". International Journal of Oncology 4.5 (1994): 1089-1095.
Chicago
SU, I., LAY, Z., CHENG, A., CHANG, Y."MODULATION OF RETINOIC ACID RECEPTOR-ALPHA, GROWTH-FACTORS AND PROTOONCOGENES IN RETINOIC ACID-INDUCED APOPTOSIS OF KI-1 LYMPHOMA CELL-LINE". International Journal of Oncology 4, no. 5 (1994): 1089-1095. https://doi.org/10.3892/ijo.4.5.1089
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